Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Xue, Yu and a compound is mentioned, 123536-14-1, (R)-3-Aminoquinuclidine dihydrochloride, introducing its new discovery. Application In Synthesis of (R)-3-Aminoquinuclidine dihydrochloride
Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists
Human alpha7 nicotinic acetylcholine receptor (nAChR) is a promising therapeutic target for the treatment of schizophrenia accompanied with cognitive impairment. Herein, we report the synthesis and agonistic activities of a series of indolizine derivatives targeting to alpha7 nAChR. The results show that all synthesized compounds have affinity to alpha7 nAChR and some give strong agonistic activity, particularly most active agonists show higher potency than control EVP-6124. The docking and structure-activity relationship studies provide insights to develop more potent novel alpha7 nAChR agonists.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 123536-14-1
Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H159N | ChemSpider