Day: November 21, 2022

Hu, Fengshuo published the artcileEpoxidized soybean oil modified using fatty acids as tougheners for thermosetting epoxy resins: Part 2-Effect of curing agent and epoxy molecular weight, Safety of 4,4-Diaminodicyclohexyl methane, the publication is Journal of Applied Polymer Science (2021), 138(24), 50579, database is CAplus.

A series of bio-rubber (BR) tougheners for thermosetting epoxy resins was prepared by grafting renewable fatty acids with different chain lengths onto epoxidized soybean oil at varying molar ratios. BR-toughened samples were prepared by blending BRs with diglycidyl ether of bisphenol A resins, Epon 828 and Epon 1001F, at different weight fractions and stoichiometrically cured using an amine curing agent, 4, 4′-methylene biscyclohexanamine (PACM). Fracture toughness properties of the unmodified and BR toughened polymer samples-including critical strain energy release rate (G_Ic), and critical stress intensity factor (K_Ic)-were measured to investigate the toughening effect of prepared BRs. It was found that the degree of phase separation and toughening were more controllable relative to similar polymers cured using the aromatic curing agent Epikure W, and the use of higher mol. epoxy resins produces a synergistic effect increasing the toughness much more than similar polymers made with lower mol. weight epoxy resins. Average BR domain sizes ranging from 200 to 900 nm were observed, and formulations with G_Ic, values K_Ic as high as 1.0 kJ/m² and 1.4 MPa m^1/2 were attained resp. for epoxy systems with T_g greater than 130°C.

Journal of Applied Polymer Science published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Safety of 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Rumyantseva, Yu. B. published the artcileIntensification of oxidation of cyclohexyltoluene to hydroperoxide, Computed Properties of 20029-52-1, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (2011), 54(10), 102-104, database is CAplus.

Liquid phase oxidation of cyclohexyltoluene to hydroperoxide was studied in the presence of initiator – isopropylbenzene hydroperoxide and nitrogen-containing catalysts. The oxidation rate of cyclohexyltoluene increases 2.5-3 times at the presence of N-hydroxyphthalimide at 110-140°. The hydrocarbon conversion is up to 28-30% and the selectivity of cyclohexyltoluene hydroperoxide I formation is 93-95%.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Computed Properties of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Sekhar, B. V. V. N. Chandra published the artcileSynthesis of Montelukast sodium via an ester intermediate; synthesis and characterization of impurities, HPLC of Formula: 162515-68-6, the publication is International Journal of Pharma and Bio Sciences (2011), 2(3), 399-407, database is CAplus.

Novel synthetic approaches for the synthesis of a leukotriene receptor antagonist, Montelukast sodium [i.e., 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt] were designed. Reduction of the starting material [methyl (E)-2-[3-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoate] provided an alc. compound and the formation of montelukast dicyclohexylamine was accomplished by subsequent introduction of (mercaptomethyl)cyclopropaneacetic acid. The current study also deals with the synthesis and characterization of reaction products which are classified as impurities of Montelukast sodium. Impurities and byproducts reported here included a sulfine (sulfoxide), (S)-montelukast (acid), etc.

International Journal of Pharma and Bio Sciences published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C10H16Br3N, HPLC of Formula: 162515-68-6.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Fredenhagen, Andreas published the artcileEvaluation of the optimization space for atmospheric pressure photoionization (APPI) in comparison with APCI, COA of Formula: C13H16O2, the publication is Journal of Mass Spectrometry (2014), 49(8), 727-736, database is CAplus and MEDLINE.

The usefulness of atm. pressure photoionization (APPI) is difficult to evaluate for unknowns due to the fragmented literature. Specifically, the variation of dopants with a wide set of compounds or the use of APPI in the neg. mode have rarely been explored. Thirty compounds were selected that were not suitable for ESI with a wide variety of functional groups and investigated with atm. pressure chem. ionization (APCI) and APPI in the pos. and neg. ion modes. The influence of the mobile phase (eluents containing acetonitrile or methanol) and – for APPI – four different dopants (acetone, chlorobenzene, toluene, and toluene/anisole) were explored. Stepwise variation of the organic mobile phase allowed to elucidate the ionization mechanism. Atm. pressure photoionization was especially useful for compounds, where the M^•+ and not the [M + H]⁺ was formed. The dopants chlorobenzene and anisole promoted the formation of mol. ions M^•+ for about half of the compounds, and its formation was also pos. influenced by the use of mobile phases containing methanol. In the neg. ion mode, APPI offered no advantage toward APCI. Best results were generally achieved with the dopant chlorobenzene, establishing that this dopant is suitable for a wide set of compounds For one quarter of the compounds, significantly better results were achieved with mobile phases containing methanol for both APPI and APCI than those with acetonitrile, but only in the pos. mode. With either of the methods – APPI or APCI – about 10% of the compounds were not detected. Strategies to get results quickly with difficult unknowns will be discussed.

Journal of Mass Spectrometry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, COA of Formula: C13H16O2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Reichmuth, Andreas M. published the artcileInvestigating Complex Samples with Molograms of Low-Affinity Binders, Recommanded Product: Dbco-acid, the publication is ACS Sensors (2021), 6(3), 1067-1076, database is CAplus and MEDLINE.

In vitro diagnostics relies on the quantification of minute amounts of a specific biomol., called biomarker, from a biol. sample. The majority of clin. relevant biomarkers for conditions beyond infectious diseases are detected by means of binding assays, where target biomarkers bind to a solid phase and are detected by biochem. or phys. means. Nonspecifically bound biomols., the main source of variation in such assays, need to be washed away in a laborious process, restricting the development of widespread point-of-care diagnostics. Here, we show that a diffractometric assay provides a new, label-free possibility to investigate complex samples, such as blood plasma. A coherently arranged sub-micron pattern, i.e., a peptide mologram, is created to demonstrate the insensitivity of this diffractometric assay to the unwanted masking effect of nonspecific interactions. In addition, using an array of low-affinity binders, we also demonstrate the feasibility of mol. profiling of blood plasma in real time and show that individual patients can be differentiated based on the binding kinetics of circulating proteins.

ACS Sensors published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Recommanded Product: Dbco-acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Haque, Bazle Z. published the artcileDepth of penetration experiments of S-2 glass/epoxy composites: A new experimental methodology in determining the rate dependent dynamic crush strength of composites, Recommanded Product: 4,4-Diaminodicyclohexyl methane, the publication is Composites, Part B: Engineering (2022), 109917, database is CAplus.

Depth of penetration (DoP) experiments have been conducted on thick section S-2 glass/epoxy laminates impacted by 64 grain steel projectiles over an impact velocity range of 400 m/s to 1400 m/s. Under high velocity impact, the composite under the projectile is highly compressed and crushes into powder. A theor. model is developed to reduce DoP data that relates the plastic/granular wave velocity, plastic/granular strain and strain rate during penetration to the strain rate dependent dynamic punch crush strength and plastic/granular erosion strain of composite for the first time in the literature. Punch crush strength is an important material property used in rate dependent progressive composite damage models. DoP experiments on thick section composites are presented to study the effects of fiber volume fraction, fabric architecture, and inelastic matrix behavior on depth of penetration and damage modes. The new data reduction methodol. is used to calculate the rate dependent punch crush strength of glass/epoxy laminates.

Composites, Part B: Engineering published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Recommanded Product: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

King, Ryan P. published the artcileA Ligand Exchange Process for the Diversification of Palladium Oxidative Addition Complexes, Safety of 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, the publication is Organic Letters (2021), 23(15), 6030-6034, database is CAplus and MEDLINE.

Palladium oxidative addition complexes (OACs) have recently emerged as useful tools to enable challenging bond connections. However, each OAC can only be formed with one dative ligand at a time. As no one ligand is optimal for every cross-coupling reaction, we herein disclose a ligand exchange protocol for the preparation of a series of OACs bearing a variety of ancillary ligands from one common complex. These complexes were further applied to cross-coupling transformations.

Organic Letters published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Safety of 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

King, Ryan P. published the artcileA Neophyl Palladacycle as an Air- and Thermally Stable Precursor to Oxidative Addition Complexes, COA of Formula: C28H41N2P, the publication is Organic Letters (2021), 23(20), 7927-7932, database is CAplus and MEDLINE.

The use of isolated Pd Oxidative Addition Complexes (OACs) has had a significant impact on Pd-catalyzed and Pd-mediated cross-coupling reactions. Despite their importance, widespread utility of OACs was limited by the instability of their precursor complexes. Herein, the authors report the use of Campora’s palladacycle as a new, more stable precursor to Pd OACs. Using this palladacycle, biarylphosphine ligated OACs, including those with pharmaceutical-derived aryl halides and relevance to bioconjugation, were prepared

Organic Letters published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, COA of Formula: C28H41N2P.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Wortmann, Martin published the artcileEffect of Isocyanate Absorption on the Mechanical Properties of Silicone Elastomers in Polyurethane Vacuum Casting, Recommanded Product: 4,4-Diaminodicyclohexyl methane, the publication is ACS Omega (2021), 6(7), 4687-4695, database is CAplus and MEDLINE.

Polyurethane vacuum casting with silicone molds is a widely used industrial process for the production of prototypes and small batches. Since the silicone casting molds absorb the isocyanate component of the curing PUR casting resin at the cavity surface, the service life of the molds is typically restricted to very few casting cycles. The successive deterioration of the material properties results from the polymerization of the absorbed isocyanate with moisture to polyurea derivatives within the silicone matrix. In this study, we show for the first time the influence of isocyanate absorption on the mech. properties of silicone elastomers as well as quant. differences between com. materials. The changes in mech. properties were quantified in terms of Shore A hardness, Young’s modulus, tensile strength, elongation at break, and complex shear modulus. It was found that the influence of the isocyanate type on the relative property changes of the silicone was significantly greater than that of the silicone used. The results show that, regardless of its hardness, the silicone absorbs considerably less methylene di-Ph diisocyanate (MDI) than hydrogenated MDI, although the latter causes less deterioration of the mech. properties and achieves a longer mold service life.

ACS Omega published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C65H82N2O18S2, Recommanded Product: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Berne, Sabina published the artcileBenzoic acid derivatives with improved antifungal activity: design, synthesis, structure-activity relationship (SAR) and CYP53 docking studies, Quality Control of 20029-52-1, the publication is Bioorganic & Medicinal Chemistry (2015), 23(15), 4264-4276, database is CAplus and MEDLINE.

Previously, the authors identified CYP53 as a fungal-specific target of natural phenolic antifungal compounds and discovered several inhibitors with antifungal properties. In this study, they performed similarity-based virtual screening and synthesis to obtain benzoic acid-derived compounds and assessed their antifungal activity against Cochliobolus lunatus, Aspergillus niger and Pleurotus ostreatus. In addition, the authors generated structural models of CYP53 enzyme and used them in docking trials with 40 selected compounds Finally, they explored CYP53-ligand interactions and identified structural elements conferring increased antifungal activity to facilitate the development of potential new antifungal agents that specifically target CYP53 enzymes of animal and plant pathogenic fungi.

Bioorganic & Medicinal Chemistry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Quality Control of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider