Berne, Sabina’s team published research in Bioorganic & Medicinal Chemistry in 23 | CAS: 20029-52-1

Bioorganic & Medicinal Chemistry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Quality Control of 20029-52-1.

Berne, Sabina published the artcileBenzoic acid derivatives with improved antifungal activity: design, synthesis, structure-activity relationship (SAR) and CYP53 docking studies, Quality Control of 20029-52-1, the publication is Bioorganic & Medicinal Chemistry (2015), 23(15), 4264-4276, database is CAplus and MEDLINE.

Previously, the authors identified CYP53 as a fungal-specific target of natural phenolic antifungal compounds and discovered several inhibitors with antifungal properties. In this study, they performed similarity-based virtual screening and synthesis to obtain benzoic acid-derived compounds and assessed their antifungal activity against Cochliobolus lunatus, Aspergillus niger and Pleurotus ostreatus. In addition, the authors generated structural models of CYP53 enzyme and used them in docking trials with 40 selected compounds Finally, they explored CYP53-ligand interactions and identified structural elements conferring increased antifungal activity to facilitate the development of potential new antifungal agents that specifically target CYP53 enzymes of animal and plant pathogenic fungi.

Bioorganic & Medicinal Chemistry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Quality Control of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider