Category: quinuclidine

Yamaoka, Nagahisa published the artcileIdentification of novel plasminogen activator inhibitor-1 inhibitors with improved oral bioavailability: Structure optimization of N-acylanthranilic acid derivatives, Product Details of C13H16O2, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(4), 809-813, database is CAplus and MEDLINE.

Novel plasminogen activator inhibitor-1 (PAI-1) inhibitors with highly improved oral bioavailability were discovered by structure-activity relationship studies on N-acyl-5-chloroanthranilic acid derivatives Because lipophilic N-acyl groups seemed to be important for the anthranilic acid derivatives to strongly inhibit PAI-1, synthesis of compounds in which 5-chloroanthranilic acid was bound to a variety of highly lipophilic moieties with appropriate linkers was investigated. As the result it appeared that some of the derivatives possessing aryl- or heteroaryl-substituted Ph groups in the acyl chain had potent in vitro PAI-1 inhibitory activity. Oral absorbability of typical compounds was also evaluated in rats, and three compounds which have diverse chem. structure with each other, e.g., I, were selected for further pharmacol. evaluation.

Bioorganic & Medicinal Chemistry Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C2H3N3, Product Details of C13H16O2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Rahimi, AliReza published the artcileAmphiphilic marine coating systems of self-stratified PDMS-PEG surfaces with an epoxy-polyurethane matrix, Computed Properties of 1761-71-3, the publication is Journal of Coatings Technology and Research (2022), 19(3), 795-812, database is CAplus.

Marine coatings protect submerged surfaces from the neg. effects of biofouling. In this work, we demonstrate a new method to prepare self-stratified, amphiphilic glycidyl-carbamate (GC)-based (epoxy urethane-based) coatings (AmpSiGC coatings) that have fouling-release properties making them suitable for marine use. The prepared coating systems are unique and durable in character as the bulk coating takes advantage of both epoxy and urethane functionalities while the surface is comprised of both hydrophilic and hydrophobic domains, granting it an amphiphilic characteristic. The exptl. approach aimed to evaluate several factors that influence coating performance, including mol. weight of poly(ethylene glycol) (PEG) and PDMS moieties, ratio of hydrophobic (PDMS) and hydrophilic (PEG) components in the system, and the effect of different curing agents. The results demonstrated that polymeric chains of 10,000 M_n PDMS and 750 M_n PEG at 10-15 weight% each offer substantially improved or comparable fouling-release performance in comparison to com. marine coatings. This paper reports on the facile synthesis and characterization of the GC resin and GC prepolymers using FTIR and epoxy titrations; surface characterization of the coatings using ATR-FTIR, XPS, and AFM; and fouling-release assessment of the surfaces using laboratory biol. assays with the barnacle Amphibalanus amphitrite, the algae Ulva linza and Navicula incerta, and the bacteria Cellulophaga lytica. Several of the AmpSiGC coatings exhibited promising performance, which were better or comparable to the internal and com. reference coatings. The performance of the systems was dependent on all of the factors considered in this study.

Journal of Coatings Technology and Research published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Computed Properties of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Yang, Yang published the artcilePalladium-Catalyzed Completely Linear-Selective Negishi Cross-Coupling of Allylzinc Halides with Aryl and Vinyl Electrophiles, Computed Properties of 1160556-64-8, the publication is Angewandte Chemie, International Edition (2013), 52(52), 14098-14102, database is CAplus and MEDLINE.

A linear-selective Negishi coupling reaction was developed and the synthesis of the target compounds was achieved by a reaction of (allyl)zinc reagents [i.e., (prenyl)zinc bromide, (farnesyl)zinc, etc.] with aryl halides, heteroaryl halides, vinyl halides. The reaction features mild reaction conditions and a broad reactant scope with respect to aryl halides and vinyl halides and (allyl)zinc coupling components. Under optimized reaction conditions [2′-(amino-κN)[1,1′-biphenyl]-2-yl-κC][2′-(dicyclohexylphosphino-κP)-N²,N²,N⁶,N⁶-tetramethyl[1,1′-biphenyl]-2,6-diamine](methanesulfonate-κO)palladium was used as a catalyst. This synthetic approach was applied to the preparation of 6-methyl-3-(3-methyl-2-buten-1-yl)-9H-carbazol-2-ol (siamenol).

Angewandte Chemie, International Edition published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C18H20N2O12, Computed Properties of 1160556-64-8.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Doi, Marina published the artcilePhotoluminescence properties of copolyimides containing naphthalene core and analysis of excitation energy transfer between the dianhydride moieties, Name: 4,4-Diaminodicyclohexyl methane, the publication is Journal of Photopolymer Science and Technology (2021), 34(5), 423-430, database is CAplus.

The photoluminescence (PL) properties of semi-aromatic polyimide (PI) films and their model compounds (MCs) prepared from dianhydrides having a rigid naphthalene core were analyzed. The PMMA-dispersed MC and copolymerized PI (CoPI) films derived from 2,3,6,7-naphthalenetetracarboxylic dianhydride (NTDA) exhibited long-lived phosphorescence owing to the suppression of mol. motion by the rigidity of a naphthalene core. Addnl., the PMMA-dispersed MC and the CoPI films derived from 1,5-dibromo derivative of NTDA (DBrNT) exhibited room-temperature phosphorescence due to the enhancement of spin-orbit coupling by bromine atoms. The photophys. processes of the CoPI films prepared from NTDA/DBrNT and 4,4′-oxydiphtalic dianhydride (ODPA) in which the latter absorption band is located at a shorter wavelength than the former were analyzed. After UV irradiation, efficient excitation energy transfer occurs from the ODPA to NTDA/DBrNT moieties, and only the emission from the latter moieties was observed These results demonstrate that the CoPI films derived from two dianhydrides absorbing different UV wavelengths can be used as spectral conversion films that convert a wide range of UV-light into longer wavelength visible light.

Journal of Photopolymer Science and Technology published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Name: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Shevchenko, V. P. published the artcileInfluence of the nature of activated hydrogen isotope species on the isotope exchange efficiency, with preparation of labeled sodium 4-phenylbenzoate as example, COA of Formula: C13H16O2, the publication is Radiochemistry (Moscow, Russian Federation) (2015), 57(4), 431-438, database is CAplus.

The influence of the nature of activated hydrogen isotope species on the isotope exchange efficiency was studied with preparation of labeled sodium 4-phenylbenzoate as example. The effect of various factors on the deuterium labeling of this compound was examined At temperatures lower than 200 °C, deuterium is mainly incorporated into the Ph moiety, i.e., under these conditions activated hydrogen species are incorporated by the electrophilic mechanism. In the range from 260 to 300 °C, the mean number of deuterium atoms incorporated into 4-phenylbenzoic acid mols. becomes approx. constant (about 8.22 deuterium atoms per mol.). At these temperatures, deuterium is efficiently incorporated both into the Ph fragment and into the benzoic acid residue, which suggests the prevalence of the radical substitution mechanism under these conditions. At temperatures at which the isotope substitution in sodium 4-phenylbenzoate occurs by the electrophilic mechanism, 4-cyclohexylbenzoic acid is formed concurrently, i.e., the maximal yield of 4-cyclohexylbenzoic acid can be reached at temperatures that are most favorable for the isotope exchange by the electrophilic mechanism. At 200 °C, the content of 4-cyclohexylbenzoic acid in the reaction mixture reaches a maximum A sharp increase in the contribution of the radical mechanism of the process at higher temperatures led to a decrease in the yield of 4-cyclohexylbenzoic acid. It was assumed that clusters of activated hydrogen species and electrons, solvated on the support surface, undergo rearrangement with increasing temperature Whereas the major role in labeling by the electrophilic mechanism is played by hydrogen isotope cations, at higher temperatures hydrogen isotope cations interact with electrons to form hydrogen atoms, which become active participants of the exchange process.

Radiochemistry (Moscow, Russian Federation) published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C11H14O4, COA of Formula: C13H16O2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider