Category: quinuclidine

Neunhoeffer, Otto published the artcileSynthesis and nitration of phenylcyclohexane, Safety of 4-Cyclohexylbenzoic acid, the publication is Journal fuer Praktische Chemie (Leipzig) (1932), 95-109, database is CAplus.

In the preparation of phenyleyelohexane (I) the yield is increased with an excess of C₆H₆; thus, 1 mol. cyclohexyl chloride and 3 mols. C₆H₆ give 0.55 mol. I and 0.18 mol. dicyclohexylbenzene (II), while 12 mols. C₆H₆ gives 0.8 mol. I and 0.08 mol. II. Degradation of I with O₃ gives cyclopentylacetic acid, characterized as the amide, m. 149°. Oxidation of II gives terephthalic acid. Nitration of I in Ac₂O with fuming HNO₃ gives a mixture of p- (III) and o-nitrocyclohexylbenzenes (IV), in the ratio 78: 22; III b_0.6 142°, m. 57°; IV b_0.5 113°, m. 45°. Electrolytic reduction of III gives quantitatively p-cyelohexylaniline; through the diazo reaction this gives 90% of pcyclohexyliodobenzene, b_0.5 117°, m. 4°, and 42% of nitrile, b_0.5 123°, m. 41°; hydrolysis gives p-cyclohexylbenzoic acid, m. 196°. Electrolytic reduction of IV gives o-cyclohexylaniline,b_0.6 106°.m.13°; Acderiv.,m.101°; Bzderiv.,m.154°. III is trimorphic, m. 54°, 56° and 57°.

Journal fuer Praktische Chemie (Leipzig) published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Safety of 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Neunhoeffer, Otto published the artcileTricyclohexylmethane series. III, SDS of cas: 20029-52-1, the publication is Justus Liebigs Annalen der Chemie (1936), 58-65, database is CAplus.

p-Cyclohexylphenylmagnesium iodide and 13 g. Me p-cyclohexylbenzoate give 3 g. p,p’-dicyclohexylbiphenyl (I), m. 205°; some p,p’-dicyclohexylbenzophenone, m. 135°; and as the principal fraction, tri-(p-cyclohexylphenyl)carbinol (II), m. 168°. The action of CO₂ upon the Grignard reagent gives p-cyclohexylbenzoic acid, I and II. II in concentrated H₂SO₄ gives an intensive red-yellow color; II does not react with the usual reagents to form a halogen derivative or a Me ether. The action of Ag upon tricyclohexylmethyl bromide is complete in about 3 months; the action of K-Na gives dicyclohexylcyclohexylidenemethane, m. 52°. The cyclohexyl residue does not favor the formation of free radicals.

Justus Liebigs Annalen der Chemie published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, SDS of cas: 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Sridhar, Arun Srikanth published the artcileEffect of stoichiometry on crosslinked epoxy resin characteristics: structural heterogeneities, topological defects, properties, free volume and segmental mobility, Category: quinuclidine, the publication is Soft Matter (2022), 18(12), 2354-2372, database is CAplus and MEDLINE.

Exptl. studies have shown that changes in stoichiometry (R, ratio of amine groups to epoxy groups) cause considerable variations in the properties of epoxy-amine systems. Rationales based on free volume concepts have been routinely used to address these variations in properties but have hardly been satisfactorily substantiated. Many of these rationales remain as unverified conjectures to date. Substantiating these rationales will certainly bolster our understanding of the structure-stoichiometry-property relationship, but is difficult, due to inherent challenges involved in unambiguously characterizing the structural heterogeneities induced by changes in stoichiometry (structural heterogeneities include compositional distribution in the functionality of monomers, non-uniform dispersion of elastic chains and topol. defects). The aim of the present work is to gain mol.-level insights into this relationship and to verify the rationales that rely on free volume concepts used for addressing the variations in properties with stoichiometry, with the help of all-atom mol. dynamics (MD) simulations. Five epoxy-amine systems with varying R ranging from 0.4 to 3, including the stoichiometric system (R = 1), were considered for these purposes. The properties of interest namely d., glass transition temperature (T_g) and thermal expansion coefficient in the rubbery state (α_rl) of these systems were predicted. The local structure, fractional free volume and segmental mobility of these systems were then subsequently characterized as a function of stoichiometry and the results were analyzed in detail. The role played by defects in properties and fractional free volume was then investigated. The results revealed significant insights into the compositional distribution of monomers with different functionalities as well as offered insights into the dispersion state and mobility of dangling chains, sols and elastic chains in the systems. Further, strong correlations were found between defect composition, fractional free volume at an elevated temperature (600 K) and thermomech. properties (T_g and α_rl) and it was established that the key mechanism underlying these correlations was the plasticization caused by defects. Anal. based on the rule of mixture models showed that these correlations were found to be in good agreement with the interpretations based on free volume concepts. The results also revealed a strong neg. correlation between fractional free volume at room temperature and defect composition, a phenomenon typically associated with the antiplasticization effect.

Soft Matter published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C2H2N4O2, Category: quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

La Scala, John J. published the artcileEffect of methyl and methoxy substituents on dianilines for thermosetting polyimide system, Category: quinuclidine, the publication is High Performance Polymers (2020), 32(7), 801-822, database is CAplus.

4,4-Methylenedianiline (MDA) is widely used in high-temperature polyimide resins, including polymerization of monomer reactants-15. The toxicity of MDA significantly limits the manufacturability using this resin. Modifying the substitution and electronics of MDA could allow for the reduction of toxicity while maintaining the high-performing properties of the materials derived from the modified MDA. The addition of a single Me substituent, methoxy substituent, location of these substituents, and location of the amine relative to the phenolic bridge were modified as were other non-aniline diamines. Various anilines were condensed with paraformaldehyde under acidic conditions to yield dianilines. These dianilines and diamines were reacted with nadic anhydride and 3,3,4,4-benzophenonetetracarboxylic dianhydride in methanol to form the polyamic acid oligomers and heated at elevated temperature to form polyimide oligomers. It was found that the mol. weight of the oligomers derived from MDA alternatives was generally lower than that of MDA oligomers resulting in lower glass transition temperatures (T_gs) and degradation temperatures Addnl., methoxy substituents further reduce the T_g of the polymers vs. Me substituents and reduce the thermal stability of the resin. Methyl-substituted alternatives produced polyimides with similar T_gs and degradation temperatures The toxicity of the MDA alternatives was examined Although a few were identified with reduced toxicities, the alternatives with properties similar to that of MDA also had high toxicities.

High Performance Polymers published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Category: quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Jiang, Yuan published the artcileBiomass-Based Polyureas Derived from Rigid Furfurylamine and Isomannide, Recommanded Product: 4,4-Diaminodicyclohexyl methane, the publication is ACS Applied Polymer Materials (2022), 4(3), 2197-2204, database is CAplus.

Polyureas are important com. polymers that are widely used in construction, automobile industry, military field, and coatings. Biomass-based amines are attractive feedstock in the synthesis of versatile polyureas. Furan-based diamine and isomannide-derived (Im-derived) diamine can be interesting monomers for such materials due to their renewability and intrinsic rigidity, but they have not been extensively studied. Herein, biomass-based polyureas were prepared by polymerizing dicarbamates derived from furfurylamine and isomannide. The dicarbamates were produced in multigram-scale quantities with high purity and yield. A series of polyureas with reasonably high mol. weights were subsequently prepared by condensing the dicarbamates with various diamines. ¹H NMR and ¹³C NMR spectroscopy confirmed the structure of the targeted copolymers. Exploration of thermal behavior by thermogravimetric anal. (TGA) and differential scanning calorimetry (DSC) revealed that the synthetic polyureas showed good thermal stability and glass-transition temperatures (T_g) ranging from 11 to 213°C.

ACS Applied Polymer Materials published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Recommanded Product: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Feng, Xiang-Jun published the artcileSynthesis and Immunomodulating Activity of New Analogues of Fingolimod, Name: 4-Cyclohexylbenzoic acid, the publication is Archiv der Pharmazie (Weinheim, Germany) (2012), 345(2), 93-100, database is CAplus and MEDLINE.

Five new immunomodulators I.HCl (R = H, Et, n-Pr, n-Bu, n-Pen) in which a trans-4-alkyl-substituted cyclohexane replaces the flexible C8 alkyl chain of Fingolimod were synthesized. For in-vitro test, the compounds were dissolved in DMSO as a stock solution and diluted to a desired concentration with RPMI 1640 nutrient solution For in-vivo test, the compounds were prepared in pathogen-free saline containing 0.5% DMSO. These new immunomodulators displayed more potent immunoinhibitory activities in vitro and moderate immunomodulating activities in vivo. They show therapeutic effects on DNFB-induced DTH reaction and inhibitory effects on the antigen-specific T-cell proliferation.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Name: 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Sim, Jee-Hyun published the artcileExperimental and Digimat-FE Based Representative Volume Element Analysis of Dye-Mixed Colored Resin and Carbon Fiber, Application of 4,4-Diaminodicyclohexyl methane, the publication is Polymers (Basel, Switzerland) (2022), 14(5), 1028, database is CAplus and MEDLINE.

Recently, the automobile industry has demanded weight reduction, so research on materials is being actively conducted. Among this research, carbon fiber-reinforced composite materials are being studied a lot in the automobile industry due to their excellent mech. properties, chem. resistance, and heat resistance. However, carbon fiber-reinforced composite materials have disadvantages, in that they are not free from color selection, and have weak interfacial bonding strength. In this study, a colored epoxy resin was prepared by mixing epoxy-which is a thermosetting resin according to the pigment concentration (0.1, 0.3, 0.5, 1.0 wt%)-and curing shrinkage. Thermal expansion characteristics were analyzed and the concentration of 0.5 wt% pigment showed the lowest shrinkage and thermal expansion characteristics. In addition, to measure the interfacial shear strength (IFSS) of the carbon fiber and the colored epoxy resin, the IFSS was obtained by performing a microdroplet debonding test, and the strength of the pigment concentration of 0.5 wt% was reduced to a relatively low level. Through these experiments, it was determined that an epoxy resin in which 0.5 wt% pigment is mixed is the optimal condition. Finally, using the composite material modeling software (Digimat 2020.0), the representative volume element (RVE) of the meso-scale was set, and interfacial properties of carbon fibers and colored epoxy resins were analyzed by interworking with general-purpose finite element anal. software (Abaqus CAE).

Polymers (Basel, Switzerland) published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C17H19N3O6, Application of 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Fong, Darryl published the artcileDecoration of Polyfluorene-Wrapped Carbon Nanotubes via Strain-Promoted Azide-Alkyne Cycloaddition, Safety of Dbco-acid, the publication is Macromolecules (Washington, DC, United States) (2018), 51(3), 755-762, database is CAplus.

Developing methodologies that can efficiently decorate carbon nanotube surfaces with various mol. structures while avoiding damage to nanotube optoelectronic properties is an ongoing challenge. Here, we outline a methodol. to perform chem. on the nanotube surface without perturbing optoelectronic properties. Reactive, noncovalently functionalized polymer-nanotube complexes were prepared using polyfluorene with azide groups in its side chains. The azides enable strain-promoted azide-alkyne cycloaddition to occur between polymer-nanotube complexes and small mols. or polymers derivatized with a strained cyclooctyne. This reaction was found to occur efficiently at room temperature, without any catalyst or byproduct removal required. The reaction was monitored by IR spectroscopy via the disappearance of the polymer azide stretch at ∼2090 cm^-1, and this chem. resulted in no damage to the nanotube sidewall, as evidenced by Raman spectroscopy. The azide-containing polyfluorene was used to prepare an enriched dispersion of semiconducting carbon nanotubes in organic media, which could then be redispersed in aqueous solution post-click with strained cyclooctyne-functionalized poly(ethylene glycol). Taking advantage of the ability to preserve optoelectronic properties, solvatochromism of an identical subset of semiconducting carbon nanotubes was studied using absorption, fluorescence, and Raman spectroscopy. It was found that, in aqueous media, fluorescence was nonuniformly quenched among the different semiconducting species and that there was a significant red-shift in the emission of all nanotubes in D₂O relative to nonpolar toluene.

Macromolecules (Washington, DC, United States) published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Safety of Dbco-acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Fan, Zhengning published the artcileVisible-Light-Induced Catalyst-Free Carboxylation of Acylsilanes with Carbon Dioxide, Quality Control of 20029-52-1, the publication is Organic Letters (2021), 23(6), 2303-2307, database is CAplus and MEDLINE.

Intermol. carbon-carbon bond formation between acylsilanes and carbon dioxide (CO₂) was achieved by photoirradiation under catalyst-free conditions. In this reaction, siloxycarbenes generated by photoisomerization of the acylsilanes added to the C=O bond of CO₂ to give α-ketocarboxylates, which underwent hydrolysis to afford α-ketocarboxylic derivatives in good yields. Control experiments suggest that the generated siloxycarbene is likely to be from the singlet state (S₁) of the acylsilane and the addition to CO₂ is not in a concerted manner.

Organic Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Quality Control of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Lai, Chiu-Chun published the artcileSynthesis and properties of low-crystallinity nylon 6 with high transparency and low hygroscopicity containing adipic acid, Safety of 4,4-Diaminodicyclohexyl methane, the publication is Modern Physics Letters B (2020), 34(7/9), 2040005, database is CAplus.

In this research, a series of amorphous nylons 6 were prepared by introducing adipic acid and different structure amines into the copolymerization with caprolactam. The effects including thermal properties, crystallinity, dynamic mech. properties, optical properties, and water absorption of different copolymerization structure and copolymerization ratio on the properties of nylon 6 were investigated. The results show the m.p. and thermal cracking temperature Td 5 of nylon 6 are, resp., between 179°C and 217°C and 278°C to 336°C. Nylon 6 structure introducing a Me side chain is more effective than a meta-benzene ring, a meta-cycloalkyl, and bicycloalkyl groups, so CAMM and CAI have the lowest crystallinity.

Modern Physics Letters B published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Safety of 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider