Halama, Ales published the artcileImproved Process for the Preparation of Montelukast: Development of an Efficient Synthesis, Identification of Critical Impurities and Degradants, Safety of 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, the publication is Organic Process Research & Development (2010), 14(2), 425-431, database is CAplus.
An improved and scalable process for the production of montelukast (Singulair, drug for asthma) based on an advantageous method of carrying out the key substitution reaction was developed. The present procedure is distinguished from the previous solutions in the use of linear or cyclic polyethers, which ensures higher selectivity of the key step. The improved process for the preparation of montelukast is able to minimize impurities and allows effective production of montelukast and its scale-up.
Organic Process Research & Development published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H10O2S, Safety of 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid.
Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider