Month: November 2022

Perryman, S. Connor published the artcileIncorporating crosslinks in fused filament fabrication: Molecular insight into post deposition reactions, Formula: C13H26N2, the publication is Additive Manufacturing (2021), 101746, database is CAplus.

3D printed objects suffer from intrinsic mech. weakness due to low interlayer adhesion and defects that result in anisotropy in their mech. properties. In this report, we examine the ability of a protocol to incorporate covalent bonds between layers to strengthen interlayer adhesion by depositing multi-amines between layers during the fused filament fabrication printing process. The multi-amines may then react with oxygenated functional groups on the deposited filament to form covalent crosslinks between layers. Determination of the interfacial fracture energy and IR spectroscopy studies indicate the successful formation of covalent bonds and strengthening of the interlayer interface with a variety of multi-amines. More importantly, IR results also elucidate the relative rate of reaction of the amines with oxygenated functional groups found on the oxidized filament. These results show that the crosslinking reactions primarily occur shortly after deposition of the filament, i.e. at elevated temperatures The data also show that the reactivity of the amines is not the prevailing factor in determining interfacial strength, as the aromaticity of the crosslinker plays a key role in creating a stronger interface. These results therefore provide important foundational understanding that can be used to apply this protocol to a variety of extrusion based additive processes and materials.

Additive Manufacturing published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Formula: C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Sanchez, Laura M. published the artcileVersatile Method for the Detection of Covalently Bound Substrates on Solid Supports by DART Mass Spectrometry, Application In Synthesis of 20029-52-1, the publication is Organic Letters (2011), 13(15), 3770-3773, database is CAplus and MEDLINE.

Anal. of substrates directly on solid phase resins without the need for sep. cleavage conditions remains an outstanding challenge in the field of solid phase synthesis. The authors now present the 1st example of simultaneous cleavage and mass spectrometric anal. of peptides from solid supports using direct anal. in real time (DART) mass spectrometry. This method is compatible with a diverse array of solid phase resins and is suitable for anal. of both peptides and organic substrates.

Organic Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Application In Synthesis of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Chen, Yue published the artcileA Ligand System for the Flexible Functionalization of Quantum Dots via Click Chemistry, Recommanded Product: Dbco-acid, the publication is Angewandte Chemie, International Edition (2018), 57(17), 4652-4656, database is CAplus and MEDLINE.

We present a novel ligand, 5-norbornene-2-nonanoic acid, which can be directly added during established quantum dot (QD) syntheses in organic solvents to generate “clickable” QDs at a few hundred nmol scale. This ligand has a carboxyl group at one terminus to bind to the surface of QDs and a norbornene group at the opposite end that enables straightforward phase transfer of QDs into aqueous solutions via efficient norbornene/tetrazine click chem. Our ligand system removes the traditional ligand-exchange step and can produce water-soluble QDs with a high quantum yield and a small hydrodynamic diameter of approx. 12 nm at an order of magnitude higher scale than previous methods. We demonstrate the effectiveness of our approach by incubating azido-functionalized CdSe/CdS QDs with 4T1 cancer cells that are metabolically labeled with a dibenzocyclooctyne-bearing unnatural sugar. The QDs exhibit high targeting efficiency and minimal nonspecific binding.

Angewandte Chemie, International Edition published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Recommanded Product: Dbco-acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Moss, Neil published the artcileA new class of 5-HT_2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties, Application In Synthesis of 20029-52-1, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(8), 2206-2210, database is CAplus and MEDLINE.

The authors have been exploring the potential of 5-HT_2B antagonists as a therapy for chronic heart failure. To assess the potential of this therapeutic approach, they sought compounds possessing the following attributes: (a) potent and selective antagonism of the 5-HT_2B receptor, (b) low impact of serum proteins on potency, and (c) desirable pharmacokinetic properties. This Letter describes their investigation of a biphenyl benzimidazole class of compounds that resulted in 5-HT_2B antagonists possessing the above attributes. Improving potency in a human serum albumin shift assay proved to be the most significant SAR discovery.

Bioorganic & Medicinal Chemistry Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Application In Synthesis of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Song, Sam Cha published the artcileSynthesis and properties of waterborne polyurethane dispersions for surface coatings on poly(vinyl chloride), Formula: C13H26N2, the publication is Molecular Crystals and Liquid Crystals (2020), 706(1), 101-107, database is CAplus.

Recently, conventional solvent-typed polyurethanes are subject to many regulations due to emission of organic volatile compounds (VOCs) and researches have been focused on eco-friendly waterborne polyurethane dispersions (WPUDs) as an alternative of conventional solvent-typed ones causing poor working environment. PVC is widely used because of low price and good heat and fire resistance. To develop eco-friendly coatings on poly(vinyl chloride) (PVC), various WPUDs were synthesized by combination of polyol such as polyester, polycaprolactone, polyether or polycarbonate, hydrophilic compounds (dimethylol butanoic acid, DMBA), and reactive silicone. The structure and properties of synthesized WPUDs were characterized by FT-IR, particle size, contact angle, surface energy, tensile strength, elongation, and adhesion strength. Also, their particle sizes decreased while tensile strengths increased with increasing DMBA content. Surface energy and contact angle of WPUDs were strongly affected by the content of hydrophobic reactive silicone. The optimum properties of WPUDs were obtained by controlling their compositions, polyol, hydrophilic compound, and reactive silicone.

Molecular Crystals and Liquid Crystals published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C6H13BO3, Formula: C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Chen, Fengbiao published the artcileThe effect of latent plasticity on the shape recovery of a shape memory vitrimer, Name: 4,4-Diaminodicyclohexyl methane, the publication is European Polymer Journal (2021), 110304, database is CAplus.

The utility of covalent crosslinkers as permanent netpoints has enabled robust shape memory behavior in shape memory thermosets (SMTs). Having this permanent crosslinked structure, alternatively, challenges the reprogramming of permanent shapes. The introduction of vitrimeric type dynamic chem. into SMTs allows for reconfiguration of crosslinked network and thus reprogramming of permanent shapes. However, adding this adaptability/plasticity to the network could potentially affect the shape memory behavior, especially when the shape programming is conducted at a temperature that activates the network plasticity as well. Herein, to address the potential influence of network plasticity, we studied the shape memory behavior of a shape memory vitrimer (SMV) that possesses a low network activation energy (Ea) of 33 kJ/mol, which indicates a relatively high plasticity index during shape programming. As we found, there is a dependence of shape recovery on the shape-programming time: a longer programming time leads to a poorer shape recovery. This neg. correlation results from the dissipation of stored elastic energy at local strained regions associated with shape programming. We further related the loss of elastic energy to the stress-relaxation that results from chain exchanges. Accordingly, the dependence can be analyzed with an analog of stress-relaxation model.

European Polymer Journal published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Name: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Liu, Zheng-Fei published the artcileUltralong lifetime room temperature phosphorescence and dual-band waveguide behavior of phosphoramidic acid oligomers, Computed Properties of 1761-71-3, the publication is Journal of Materials Chemistry C: Materials for Optical and Electronic Devices (2020), 8(22), 7330-7335, database is CAplus.

Phosphoramidic acid is introduced into an oligomer matrix to construct a nonconjugated luminescence system with ultralong phosphorescence lifetimes up to 376.5 and 776.9 ms and high phosphorescence quantum yield (4.6-10.5%). At the same time, the new system also displays good thermo-processing properties, vitreous solid and optical waveguide behavior.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Computed Properties of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Li, Zhen published the artcileDiscovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (S1P₁) Receptor Agonists with Exceptional Selectivity against S1P₂ and S1P₃, Related Products of quinuclidine, the publication is Journal of Medicinal Chemistry (2005), 48(20), 6169-6173, database is CAplus and MEDLINE.

A class of 3,5-diphenyl-1,2,4-oxadiazole based compounds have been identified as potent sphingosine-1-phosphate-1 (S1P₁) receptor agonists with minimal affinity for the S1P₂ and S1P₃ receptor subtypes. Analog 26 (S1P₁ IC₅₀ = 0.6 nM) has an excellent pharmacokinetics profile in the rat and dog and is efficacious in a rat skin transplant model, indicating that S1P₃ receptor agonism is not a component of immunosuppressive efficacy.

Journal of Medicinal Chemistry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Yi, Pengcheng published the artcileSelf-Healable, Strong, and Tough Polyurethane Elastomer Enabled by Carbamate-Containing Chain Extenders Derived from Ethyl Carbonate, HPLC of Formula: 1761-71-3, the publication is Polymers (Basel, Switzerland) (2022), 14(9), 1673, database is CAplus and MEDLINE.

Com. diol chain extenders generally could only form two urethane bonds, while abundant hydrogen bonds were required to construct self-healing thermoplastic polyurethane elastomers (TPU). Herein, two diol chain extenders bis(2-hydroxyethyl) (1,3-pheny-lene-bis-(methylene)) dicarbamate (BDM) and bis(2-hydroxyethyl) (methylenebis(cyclohexane-4,1-diy-l)) dicarbamate (BDH), containing two carbamate groups were successfully synthesized through the ring-opening reaction of ethylene carbonate (EC) with 1,3-benzenedimetha-namine (MX-DA) and 4, 4′-diaminodicyclohexylmethane (HMDA). The two chain extenders were applied to successfully achieve both high strength and high self-healing ability. The BDM-1.7 and BDH-1.7 elastomers had high comprehensive self-healing efficiency (100%, 95%) after heated treatment at 60 °C, and exhibited exceptional comprehensive mech. performances in tensile strength (20.6 ± 1.3 MPa, 37.1 ± 1.7 MPa), toughness (83.5 ± 2.0 MJ/m³, 118.8 ± 5.1 MJ/m³), puncture resistance (196.0 mJ, 626.0 mJ), and adhesion (4.6 MPa, 4.8 MPa). The peculiar mech. and self-healing properties of TPUs originated from the coexisting short and long hard segments, strain-induced crystallization (SIC). The two elastomers with excellent properties could be applied to engineering-grade fields such as com. sealants, adhesives, and so on.

Polymers (Basel, Switzerland) published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C3H7NO2, HPLC of Formula: 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Liu, Yingchun published the artcileUltrahigh thermal conductivity of epoxy composites based on curling bioinspired functionalized graphite films for thermal management application, Formula: C13H26N2, the publication is Composites, Part A: Applied Science and Manufacturing (2021), 106413, database is CAplus.

Unsatisfactory thermal conductive network (TCN) and poor heat conduction interface have limited thermal conductivity (TC) enhancement in the polymeric composites. In this study, inspired by mussels and a Chinese delicacy called the Hanamaki, a facile and environmental strategy is developed to prepare hierarchically ordered graphite film strips@polydopamine/epoxy (GFs@PDA/EP) composites. Organized TCNs and an optimized interface were constructed and thus an ultrahigh TC of GFs/EP (899.44 ± 18.51 W m^-1 K^-1) in perpendicular direction was obtained. Structural anal. and heat-transfer passages model suggests that superior TCNs were constructed and the designed structure is conducive for heat conduction in the perpendicular direction. Moreover, the interfacial bonding of GFs@PDA with EP matrix contributes to the remarkable enhancement of TC with increasing of PDA coverage. A decrease of ∼43°C in the thermal management experiment of LED chips indicated that it most likely becomes a good candidate in electronic device-cooling application.

Composites, Part A: Applied Science and Manufacturing published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Formula: C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider