Category: quinuclidine

Wang, Haibo published the artcilePincer thioamide and pincer thioimide palladium complexes catalyze highly efficient Negishi coupling of primary and secondary alkyl zinc reagents at room temperature, Quality Control of 20029-52-1, the publication is Chemistry – A European Journal (2009), 15(6), 1499-1507, database is CAplus and MEDLINE.

Two pincer thioamide and thioimide Pd^II complexes were synthesized from 2,6-bis(butylaminothiocarbonyl)pyridine and their structures were confirmed by X-ray anal. Both complexes were found to be efficient catalysts for Negishi couplings involving primary and secondary alkylzinc reagents bearing β-hydrogen atoms. At a concentration of 0.1- 0.5 mol% both catalysts readily promoted reactions at room temperature or even at 0 °C. The operational simplicity of these processes, in conjunction with the easy accessibility of both catalysts and substrates, promises synthetic utility of this new methodol. An experiment on a scale of 19.35 g carried out at very low catalyst loading (turnover number: 6100 000) highlighted the potential application of the catalytic system. Monoalkyl and dialkylzinc reagents displayed different reactivities and selectivities in reactions with aryl iodides, and isomerization in reactions involving acyclic secondary alkyl zinc derivatives was suppressed by using appropriate amounts of dialkylzinc reagents. Based on preliminary kinetic profiles and reaction evidence, three possible pathways are proposed for the reactions involving acyclic secondary alkyl zinc reagents to rationalize the difference between monoalkyl and dialkyl zinc derivatives

Chemistry – A European Journal published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C20H17FO4S, Quality Control of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Liu, Xue published the artcileTrifluoromethylation of Benzoic Acids: An Access to Aryl Trifluoromethyl Ketones, Product Details of C13H16O2, the publication is Organic Letters (2021), 23(12), 4930-4934, database is CAplus and MEDLINE.

The trifluoromethylation of benzoic acids with TMSCF₃ was achieved through nucleophilic substitution with the use of anhydrides as an in situ activating reagent. Under the reaction conditions, a wide range of carboxylic acids including the bioactive ones worked well, thus providing a facile and efficient method for preparing aryl trifluoromethyl ketones from the readily available starting materials.

Organic Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Product Details of C13H16O2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Yace Mi published the artcileThe Roles Played by DMF in the Structure Formation of Epoxy-Based Porous Monolith, COA of Formula: C13H26N2, the publication is Polymer Science, Series B: Polymer Chemistry (2020), 62(5), 465-472, database is CAplus.

Abstract: Epoxy-based porous monoliths are prepared by chem. induced phase separation The roles played by N,N-dimethylformamide (DMF) in both curing and phase separation kinetics are studied in detail. It is found that the addition of DMF not only changes the speed of phase separation, but the way. Meanwhile, the occurrence of secondary phase separation is partly inhibited, which is in favor of the formation of skeletal network structure. In addition, the schematic pseudo phase diagrams were deduced, which are of great significance to understand the roles played by DMF for the targeted control of materials structure. The results show that by the addition of DMF, the phase diagram moves to the lower right, which means more porogen is needed to obtain skeletal network structure. The spinodal line moves toward the binodal line and the internal space of spinodal line is enlarged. Therefore, it becomes more available to obtain skeletal network structure.

Polymer Science, Series B: Polymer Chemistry published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C15H10O2, COA of Formula: C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Duan, Ke published the artcileContacts transition induced stiffening mechanism in CNT-network/epoxy composites, Computed Properties of 1761-71-3, the publication is Carbon (2021), 767-774, database is CAplus.

The origin of abnormal enhancement in the elastic modulus of CNT-network/polymer composites is a fundamental but unresolved issue. Through mesoscale mol. dynamics simulations, we revealed that contrary to the conventional beliefs, it is not the improved interface load transfer ability among well contacted bundles but a contacts transition induced stiffening mechanism among weak contacted bundles that triggers such an abnormal enhancement. This is because the presence of epoxy mols. into the network pores leads to a remarkable densification effect on the composites thickness, improving the strength of those weak contact junctions between neighboring CNT layers and turning them into load-bearing contact junctions. Such a contacts transition phenomenon significantly increases the number of contact nodes and therefore load transfer paths within CNT-network, enabling more than one order of magnitude improvement in the composite modulus. Specifically, the proposed stiffening mechanism is correlated to the content of introduced epoxy, offering an effective route for tailoring the mech. properties of derived composites.

Carbon published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Computed Properties of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Shao, Zhuzhou published the artcileBioorthogonal release of sulfonamides and mutually orthogonal liberation of two drugs, Application of Dbco-acid, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(100), 14089-14092, database is CAplus and MEDLINE.

Sulfonamide derivatives have been used in pharmaceutics for decades. Here we report a new approach to release sulfonamides efficiently using a bioorthogonal reaction of sulfonyl sydnonimines and dibenzoazacyclooctyne (DIBAC). The second-order rate constant of the cycloaddition reaction can be up to 0.62 M^-1s^-1, and the reactants are highly stable under physiol. conditions. Most significantly, we also discovered the mutual orthogonality between the sydnonimine-DIBAC and benzonorbornadiene-tetrazine cycloaddition pairs, which can be used for selective and simultaneous liberation of sulfonamide and primary amine drugs.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C11H17BO3S, Application of Dbco-acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Wang, Wentao published the artcileMultifunctional and High Affinity Polymer Ligand that Provides Bio-Orthogonal Coating of Quantum Dots, Synthetic Route of 1353016-70-2, the publication is Bioconjugate Chemistry (2016), 27(9), 2024-2036, database is CAplus and MEDLINE.

The authors detail the design of hydrophilic metal-coordinating ligands and their use for the effective coating of luminescent quantum dots. The ligand design exploits the specific, reagent-free nucleophilic addition reaction of amine-modified mols. toward maleic anhydride to introduce several lipoic acid metal-anchors, hydrophilic zwitterion moieties and specific reactive groups along a poly(isobutylene-alt-maleic anhydride) (PIMA) chain. Tunable reactive groups tested in this study include azide, biotin, carboxyl, and amine. Cap exchange with these multi-lipoic acid ligands via a photochem. ligation strategy yields homogeneous QD dispersions that are colloidally stable over several biol.-relevant conditions and for extended periods of time. The zwitterionic coating yields compact nanoparticle size and imparts non-sticky surface properties onto the QDs, preventing protein absorption. The introduction of a controllable number of reactive groups allows conjugation of the QDs to biomols. via bio-orthogonal coupling chemistries including: (1) attachment of the neurotransmitter dopamine to QDs via amine-isothiocyanate reaction to produce a platform capable of probing interactions with cysteine in proteins, based on charge transfer interactions; (2) self-assembly of biotinylated QDs with streptavidin-dye; (3) ligation of azide-functionalized QDs to cyclooctyne-modified transferrin via copper-free click chem. for intracellular delivery. This ligand design strategy can be used to prepare an array of metal-coordinating ligands adapted for coating other inorganic nanoparticles, including magnetic and plasmonic nanomaterials.

Bioconjugate Chemistry published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C8H11BO2, Synthetic Route of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Wang, Qin published the artcileInhibitory effects of benzoic acid derivatives on polyphenol oxidase from Pieris rapae, COA of Formula: C13H16O2, the publication is Xiamen Daxue Xuebao, Ziran Kexueban (2006), 45(3), 428-431, database is CAplus.

The title polyphenol oxidase was extracted from the 5th instar of Pieris rapae in present paper. The effects of benzoic acid derivatives on the catalysis activity of polyphenol oxidase for the oxidation of L-dopa were investigated, including terephthalaldhydic acid (a), p-methoxybenzoic acid (b), p-isopropylbenzoic acid (c), p-cyclohexylbenzoic acid (d), p-chlorobenzoic acid (e), p-fluorobenzoic acid (f), and p-bromobenzoic acid (g). The IC₅₀ of a, b, c, d and f were 10.63, 12.22, 1.75, 2.10 and 6.64 mmol/L, resp., while e and g without obvious inhibitory effects. The study results of inhibitory kinetics showed that a, c and f were competitive inhibitors, while b and d were noncompetitive ones. Their inhibition constants were determined and compared. Obviously, the inhibitory effects of c and d were higher than the other compounds, so they might have the bright prospect in the future as the insecticide.

Xiamen Daxue Xuebao, Ziran Kexueban published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C11H10O, COA of Formula: C13H16O2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Tian, Yazhou published the artcileA resveratrol-based epoxy resin with ultrahigh T_g and good processability, Quality Control of 1761-71-3, the publication is European Polymer Journal (2021), 110282, database is CAplus.

Preparing and designing an epoxy system with ultrahigh glass transition temperature (T_g > 300°C) is always a big challenge, which restrict its applications in some cutting-edge areas such as aerospace engineering and elec. electronics. Herein, a biomass-based epoxy resin (REEP) was prepared from resveratrol, and then curing behavior, thermal-mech. properties, mech. performance, thermal stability, dielec. properties and optical properties of REEP/HDDM, REEP/DGEBA/HDDM and DGEBA/HDDM were resp. studied systematically. Results suggested that the T_g of REEP/HDDM was above 320°C, higher than those of most reported epoxy systems, both derived from biomass-based and petroleum-based materials. Moreover, the tensile strength of REEP/HDDM, REEP/DGEBA/HDDM and DGEBA/HDDM were 77.8 MPa, 70.8 MPa and 63.6 MPa, resp., and the T_d5% of REEP/HDDM, REEP/DGEBA/HDDM and DGEBA/HDDM were 319.9°C, 335.1°C and 348.1°C, resp., indicating excellent mech. performance and thermal stability of the cured epoxy system. Interestingly, the REEP/HDDM exhibited outstanding blocking properties in the range of 220-400 nm (UV-light) and low flammability with compact and continuous char residues. In short, REEP, with a well-defined chem. structure, has a stiffness conjugated stilbene structure to prevent the mol. from motioning in the crosslinked network structure and three epoxy groups, thereby increasing the crosslinked d. dramatically, which endows REEP/HDDM network with outstanding comprehensive properties.

European Polymer Journal published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C6H13BO3, Quality Control of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Boisaubert, Pierre published the artcilePolyurethane coatings from formulations with low isocyanate content using a transurethane polycondensation route, Related Products of quinuclidine, the publication is Polymer (2022), 124522, database is CAplus.

A strategy aiming to decrease the amount of isocyanate in the PU industries without changing their current facilities is proposed. Hydroxyl terminated non-isocyanate polyurethane (NIPU) oligomers (H-Ol) with controlled mol. weights and chem. structures have been prepared as precursors. They were prepared by transurethane polycondensation between bis(methylcarbamate) (BMC), hydroxyterminated poly(tetramethyleneoxide) (PTMO) and butanediol at several molar ratios. H-Ol were then reacted with a polyisocyanurate as crosslinking agent to afford several partially NIPU coatings. Polyurethanes based on the PTMO polyols and the polyisocyanurate were also prepared as controls to highlight the importance of the urethane function in the H-Ol. The influence of the chem. structures on the thermal and mech. properties of the final coatings has been investigated. The prepared coatings displayed thermal stabilities above 200°C, Young modulus ranging from 3 to 64 MPa, tensile strength values from 0.9 to 17 MPa and elongation at break varying from 25 to 530%. H-Ol with the highest urethane content gave a coating with the best adhesion properties on a metal surface. All the obtained properties were within the characteristic range of two com. PU reference coatings.

Polymer published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Boisaubert, Pierre published the artcilePhoto-crosslinked Non-Isocyanate Polyurethane Acrylate (NIPUA) coatings through a transurethane polycondensation approach, Quality Control of 1761-71-3, the publication is Polymer (2020), 122855, database is CAplus.

A transurethane polycondensation pathway was used to produce acrylate terminated non-isocyanate polyurethane (NIPUA) oligomers (A-Ol) with controlled mol. weights and chem. structures. These compounds were then photocrosslinked under UV radiations to afford several NIPU acrylate coatings. The influence of the content in urethane functions as well as the chem. structures on the thermal and mech. properties of the final coatings was demonstrated. The obtained coatings exhibited thermal stabilities above 255°C, Young modulus ranging from 2.6 to 9.2 MPa, tensile strength up to 11.8 MPa and elongation at break varying from 20 to 520%.

Polymer published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Quality Control of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider