Reichmuth, Andreas M. published the artcileInvestigating Complex Samples with Molograms of Low-Affinity Binders, Recommanded Product: Dbco-acid, the publication is ACS Sensors (2021), 6(3), 1067-1076, database is CAplus and MEDLINE.
In vitro diagnostics relies on the quantification of minute amounts of a specific biomol., called biomarker, from a biol. sample. The majority of clin. relevant biomarkers for conditions beyond infectious diseases are detected by means of binding assays, where target biomarkers bind to a solid phase and are detected by biochem. or phys. means. Nonspecifically bound biomols., the main source of variation in such assays, need to be washed away in a laborious process, restricting the development of widespread point-of-care diagnostics. Here, we show that a diffractometric assay provides a new, label-free possibility to investigate complex samples, such as blood plasma. A coherently arranged sub-micron pattern, i.e., a peptide mologram, is created to demonstrate the insensitivity of this diffractometric assay to the unwanted masking effect of nonspecific interactions. In addition, using an array of low-affinity binders, we also demonstrate the feasibility of mol. profiling of blood plasma in real time and show that individual patients can be differentiated based on the binding kinetics of circulating proteins.
ACS Sensors published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Recommanded Product: Dbco-acid.
Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider