Category: 123536-14-1

Application of 123536-14-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 123536-14-1, Name is (R)-3-Aminoquinuclidine dihydrochloride, molecular formula is C7H16Cl2N2. In a Patent£¬once mentioned of 123536-14-1

METHODS AND COMPOSITIONS COMPRISING DIAMINES AS NEW ANTI-TUBERCULAR THERAPEUTICS

Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising novel diamine compositions for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H161N | ChemSpider

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. HPLC of Formula: C7H16Cl2N2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 123536-14-1, name is (R)-3-Aminoquinuclidine dihydrochloride. In an article£¬Which mentioned a new discovery about 123536-14-1

Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists

The invention provides compounds of formula (I) wherein n, A, R1, R2 and R3 are as defined in the description, and the preparation thereof. The compounds of formula (I) are useful as pharmaceuticals.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H111N | ChemSpider

Reference of 123536-14-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 123536-14-1, Name is (R)-3-Aminoquinuclidine dihydrochloride, molecular formula is C7H16Cl2N2. In a Patent£¬once mentioned of 123536-14-1

CRYSTALLINE FUMARATE SALTS OF 1-AZABICYCLO[2.2.2]OCT SUBSTITUTED FURO[2,3-C]PYRIDINYL CARBOXAMIDE AND COMPOSITIONS AND PREPARATIONS THEREOF

The invention provides fumarate salts of N-[1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, compositions, racemic mixtures, or pure enantiomers thereof, and preparation thereof. The fumarate salts are useful to treat diseases or conditions in which alpha7 nAChR is known to be involved. Formula (I).

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Quinuclidine – Wikipedia,
Quinuclidine | C7H113N | ChemSpider

Reference of 123536-14-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 123536-14-1, Name is (R)-3-Aminoquinuclidine dihydrochloride, molecular formula is C7H16Cl2N2. In a Patent£¬once mentioned of 123536-14-1

NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

Compounds of formula (I), wherein D, Ar1, E and Ar2 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H105N | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, SDS of cas: 123536-14-1, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 123536-14-1, Name is (R)-3-Aminoquinuclidine dihydrochloride, molecular formula is C7H16Cl2N2

5-SUBSTITUTED IMIDAZOLES

Compounds of formula I: wherein A and R1 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.

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Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H102N | ChemSpider

Application of 123536-14-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 123536-14-1, Name is (R)-3-Aminoquinuclidine dihydrochloride, molecular formula is C7H16Cl2N2. In a Patent£¬once mentioned of 123536-14-1

Azabicyclic compounds for the treatment of disease

The invention provides compounds of Formula I: 1wherein Azabicyclo is 2W is a six-membered heterocyclic ring system having 1-2 nitrogen atoms or a 10-membered bicyclic-six-six-fused-ring system having up to two nitrogen atoms within either or both rings, provided that no nitrogen is at a bridge of the bicyclic-six-six-fused-ring system, and further having 1-2 substitutents independently selected from R3. These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to treat diseases or conditions in which alpha7 is known to be involved.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H104N | ChemSpider

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Dual organocatalysis: Asymmetric allylic-allylic alkylation of alpha,alpha-dicyanoalkenes and Morita-Baylis-Hillman carbonates

The unprecedented asymmetric allylic-allylic alkylation of alpha,alpha-dicyanoalkenes and Morita-Baylis-Hillman (MBH) carbonates were developed by catalyzing by a suitable chiral tertiary amine. The resulting multifunctional alkylation products could also serve as versatile intermediates for other synthetic transformations. The analogous catalysts show no catalytic activity in the model reaction due to steric activity. The alkylation reaction could be conducted at higher temperature in 1,2-dichloroethane (DCE) with little effect on the enantioselectivity. Excellent results are obtained by employing two equivalents of the MBH adduct and when 10% mol of (R)-BINOL is used. Mixtures of mono and double-allylic alkylation products are formed when symmetric alpha,alpha-dicyanoalkenes are applied. It is also found that the double-allylic alkylation adducts with four stereogenic centers could be isolated as single diasteromers with remarkable ee values.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H141N | ChemSpider

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Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds

The novel quinuclidine anti-1,2,3-triazole derivatives T1-T6 were designed based on the structure of QND8. The binding studies revealed that the stereochemistry at the C3 position of the quinuclidine scaffold plays an important role in the nAChR subtype selectivity. Whereas the (R)-enantiomers are selective to alpha7 over alpha4beta2 (by factors of 44-225) and to a smaller degree over alpha3beta4 (3-33), their (S)-counterparts prefer alpha3beta4 over alpha4beta2 (62-237) as well as over alpha7 (5-294). The (R)-derivatives were highly selective to alpha7 over alpha3beta4 subtypes compared to (RS)- and (R)-QND8. The (S)-enantiomers are 5-10 times more selective to alpha4beta2 than their (R) forms. The overall strongest affinity is observed for the (S)-enantiomer binding to alpha3beta4 (Ki, 2.25-19.5 nM) followed by their (R)-counterpart binding to alpha7 (Ki, 22.5-117 nM), with a significantly weaker (S)-enantiomer binding to alpha4beta2 (Ki, 414-1980 nM) still above the very weak respective (R)-analogue affinity (Ki, 5059-10436 nM).

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Quinuclidine – Wikipedia,
Quinuclidine | C7H154N | ChemSpider

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Pharmacological profile of zacopride and new quaternarized fluorobenzamide analogues on mammalian alpha7 nicotinic acetylcholine receptor

Abstract From quaternarization of quinuclidine enantiomers of 2-fluoro benzamide LMA10203 in dichloromethane, the corresponding N-chloromethyl derivatives LMA10227 and LMA10228 were obtained. Here, we compared the agonist action of known zacopride and its 2-fluoro benzamide analogues, LMA10203, LMA10227 and LMA10228 against mammalian homomeric alpha7 nicotinic acetylcholine receptor expressed in Xenopus oocytes. We found that LMA10203 was a partial agonist of alpha7 receptor with a pEC50 value of 4.25 ¡À 0.06 muM whereas LMA10227 and LMA10228 were poorly active on alpha7 homomeric nicotinic receptor. LMA10227 and LMA10228 were identified as antagonists of acetylcholine-induced currents with IC50 values of 28.4 muM and 39.3 muM whereas LMA10203 and zacopride possessed IC50 values of 8.07 muM and 7.04 muM, respectively. Moreover, despite their IC50 values, LMA10227 was the most potent inhibitor of nicotine-induced current amplitudes (65.7 ¡À 2.1% inhibition). LMA10203 and LMA10228 had the same inhibitory effects (26.5 ¡À 7.5% and 33.2 ¡À 4.1%, respectively), whereas zacopride had no significant inhibitory effect (4.37 ¡À 4%) on nicotine-induced responses. Our results revealed different pharmacological properties between the four compounds on acetylcholine and nicotine currents. The mode of action of benzamide compounds may need to be reinterpreted with respect to the potential role of alpha7 receptor.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H137N | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: (R)-3-Aminoquinuclidine dihydrochloride, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 123536-14-1, Name is (R)-3-Aminoquinuclidine dihydrochloride, molecular formula is C7H16Cl2N2

1,4-DISUBSTITUTED 1,2,3-TRIAZOLES, METHODS FOR PREPARING SAME, AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF

A compound having the following general formula (I): wherein: X is a nitrogen atom and Y is a carbon atom; or X is a carbon atom and Y is a nitrogen atom; the Ar group is an aryl or heteroaryl group; and the RN and RN? groups, together with the carbon atoms to which they are bound, form a monocyclic or bicyclic azacycloalkane group. The pharmaceutically acceptable salts thereof, the hydrates or polymorphic crystalline structures thereof, and to the racemates, diastereoisomers, or enantiomers thereof are also described.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H127N | ChemSpider