Category: 123536-14-1

Electric Literature of 123536-14-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.123536-14-1, Name is (R)-3-Aminoquinuclidine dihydrochloride, molecular formula is C7H16Cl2N2. In a Patent£¬once mentioned of 123536-14-1

ALKALOID ESTER AND CARBAMATE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF

Compounds according to formula (I) are effective for the treatment of broncho-obstructive and inflammatory diseases.

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Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H92N | ChemSpider

Application of 123536-14-1, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 123536-14-1, (R)-3-Aminoquinuclidine dihydrochloride, introducing its new discovery.

Preparation of S-(-)- and R-(+)-N-(quinuclidinyl-3)-amide

Optical active forms of the carboxylic acid amines of 3-aminoquinuclidine of formula (I), and the preparation thereof. These can be hydrolysed to the optical active forms of 3-aminoquinuclidine.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H112N | ChemSpider

Application of 123536-14-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 123536-14-1, Name is (R)-3-Aminoquinuclidine dihydrochloride, molecular formula is C7H16Cl2N2. In a Patent£¬once mentioned of 123536-14-1

2-indolizine Carbamoyl amine compound and its preparation and use (by machine translation)

The invention discloses a novel 2-indolizine formylamine derivative. The general formula of the novel 2-indolizine formylamine derivative is as shown in a formula (I), wherein the definition of R is specified in the specification. In addition, the invention also discloses a preparation method and a medicine composition of the compound. The 2-indolizine formylamine derivative disclosed by the invention has an acetylcholine alpha 7 receptor exciting effect. The formula (I) is as shown in the specification.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H134N | ChemSpider

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Quality Control of (R)-3-Aminoquinuclidine dihydrochloride. Introducing a new discovery about Quality Control of (R)-3-Aminoquinuclidine dihydrochloride, Name is (R)-3-Aminoquinuclidine dihydrochloride

Synthesis of quinazoline-2,4-dione and naphthalimide derivatives as new 5-HT3 receptor antagonists

New potent 5-HT3 receptor antagonists have been designed from the naphthalimide moiety and a quinuclidine heterocycle and the structure-activity relationships are discussed here on the basis of the nature of the substituent on the aromatic system. The biological activity of the compounds was evaluated in binding assays with [3H]BRL-43694 and by inhibition of the Bezold-Jarisch reflex. Compound 22 with a 4-amino substituent was equipotent to the reference compounds. In contrast to the benzamide derivatives, the activity resides essentially in the (R) enantiomer (K(i) = 0.15 ¡À 0.05 nM, ID50 = 1.6 mug/kg/iv) and it is demonstrated that the additional carbonyl group is involved in the inversion of the enantioselectivity of the receptor. Conformational studies of (R)-22 demonstrated the presence of a locked structure with 4 minimal energy conformers which were compared to those of (S)-zacopride. The superimposition of the putative active conformers emphasized the presence of a second polar group in the binding site. The fluorescent properties of the compounds were studied and indicate that (R)-22 and its derivatives may be promising tools for the direct visualization of 5-HT3 receptors.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H148N | ChemSpider

In an article, published in an article,authors is Bodnar, Alice L., once mentioned the application of Quality Control of (R)-3-Aminoquinuclidine dihydrochloride, Name is (R)-3-Aminoquinuclidine dihydrochloride,molecular formula is C7H16Cl2N2, is a conventional compound. this article was the specific content is as follows. Quality Control of (R)-3-Aminoquinuclidine dihydrochloride

Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors

A library of benzamides was tested for alpha7 nicotinic acetylcholine receptor (nAChR) agonist activity using a chimeric receptor in a functional, cell-based, high-throughput assay. From this library, quinuclidine benzamides were found to have alpha7 nAChR agonist activity. The SAR diverged from the activity of this compound class verses the 5-HT3 receptor, a structural homologue of the alpha7 nAChR. PNU-282987, the most potent compound from this series, was also shown to open native alpha7 nAChRs in cultured rat neurons and to reverse an amphetamine-induced gating deficit in rats.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H136N | ChemSpider

Application of 123536-14-1, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 123536-14-1, (R)-3-Aminoquinuclidine dihydrochloride, introducing its new discovery.

TRIAZINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC APPLICATION THEREOF

The invention relates to triazine derivatives of general formula (I): Wherein R1, R2 and R3 are as defined herein. The invention also relates to a method for preparing these triazine derivatives and to the therapeutic application thereof.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H133N | ChemSpider

Reference of 123536-14-1, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, Reference of 123536-14-1, molcular formula is C7H16Cl2N2, introducing its new discovery.

NOVEL BENZAMIDE DERIVATIVE AND USE THEREOF

Disclosed are a novel benzamide derivative and pharmaceutical use thereof, and more particularly, a novel benzamide derivative having a structure of Formula 1 or pharmaceutically acceptable salts thereof, and a composition for prevention or treatment of pain or itching including the above material. The novel benzamide derivative and pharmaceutically acceptable salt thereof according to the present invention exhibit excellent pain-suppressive effect and, in particular, pain-suppressive effect in not only a neuropathic animal model but also other models such as a formalin model, and therefore, may be used in suppression of different pains such as nociceptive pain, chronic pain, etc. Further, since it was demonstrated that the present invention displays anti-pruritic efficacy even in an itching model, to which a mechanism and treatment concept established with respect to pain is applied, the present invention may also be effectively used in radical treatment of atopic dermatitis by applying the inventive product to an anti-pruritic composition in order to suppress an initial itching stage and treat symptoms thereof, thus preventing skin damage or inflammation after the scratching stage.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H117N | ChemSpider

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about Formula: C7H16Cl2N2, molcular formula is C7H16Cl2N2, introducing its new discovery. , Formula: C7H16Cl2N2

4-SUBSTITUTED IMIDAZOLES

Compounds of formula I: wherein A and R1 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H103N | ChemSpider

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, Safety of (R)-3-Aminoquinuclidine dihydrochloride, name is (R)-3-Aminoquinuclidine dihydrochloride, introducing its new discovery. Safety of (R)-3-Aminoquinuclidine dihydrochloride

IMMUNOMODULATING OXOPYRRAZOLOCINNOLINES AS CD80 INHIBITORS

N-(l-Aza-bicyclo[2.2.2]oct-3-yI)-4-(6,9-difluoro-3-oxo-1,3-dihydro-pyrazolo[4,3clcinnolin-2-yI)-benzamide is a CD80 antagonist, useful in the treatment of diseases which benefit from immuno-inhibition.

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Quinuclidine – Wikipedia,
Quinuclidine | C7H121N | ChemSpider

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. HPLC of Formula: C7H16Cl2N2, In a patent£¬Which mentioned a new discovery about HPLC of Formula: C7H16Cl2N2

Quinuclidine acrylamides

Compounds of formula I wherein A represents: and R, R1 , R2 , R3 and R4 are as defined in the specification, pharmaceutically acceptable salts thereof,processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders

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Quinuclidine – Wikipedia,
Quinuclidine | C7H126N | ChemSpider