Li, Tianlei published the artcileMetallaphotoredox-catalyzed C-H activation: regio-selective annulation of allenes with benzamide, Synthetic Route of 20029-52-1, the publication is Organic Chemistry Frontiers (2021), 8(5), 928-935, database is CAplus.
An efficient annulation of benzamides I (R = 4-ClC6H4, 2-naphthyl, 2-thienyl, etc.) with allenes R2CCCH2 (R1 = C6H5, C(O)2CH3, C(O)2CH2C6H5, etc.; R2 = H, CH3) using cobalt and photoredox dual catalysis under an oxygen atm. has been described. This reaction provides a mild and environmentally friendly method for the construction of isoquinolinone scaffolds, e.g., II in good to excellent yields, demonstrating broad substrate scopes, high regioselectivity, and good functional group compatibility. Notably, the transformation features an alternative strategy for the regeneration of a cobalt catalyst with the aid of Eosin Y. Preliminary mechanistic studies reveal that a radical-mediated cascade annulation is involved in this reaction.
Organic Chemistry Frontiers published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Synthetic Route of 20029-52-1.
Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider