Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner.In an article, author is Nordvall, G, once mentioned the application of 5392-40-5, Name is 3,7-Dimethylocta-2,6-dienal, molecular formula is C10H16O, molecular weight is 152.2334, MDL number is MFCD00006997, category is quinuclidine. Now introduce a scientific discovery about this category, Application In Synthesis of 3,7-Dimethylocta-2,6-dienal.
3-(2-benzofuranyl)quinuclidin-2-ene derivatives: Novel muscarinic antagonists
A series of 26 derivatives of the novel muscarinic antagonist 3-(2-benzofuranyl) quinuclidin-2-ene (1) has been synthesized and evaluated for muscarinic and antimuscarinic properties. The affinity of the compounds was determined by competition experiments in homogenates of cerebral cortex, heart, parotid gland, and urinary bladder from guinea pigs using (-)-[H-3]-3-quinuclidinyl benzilate as the radioligand, and the antimuscarinic potency was determined in a functional assay on isolated guinea pig urinary bladder using carbachol as the agonist. The 5-fluorobenzofuranyl derivative was slightly more potent than 1. The 7-bromo-substituted 8 displayed a 14-fold tissue selectivity ratio for muscarinic receptors in the cortex versus the parotid gland. Comparative molecular field analysis and quantitative structure-activity relationship models were developed for this series of substituted benzofuranyl derivatives.
Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.Interested yet? Keep reading other articles of 5392-40-5, you can contact me at any time and look forward to more communication. Application In Synthesis of 3,7-Dimethylocta-2,6-dienal.
Reference:
Quinuclidine – Wikipedia,
,Quinuclidine | C7H13N | ChemSpider