Category: quinuclidine

Silverberg, Lee J. published the artcileSynthesis and spectroscopic properties of 2,3-diphenyl-1,3-thiaza-4-one heterocycles, Product Details of C6H10O2S, the publication is International Journal of Chemistry (Toronto, ON, Canada) (2015), 7(2), 150-162, database is CAplus.

Synthetic and spectroscopic data (¹H NMR, ¹³C NMR, IR, UV/Vis) for a series of six 2,3-diphenyl-1,3-thiaza-4-one heterocycles which differed in ring size and substitution was reported. The results showed that there are significant differences in spectroscopic signals common to all six compounds Distinctions was made among the compounds using the IR absorbance of the C4 carbonyl and the ¹H NMR signal at C2, and to a lesser extent the ¹³C NMR signal at C4 and the UV/Vis spectrum.

International Journal of Chemistry (Toronto, ON, Canada) published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C10H16Br3N, Product Details of C6H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Rawat, Ajay Singh published the artcileSynthesis of Donepezil Hydrochloride via Chemoselective Hydrogenation, Related Products of quinuclidine, the publication is Organic Process Research & Development (2013), 17(12), 1617, database is CAplus.

A simple and highly chemoselective and cost-effective process for the synthesis of Donepezil 1 has been developed for com. production In the process, the exocyclic double bond is mainly targeted for catalytic hydrogenation in the presence of an N-benzyl group using sulfur, nitrogen, and phosphorous catalyst modifiers. In some cases, catalytic hydrogenation with Pd on charcoal also produced an undesired side product along with the main product due to over reduction Removal of these impurities by crystallization, column chromatog., or other means of purification makes the process tedious and lengthy, and sometimes it is difficult to achieve the impurity limit as per International Conference on Harmonisation (ICH) guidelines for active pharmaceutical ingredients. In the present investigation we report the synthesis of Donepezil 1 in pure form wherein the debenzyl impurity is within the acceptable limits.

Organic Process Research & Development published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H10O2S, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Wu, Feng published the artcileSwelling-strengthening hydrogels by embedding with deformable nanobarriers, Recommanded Product: Dbco-acid, the publication is Nature Communications (2020), 11(1), 4502, database is CAplus and MEDLINE.

Biol. tissues, such as muscle, can increase their mech. strength after swelling due to the existence of many biol. membrane barriers that can regulate the transmembrane transport of water mols. and ions. Oppositely, typical synthetic materials show a swelling-weakening behavior, which always suffers from a sharp decline in mech. strength after swelling, because of the dilution of the network. Here, we describe a swelling-strengthening phenomenon of polymer materials achieved by a bioinspired strategy. Liposomal membrane nanobarriers are covalently embedded in a crosslinked network to regulate transmembrane transport. After swelling, the stretched network deforms the liposomes and subsequently initiates the transmembrane diffusion of the encapsulated mols. that can trigger the formation of a new network from the preloaded precursor. Thanks to the tough nature of the double-network structure, the swelling-strengthening phenomenon is achieved to polymer hydrogels successfully. Swelling-triggered self-strengthening enables the development of various dynamic materials.

Nature Communications published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C7H6Cl2, Recommanded Product: Dbco-acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

McNelles, Stuart A. published the artcileStrain-Promoted Azide-Alkyne Cycloaddition-Mediated Step-Growth Polymerization, Application In Synthesis of 1353016-70-2, the publication is Macromolecules (Washington, DC, United States) (2019), 52(19), 7183-7187, database is CAplus.

The development of new polymerization techniques enables the preparation of new polymers with unique functionalities, structures, and architectures. Here, we report a bifunctional monomer based on the strained dibenzoazacyclooctyne (DBCO) structure that efficiently polymerizes with several bifunctional azide comonomers. The reactions proceed to full conversion in under 5 min and routinely results in polymers with mol. weights above 50 kDa, as determined by size-exclusion chromatog. and ¹H NMR. The polymers were found to retain reactive chain ends, enabling control of mol. weight via monomer addition or titration of monomer stoichiometry. The DBCO-based monomer was further investigated in the synthesis of crosslinked polymers using a trifunctional azide crosslinker, which formed gels at concentrations in excess of 50 mM, as suppression of intramol. cyclization was necessary. This strategy allows for the rapid and efficient preparation of polymers and crosslinked gels without heat, light, catalysts, initiators, or any byproducts.

Macromolecules (Washington, DC, United States) published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Application In Synthesis of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

McNelles, Stuart A. published the artcileHighly Efficient Multigram Synthesis of Dibenzoazacyclooctyne (DBCO) without Chromatography, COA of Formula: C19H15NO3, the publication is Organic Process Research & Development (2019), 23(12), 2740-2745, database is CAplus.

The synthesis of 4-[11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl]-4-oxobutanoic acid, also known as dibenzoazacyclooctyne (DBCO) or aza-dibenzocyclooctyne (ADIBO), was optimized for large-scale preparations of at least 10 g with an overall yield of 42%.

Organic Process Research & Development published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, COA of Formula: C19H15NO3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Wolosz, Dominik published the artcileEnvironmentally Friendly Synthesis of Urea-Free Poly(carbonate-urethane) Elastomers, Name: 4,4-Diaminodicyclohexyl methane, the publication is Macromolecules (Washington, DC, United States) (2022), 55(12), 4995-5008, database is CAplus.

This work presents an eco-friendly synthetic pathway toward non-isocyanate poly(carbonate-urethane)s (NIPCUs) obtained from carbon dioxide and its simple derivatives-organic carbonates. Bis(hydroxyalkyl carbamate)s synthesized from ethylene carbonate and appropriate α,ω-diamines were used as polyurethane hard segment precursors while oligocarbonate diols as soft segment ones. The structures and properties of the obtained NIPCUs were explored by means of ¹H NMR, ¹³C NMR, and FT-IR spectroscopies, MALDI-ToF mass spectrometry, DSC, and mech. testing. Based on spectroscopic data as well as model reactions, it was demonstrated that the formation of the urea bonds was suppressed due to the presence of carbonate moieties. The reaction of urea bonds with carbonate residues led to urethane group formation. In addition, the influence of the polyurethane structure on the mech. and thermal properties of the obtained polymers was studied. The obtained NIPCUs exhibited mech. properties comparable to conventional polyurethane elastomers (e.g., a tensile strength of 32 MPa and an elongation at break of 800%). The described synthetic route is an straightforward way toward the replacement of conventional polyurethanes with environmentally friendly ones.

Macromolecules (Washington, DC, United States) published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C9H8O4, Name: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Urlam, Murali K. published the artcileDevelopment of new N-arylbenzamides as STAT3 dimerization inhibitors, Computed Properties of 20029-52-1, the publication is MedChemComm (2013), 4(6), 932-941, database is CAplus and MEDLINE.

The O-tosylsalicylamide S3I-201 (10) was used as a starting point for design and synthesis of novel STAT-3 dimerization inhibitors with improved drug-like qualities. The phosphonic acid 12d and salicylic acids 13f, 13g with a shorter amide linker lacking the O-tosyl group had improved STAT-3 inhibitory activity. The equivalent potencies observed by the replacement of phosphonic acid moiety of 12d with 5-amino-2-hydroxybenzoic acid group as in 13f further validates 5-amino-2-hydroxybenzoic acid as a phosphotyrosine mimic. The salicylic acid 13f displayed improved whole cell activity. The focused library of salicylic acids 13 with benzamide linker indicated that hydrophobic heptyl and cyclohexyl are the best tolerated R groups and a biphenyl ether (as the Ar group) significantly contributes to STAT3 inhibitory activity. Our docking studies indicated that the acidic groups of 12d, 13f and 13g interact in the p-Tyr-705 binding site in a broadly similar manner, while the phenoxybenzoyl group and the cyclohexylbenzyl group occupying pY+1 and pY-X hydrophobic pockets resp. The in vitro and cell based potency of 13f warrants further development of this scaffold as STAT3 inhibitors.

MedChemComm published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C18H28B2O4, Computed Properties of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Blaser, Hans Ulrich published the artcileHaving Fun (and Commercial Success) with Josiphos and Related Chiral Ferrocene Based Ligands., Product Details of C28H41N2P, the publication is Helvetica Chimica Acta (2021), 104(1), e2000192, database is CAplus.

The Josiphos ligand family is arguably one of the most versatile classes of chiral ligands with a wide range of applications, including one of the two largest known enantioselective catalytic hydrogenations. In this personal account, we take a look back at the beginning and describe the role Antonio Togni has played to reach this point and the significance of his contributions for the com. success, especially concerning todays ligand business of Solvias. This seems a fitting point in time in light of Antonios statement on his ETH home page that he is working as a professor at this institution since 1992 (a few more months to go), not looking for a job′ and that the three authors have already retired for some time (H. U. B.) or are about to retire soon (B. P., F. S.).

Helvetica Chimica Acta published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Product Details of C28H41N2P.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Sathyanarayana, Pochampalli published the artcileCopper catalyzed oxygen assisted C(CNOH)-C(alkyl) bond cleavage: a facile conversion of aryl/aralkyl/vinyl ketones to aromatic acids, SDS of cas: 20029-52-1, the publication is Organic & Biomolecular Chemistry (2015), 13(37), 9681-9685, database is CAplus and MEDLINE.

A novel copper-catalyzed aerobic oxidative C(NOH)-C(alkyl) bond cleavage reaction of aryl/aralkyl/vinyl ketones for the synthesis of aromatic/acrylic acids is described. A series of ketones having aryl/aralkyl/vinyl at the one end and Me to any higher alkyl at the other end can be selectively cleaved and converted into the corresponding acids via oxime intermediates.

Organic & Biomolecular Chemistry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, SDS of cas: 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Francisco, Vitor published the artcileA high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies, Product Details of C13H26N2, the publication is Methods (Amsterdam, Netherlands) (2021), 13-25, database is CAplus and MEDLINE.

RNA-based therapies are highly selective and powerful regulators of biol. functions. Non-viral vectors such as nanoparticles (NPs) are very promising formulations for the delivery of RNA-based therapies but their cell targeting, cell internalization and endolysomal escape capacity is rather limited. Here, we present a methodol. that combines high-throughput synthesis of light-triggerable NPs and a high-content imaging screening to identify NPs capable of efficiently delivering different type of RNAs. The NPs were generated using polymers synthesized by Michael type addition reactions and they were designed to: (i) efficiently complex coding (mRNAs) and non-coding (miRNAs and/or lncRNAs) RNA mols., (ii) allow rapid cell uptake and cytoplasmic release of RNA mols. and (iii) target different cell types based on their composition Furthermore, light-responsive domains were attached to the polymers by distinctive methods to provide diverse disassembly strategies. The most efficient formulations were identified using cell-based assays and high-content imaging anal. This strategy allows precise delivery of RNA-based therapies and provides an effective design approach to address critical issues in non-viral gene delivery.

Methods (Amsterdam, Netherlands) published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Product Details of C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider