Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 123536-14-1, C7H16Cl2N2. A document type is Article, introducing its new discovery., Safety of (R)-3-Aminoquinuclidine dihydrochloride
Dual organocatalysis: Asymmetric allylic-allylic alkylation of alpha,alpha-dicyanoalkenes and Morita-Baylis-Hillman carbonates
The unprecedented asymmetric allylic-allylic alkylation of alpha,alpha-dicyanoalkenes and Morita-Baylis-Hillman (MBH) carbonates were developed by catalyzing by a suitable chiral tertiary amine. The resulting multifunctional alkylation products could also serve as versatile intermediates for other synthetic transformations. The analogous catalysts show no catalytic activity in the model reaction due to steric activity. The alkylation reaction could be conducted at higher temperature in 1,2-dichloroethane (DCE) with little effect on the enantioselectivity. Excellent results are obtained by employing two equivalents of the MBH adduct and when 10% mol of (R)-BINOL is used. Mixtures of mono and double-allylic alkylation products are formed when symmetric alpha,alpha-dicyanoalkenes are applied. It is also found that the double-allylic alkylation adducts with four stereogenic centers could be isolated as single diasteromers with remarkable ee values.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 123536-14-1
Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H141N | ChemSpider