Category: quinuclidine

Truffault, Robert published the artcileCondensation of halogenated derivatives of benzene with unsaturated hydrocarbons and with halogenated derivatives of the latter under the influence of concentrated sulfuric acid as catalyst, Quality Control of 20029-52-1, the publication is Compt. rend. (1938), 676-8, database is CAplus.

Halogenated benzenes condense with olefins, in the presence of concentrated H₂SO₄, in the same way that benzene does (cf. C. A. 30, 4154.8), yielding p-substituted halogenated benzenes. Cyclohexene and PhCl react to form p-chlorocyclohexylbenzene (I), b₁₆ 134°, d₂₀ 1.070, n_D²⁰ 1.5400; M. R. calculated 56.7, found 57.03. With PhBr the product is p-bromocyclohexylbenzene (II), b₁₆ 146°, d₁₉ 1.289, n_D²⁰ 1.5605; M. R., calculated 59.58, found 60.0. Oxidation of I with CrO₃ gave p-ClC₆H₄CO₂H, m. 236°. The Mg derivative of II reacts with CO₂ to form p-cyclohexylbenzoic acid, m. 200°. Allyl chloride (III) and PhCl react to form p-ClC₆H₄CHMeCHCl (IV), b₁₆ 117°, d₂₁ 1.185, n_D²⁰ 1.538; M. R., calculated 49.9, found 49.9. With PhBr the product is p-BrC₆H₄CHMeCH₂Cl (V), b₁₅ 134-5°, d₂₁ 1.416, n_D²¹ 1.558; M. R., calculated 52.8, found 53.2. The structures of IV and V were assigned on the basis of the structures established for the compounds prepared from C₆H₆ and III, loc. cit. Thus, H₂SO₄ may be used to prepare alkylbenzenes having halogenated side chains, which cannot be obtained in the Friedel-Crafts reaction.

Compt. rend. published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C16H18Br2ClN3O3, Quality Control of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Zhang, He published the artcileA new protocol for synthesizing diarylmethanes using a benzyltitanium reagent as a nucleophile, Synthetic Route of 1160556-64-8, the publication is Journal of Chemical Research (2022), 46(2), 17475198221091941, database is CAplus.

The first palladium-catalyzed cross-coupling of various substituted benzyltitaniums with aryl triflates is presented for the synthesis of diarylmethanes in yields of up to 94% through highly selective C-O bond functionalization. The benzyltitaniums act as nucleophiles to realize the C(sp²)-C(sp³) cross-coupling with high efficiency within short reaction times. The reactions proceed at 60°C and show excellent functional group tolerance.

Journal of Chemical Research published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C19H22BNO5, Synthetic Route of 1160556-64-8.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Lu, Xiaoxin published the artcileNumerical modeling and experimental characterization of the AC conductivity and dielectric properties of CNT/polymer nanocomposites, Application In Synthesis of 1761-71-3, the publication is Composites Science and Technology (2020), 108150, database is CAplus.

In this work, we proposed a multiscale numerical model to estimate the elec. conductivity and dielec. constants of the CNT/polymer nanocomposites, taking into account the tunneling effect between neighboring CNTs separated at nanoscale and the frequency-dependent dielec. properties of each components. Finite element method was employed to solve the formulations, and the CNTs were modeled by highly conductive line segments in order to avoid the mesh problems. Experiments have been carried out in carbon nanotubes/epoxy nanocomposites in order to compare to the simulation results. The numerical estimations of the elec. conductivity are in good agreement with the exptl. measurement by network analyzers. Moreover, the calculated dielec. permittivity agrees with the exptl. data for the nanocomposites whose CNT content is beyond percolation threshold. Below percolation threshold, the proposed model also works well in the prediction of dielec. constants when the frequency is over 103Hz.

Composites Science and Technology published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Application In Synthesis of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Dupuy, Stephanie published the artcileTerminal-Selective Functionalization of Alkyl Chains by Regioconvergent Cross-Coupling, Product Details of C28H41N2P, the publication is Angewandte Chemie, International Edition (2016), 55(47), 14793-14797, database is CAplus and MEDLINE.

Hydrocarbons are still the most important precursors of functionalized organic mols., which has stirred interest in the discovery of new C-H bond functionalization methods. We describe herein a new step-economical approach that enables C-C bonds to be constructed at the terminal position of linear alkanes. First, we show that secondary alkyl bromides can undergo in situ conversion into alkyl zinc bromides and regioconvergent Negishi coupling with aryl or alkenyl triflates. The use of a suitable phosphine ligand favoring Pd migration enabled the selective formation of the linear cross-coupling product. Subsequently, mixtures of secondary alkyl bromides were prepared from linear alkanes by standard bromination, and regioconvergent cross-coupling then provided access to the corresponding linear arylation product in only two steps.

Angewandte Chemie, International Edition published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Product Details of C28H41N2P.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Jiang, Kunming published the artcilePalladium-Catalyzed Cross-Coupling Polymerization: A New Access to Cross-Conjugated Polymers with Modifiable Structure and Tunable Optical/Conductive Properties, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, the publication is Macromolecules (Washington, DC, United States) (2018), 51(23), 9662-9668, database is CAplus.

While the synthesis of conjugated polymers has received significant attention, the preparation of cross-conjugated polymers, where the π-electron delocalization cannot extend along the backbone, has received much less success. We have exploited a new catalytic polymerization process and developed the Pd-catalyzed cross-coupling enabled synthesis of cross-conjugated polymers with readily accessible N-tosylhydrazones and aryl halides. A broad scope of cross-conjugated polymers with good processability and thermal stability has been prepared in high yields using dialkylbiarylphospine-Pd precatalysts. Owing to their unique vinyl structures, these polymers could be easily modified in postpolymn. fashions to impart high degrees of structural complexities. Moreover, these materials were shown to have interesting and tunable optical and conductive properties, featuring their great potentials in a variety of applications.

Macromolecules (Washington, DC, United States) published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Xiang, Kang published the artcileTunable C-H arylation and acylation of azoles with carboxylic acids by Pd/Cu cooperative catalysis, Product Details of C13H16O2, the publication is Organic Chemistry Frontiers (2021), 8(11), 2543-2550, database is CAplus.

The direct C-H arylation and acylation of azoles with carboxylic acids were achieved through Pd/Cu cooperative catalysis. Various biaryls and biaryl ketones were selectively produced in good to high yields from the same substrates. The key factor of high chemoselectivity was the choice of a suitable phosphine ligand: biaryls were generated selectively with dppp as the ligand, while biaryl ketones were obtained with high selectivity using dpph or Ph₂PCy as the ligand.

Organic Chemistry Frontiers published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C3H6O2, Product Details of C13H16O2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Li, Yan Mei published the artcileTailored modular assembly derived self-healing polythioureas with largely tunable properties covering plastics, elastomers and fibers, Formula: C13H26N2, the publication is Nature Communications (2022), 13(1), 2633, database is CAplus and MEDLINE.

To impart self-healing polymers largely adjustable dynamicity and mech. performance, here we develop libraries of catalyst-free reversible polythioureas directly from commodity 1,4-phenylene diisothiocyanate and amines via facile click chem. based modular assembly. By using the amine modules with various steric hindrances and flexibilities, the reversible thiourea units acquire triggering temperatures from room temperature to 120 °C. Accordingly, the derived self-healable, recyclable and controlled degradable dynamically crosslinked polythioureas can take effect within wide temperature range. Moreover, mech. properties of the materials can be tuned covering plastics, elastomers and fibers using (i) different assemble modules or (ii) solid-state stretching. Particularly, unidirectional stretching leads to the record-high tensile strength of 266 MPa, while bidirectional stretching provides the materials with biaxial strengths up to over 120 MPa. The mol. mechanism and technol. innovations discussed in this work may benefit promotion and application of self-healing polymers towards greatly diverse demands and scenarios.

Nature Communications published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Formula: C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Zhao, Ziyin published the artcileCytosolic protein delivery via metabolic glycoengineering and bioorthogonal click reactions, Computed Properties of 1353016-70-2, the publication is Biomaterials Science (2021), 9(13), 4639-4647, database is CAplus and MEDLINE.

Cytosolic protein delivery holds great potential for the development of protein-based biotechnologies and therapeutics. Currently, cytosolic protein delivery is mainly achieved with the assistance of various carriers. Herein, we present a universal and effective strategy for carrier-free cytosolic protein delivery via metabolic glycoengineering and bioorthogonal click reactions. Ac₄ManNAz (AAM), an azido-modified N-acetylmannosamine analog, was first employed to label tumor cell surfaces with abundant azido groups via glycometabolism. Then, proteins including RNase A, cytochrome C (Cyt C), and bovine serum albumin (BSA) were covalently modified with dibenzocyclooctyne (DBCO). Based on the highly efficient bioorthogonal click reactions between DBCO and azido, DBCO-modified proteins could be efficiently internalized by azido-labeled cancer cells. RNase A-DBCO could largely maintain its enzymic activity and, thus, led to notable anti-tumor efficacy in HeLa and B16F10 cells in vitro and in B16F10 xenograft tumors in vivo. This study therefore provides a simple and powerful approach for carrier-free protein delivery and would have broad applicability in anti-tumor protein therapy.

Biomaterials Science published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C6H8N2O2, Computed Properties of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Dragovich, Peter S. published the artcileFragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT), Recommanded Product: 4-Cyclohexylbenzoic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(3), 954-962, database is CAplus and MEDLINE.

The fragment-based identification of two novel and potent biochem. inhibitors of the nicotinamide phosphoribosyltransferase (NAMPT) enzyme is described. These compounds (51 and 63) incorporate an amide moiety derived from 3-aminopyridine, and are thus structurally distinct from other known anti-NAMPT agents. Each exhibits potent inhibition of NAMPT biochem. activity (IC₅₀ = 19 and 15 nM, resp.) as well as robust antiproliferative properties in A2780 cell culture experiments (IC₅₀ = 121 and 99 nM, resp.). However, addnl. biol. studies indicate that only inhibitor 51 exerts its A2780 cell culture effects via a NAMPT-mediated mechanism. The crystal structures of both 51 and 63 in complex with NAMPT are also independently described.

Bioorganic & Medicinal Chemistry Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Recommanded Product: 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider