A systematic study on the use of different organocatalytic activation modes for asymmetric conjugated addition reactions of isoindolinones was written by Scorzelli, Francesco;Di Mola, Antonia;De Piano, Francesco;Tedesco, Consiglia;Palombi, Laura;Filosa, Rosanna;Waser, Mario;Massa, Antonio. And the article was included in Tetrahedron in 2017.Formula: C26H29ClN2O This article mentions the following:
The authors describe a series of new asym. Michael reactions of 3-carboxylate-substituted isoindolinones used as nucleophiles in the synthesis of valuable chiral tetrasubstituted derivatives It has been shown that the reactivity and enantioselectivity strongly depend on the substitution pattern of the isoindolinone, requiring either cinchona-alkaloid based phase transfer catalysts or bifunctional tertiary amines organocatalysts. Moreover, prolinol-TMS ether-based secondary amine catalysts permitted the development of Michael/cyclization tandem reaction with cinnamaldehyde for the synthesis of aza-polycyclic derivatives In the experiment, the researchers used many compounds, for example, (1S,2R,4S,5R)-1-Benzyl-2-(hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium chloride (cas: 69221-14-3Formula: C26H29ClN2O).
(1S,2R,4S,5R)-1-Benzyl-2-(hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium chloride (cas: 69221-14-3) belongs to quinuclidine derivatives. Quinuclidine acts as a catalyst, a chemical building block and is used in organic synthesis. It is employed to prepare quinine and alkaloids. Quinuclidine derivatives can also be formed conveniently by introducing substituents into the quinuclidine ring, but the scope of this method is rather limited by the available source of starting materials.Formula: C26H29ClN2O
Referemce:
Quinuclidine – Wikipedia,
Quinuclidine | C7H13N | ChemSpider