Category: quinuclidine

Yang, Ya-Jun published the artcileDesign, synthesis and biological evaluation of dipeptides as novel non-covalent 20S proteasome inhibitors, Recommanded Product: 4-Cyclohexylbenzoic acid, the publication is Journal of Asian Natural Products Research (2021), 23(5), 436-451, database is CAplus and MEDLINE.

Based on the interaction modes of the natural 20S proteasome inhibitors , we have previously discovered a dipeptide . To explore the SAR around compound , we designed and synthesized a series of dipeptides () with a fragment-based strategy. Among them, nine compounds showed significant inhibitory activities against the chymotrypsin-like activity of human 20S proteasome with IC₅₀ values at the submicromolar level, which were comparable or even superior to the parent compound Meanwhile, they displayed no significant inhibition against trypsin-like and caspase-like activities of 20S proteasome. The results suggested the feasibility to design dipeptides as novel and potent 20S proteasome inhibitors.

Journal of Asian Natural Products Research published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C12H14IN, Recommanded Product: 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Akinbobuyi, Babatope published the artcileSynthesis and immunostimulatory activity of substituted TLR7 agonists, Application In Synthesis of 1353016-70-2, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(17), 4246-4249, database is CAplus and MEDLINE.

Fifteen new substituted 9-benzyladenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds, were analyzed for TLR7 activity and for the selective stimulation of B cell proliferation. Several functionalized derivatives exhibit significant activity, suggesting their potential for use as vaccine adjuvants.

Bioorganic & Medicinal Chemistry Letters published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Application In Synthesis of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Hui, Xiang published the artcileHighly efficient synthesis of novel bio-based pentamethylene dicarbamate via carbonylation of pentanediamine with ethyl carbamate over well-defined titanium oxide catalysts, Category: quinuclidine, the publication is Catalysis Science & Technology (2022), 12(7), 2315-2327, database is CAplus.

Carbonylation of pentanediamine (PDA) is a green and effective route for the synthesis of pentamethylene dicarbamate (PDC), an important intermediate compound for the preparation of polyurethanes (PUs) and other chems. In this work, TiO₂-101 and TiO₂-110 catalysts, with preferential exposure of (101) and (110) facets, resp., were prepared and studied for the carbonylation of diamines with Et carbamate (EC) to give dicarbamates, e.g., EtO₂C(CH₂)₇NHCO₂Et and I. The catalysts were characterized by various techniques, including XRD, BET, SEM, TEM, XPS, NH₃-TPD and in situ FTIR. The characterization results indicated that TiO₂ catalysts with exposed (110) and (101) facets were synthesized successfully. The overall results suggested that the (101) facets on the TiO₂ surface provide high amounts of surface Lewis acid sites that played a pivotal role in PDC formation, which gave a conversion and yield both up to 99% under optimized conditions. In situ FTIR spectroscopy clearly revealed that polyurea as an intermediate was formed in the reaction and subsequently converted to PDC catalyzed by the TiO₂ catalyst. Furthermore, the DFT results showed that the conversion of polyurea to PDC over the (101) facets was more prone to occur than the (110) facets due to the lower reaction energy barrier. In addition, the TiO₂-101 catalyst displayed excellent stability without an obvious activity decline after five cycles.

Catalysis Science & Technology published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Category: quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Wang, Yaxin published the artcileVisible-Light-Promoted Site-Specific and Diverse Functionalization of a C(sp³)-C(sp³) Bond Adjacent to an Arene, Synthetic Route of 20029-52-1, the publication is ACS Catalysis (2020), 10(12), 6603-6612, database is CAplus.

A strategy for inert C-C bond functionalization is reported. Site-specific cleavage and functionalization of saturated C(sp3)-C(sp3) bond via a visible-light-induced radical process was achieved. The general features of this reaction are: 1-Both linear and cyclic C(sp3)-C(sp3) bonds with a vicinal arene can be specifically functionalized; 2-One carbon is converted into ketone, and the another can be tunably converted into nitrile, peroxide or halide; 3-The typical conditions includes: 1.0 mol% Ru(bpy)3Cl2, 1.0 or 5.0 equiv of Zhdankin reagent, white CFL (24 W), open flask and room temperature These reactions offer a powerful tool to modify carbon skeletons that are intractable by conventional methods. Good selectivity and functional group tolerance, together with mild and open air conditions make these transformations valuable and attractive.

ACS Catalysis published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C9H10O3S, Synthetic Route of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Cheng, Ho Fung published the artcileElectron-Equivalent Valency through Molecularly Well-Defined Multivalent DNA, Related Products of quinuclidine, the publication is Journal of the American Chemical Society (2021), 143(4), 1752-1757, database is CAplus and MEDLINE.

Oligonucleotide-functionalized nanoparticles (NPs), also known as “programmable atom equivalent” (PAEs), have emerged as a class of versatile building blocks for generating colloidal crystals with tailorable structures and properties. Recent studies have shown that, at small size and low DNA grafting d., PAEs can also behave as “electron equivalent” (EEs), roaming through and stabilizing a complementary PAE sublattice. However, it has been challenging to obtain a detailed understanding of EE-PAE interactions and the underlying colloidal metallicity because there is inherent polydispersity in the number of DNA strands on the surfaces of these NPs; thus, the structural uniformity and tailorability of NP-based EEs are somewhat limited. Herein, we report a strategy for synthesizing colloidal crystals where the EEs are templated by small mols., instead of NPs, and functionalized with a precise number of DNA strands. When these molecularly precise EEs are assembled with complementary NP-based PAEs, X-ray scattering and electron microscopy reveal the formation of three distinct “metallic” phases. Importantly, we show that the thermal stability of these crystals is dependent on the number of sticky ends per EE, while lattice symmetry is controlled by the number and orientation of EE sticky ends on the PAEs. Taken together, this work introduces the notion that, unlike conventional electrons, EEs that are mol. in origin can have a defined valency that can be used to influence and guide specific phase formation.

Journal of the American Chemical Society published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Koshel, S. G. published the artcileSynthesis of biphenylpolycarboxylic acids. II. Oxidation of cyclohexyltoluenes and methylbiphenyls to carboxylic acids, Category: quinuclidine, the publication is Zhurnal Organicheskoi Khimii (1992), 28(2), 363-6, database is CAplus.

Oxidation of 2-, 3-, and 4-cyclohexyltoluenes and -PhC₆H₄Me with O at 90° in AcOH containing Co(OAc)₂-MeCHO or Mn(OAc)₂-NaBr, resp., gave the corresponding title acids in 95-98% yield. The substrate reactivity increased in the stated order of isomers, owing to steric hindrance in the ortho isomers.

Zhurnal Organicheskoi Khimii published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Category: quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Yennawar, Hemant P. published the artcile6,7-Diphenyl-5-thia-7-azaspiro[2.6]nonan-8-one, Category: quinuclidine, the publication is Acta Crystallographica, Section E: Structure Reports Online (2013), 69(11), o1659, database is CAplus and MEDLINE.

The asym. unit of the title compound, C₁₉H₁₉NOS, contains two independent mols. (A and B), in both of which the 1,3-thiazepan-4-one ring adopts a chair-type conformation. The dihedral angles between the two Ph rings are 65.28(8) and 60.31(9)° for mols. A and B, resp. In the crystal, mols. are linked by weak C-H···O interactions, resulting in a three-dimensional network. Crystallog. data and at. coordinates are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C28H18O4, Category: quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Newman-Stonebraker, Samuel H. published the artcileUnivariate classification of phosphine ligation state and reactivity in cross-coupling catalysis, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, the publication is Science (Washington, DC, United States) (2021), 374(6565), 301-308, database is CAplus and MEDLINE.

Minimal buried volume of the phosphine ligands was correlated with the stoichiometry of nickel and palladium complexes and catalytic activity in Suzuki, Heck and Buchwald amination reactions. Chemists often use statistical anal. of reaction data with mol. descriptors to identify structure-reactivity relationships, which can enable prediction and mechanistic understanding. In this study, we developed a broadly applicable and quant. classification workflow that identifies reactivity cliffs in 11 Ni- and Pd-catalyzed cross-coupling datasets using monodentate phosphine ligands. A distinctive ligand steric descriptor, min. percent buried volume [%Vbur (min)], is found to divide these datasets into active and inactive regions at a similar threshold value. Organometallic studies demonstrate that this threshold corresponds to the binary outcome of bisligated vs. monoligated metal and that %Vbur (min) is a phys. meaningful and predictive representation of ligand structure in catalysis.

Science (Washington, DC, United States) published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Chen, Min published the artcileAntifouling peptides combined with recognizing DNA probes for ultralow fouling electrochemical detection of cancer biomarkers in human bodily fluids, SDS of cas: 1353016-70-2, the publication is Biosensors & Bioelectronics (2022), 114162, database is CAplus and MEDLINE.

Herein, a universal strategy for the construction of highly sensitive and low fouling biosensors was proposed based on antifouling peptides conjugated with recognizing DNA probes. The peptide-DNA conjugate was formed through a reagent-free click reaction between a typical DNA aptamer modified with 5-dibenzocyclooctyne (DBCO) and the designed antifouling peptide terminated with biotin and the azide group at its two ends. With the assistance of streptavidin (SA), the electrochem. biosensor was constructed via immobilization of the straight peptides and peptide-DNA conjugates in sequence onto the electrode surface modified with electrodeposited poly(3,4-ethylenedioxythiophene) (PEDOT) and gold nanoparticles (AuNPs). The prepared biosensor exhibited excellent antifouling performances in various human bodily fluids such as serum, sweat and urine, with a wide linear response range for CA125 from 0.01 U mL-1 to 1000 U mL-1, and a low limit of detection of 0.003 U mL-1. Combining the advantages of the antifouling peptide and recognizing DNA probe, this sensing strategy was capable of assaying CA125 in undiluted human serum, and it also offered a highly promising way for the development of different antifouling biosensors through the conjugation of antifouling peptides with various DNA probes.

Biosensors & Bioelectronics published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, SDS of cas: 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Sun, Yong-Hui published the artcileA diversity-oriented synthesis of bioactive benzanilides via a regioselective C(sp²)-H hydroxylation strategy, SDS of cas: 20029-52-1, the publication is Chemical Science (2016), 7(3), 2229-2238, database is CAplus and MEDLINE.

Hydroxylated benzanilides such as I (R¹ = H, 4-Me, 3-F, etc.; R² = H, 4-Me, 3-F, etc.; R³ = Me, Et, Bn) were prepared by chemo- and regioselective C(sp²)-H hydroxylation using palladium and ruthenium catalysts. Ruthenium catalysts yielded N-aryl hydroxybenzamides, while palladium catalysts yielded N-hydroxyaryl benzamides. Computational investigations reveals that the regioselectivity is controlled mainly by both steric and electronic factors. Steric effects determine the regioselective outcomes in the Ru-catalyzed reaction, while electronic effects are dominant in the Pd-catalyzed reaction.

Chemical Science published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C48H47FeP, SDS of cas: 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider