Category: quinuclidine

Reichmuth, Andreas M. published the artcileInvestigating Complex Samples with Molograms of Low-Affinity Binders, Recommanded Product: Dbco-acid, the publication is ACS Sensors (2021), 6(3), 1067-1076, database is CAplus and MEDLINE.

In vitro diagnostics relies on the quantification of minute amounts of a specific biomol., called biomarker, from a biol. sample. The majority of clin. relevant biomarkers for conditions beyond infectious diseases are detected by means of binding assays, where target biomarkers bind to a solid phase and are detected by biochem. or phys. means. Nonspecifically bound biomols., the main source of variation in such assays, need to be washed away in a laborious process, restricting the development of widespread point-of-care diagnostics. Here, we show that a diffractometric assay provides a new, label-free possibility to investigate complex samples, such as blood plasma. A coherently arranged sub-micron pattern, i.e., a peptide mologram, is created to demonstrate the insensitivity of this diffractometric assay to the unwanted masking effect of nonspecific interactions. In addition, using an array of low-affinity binders, we also demonstrate the feasibility of mol. profiling of blood plasma in real time and show that individual patients can be differentiated based on the binding kinetics of circulating proteins.

ACS Sensors published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Recommanded Product: Dbco-acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Fredenhagen, Andreas published the artcileEvaluation of the optimization space for atmospheric pressure photoionization (APPI) in comparison with APCI, COA of Formula: C13H16O2, the publication is Journal of Mass Spectrometry (2014), 49(8), 727-736, database is CAplus and MEDLINE.

The usefulness of atm. pressure photoionization (APPI) is difficult to evaluate for unknowns due to the fragmented literature. Specifically, the variation of dopants with a wide set of compounds or the use of APPI in the neg. mode have rarely been explored. Thirty compounds were selected that were not suitable for ESI with a wide variety of functional groups and investigated with atm. pressure chem. ionization (APCI) and APPI in the pos. and neg. ion modes. The influence of the mobile phase (eluents containing acetonitrile or methanol) and – for APPI – four different dopants (acetone, chlorobenzene, toluene, and toluene/anisole) were explored. Stepwise variation of the organic mobile phase allowed to elucidate the ionization mechanism. Atm. pressure photoionization was especially useful for compounds, where the M^•+ and not the [M + H]⁺ was formed. The dopants chlorobenzene and anisole promoted the formation of mol. ions M^•+ for about half of the compounds, and its formation was also pos. influenced by the use of mobile phases containing methanol. In the neg. ion mode, APPI offered no advantage toward APCI. Best results were generally achieved with the dopant chlorobenzene, establishing that this dopant is suitable for a wide set of compounds For one quarter of the compounds, significantly better results were achieved with mobile phases containing methanol for both APPI and APCI than those with acetonitrile, but only in the pos. mode. With either of the methods – APPI or APCI – about 10% of the compounds were not detected. Strategies to get results quickly with difficult unknowns will be discussed.

Journal of Mass Spectrometry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, COA of Formula: C13H16O2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Sekhar, B. V. V. N. Chandra published the artcileSynthesis of Montelukast sodium via an ester intermediate; synthesis and characterization of impurities, HPLC of Formula: 162515-68-6, the publication is International Journal of Pharma and Bio Sciences (2011), 2(3), 399-407, database is CAplus.

Novel synthetic approaches for the synthesis of a leukotriene receptor antagonist, Montelukast sodium [i.e., 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt] were designed. Reduction of the starting material [methyl (E)-2-[3-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoate] provided an alc. compound and the formation of montelukast dicyclohexylamine was accomplished by subsequent introduction of (mercaptomethyl)cyclopropaneacetic acid. The current study also deals with the synthesis and characterization of reaction products which are classified as impurities of Montelukast sodium. Impurities and byproducts reported here included a sulfine (sulfoxide), (S)-montelukast (acid), etc.

International Journal of Pharma and Bio Sciences published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C10H16Br3N, HPLC of Formula: 162515-68-6.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Rumyantseva, Yu. B. published the artcileIntensification of oxidation of cyclohexyltoluene to hydroperoxide, Computed Properties of 20029-52-1, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (2011), 54(10), 102-104, database is CAplus.

Liquid phase oxidation of cyclohexyltoluene to hydroperoxide was studied in the presence of initiator – isopropylbenzene hydroperoxide and nitrogen-containing catalysts. The oxidation rate of cyclohexyltoluene increases 2.5-3 times at the presence of N-hydroxyphthalimide at 110-140°. The hydrocarbon conversion is up to 28-30% and the selectivity of cyclohexyltoluene hydroperoxide I formation is 93-95%.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Computed Properties of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Hu, Fengshuo published the artcileEpoxidized soybean oil modified using fatty acids as tougheners for thermosetting epoxy resins: Part 2-Effect of curing agent and epoxy molecular weight, Safety of 4,4-Diaminodicyclohexyl methane, the publication is Journal of Applied Polymer Science (2021), 138(24), 50579, database is CAplus.

A series of bio-rubber (BR) tougheners for thermosetting epoxy resins was prepared by grafting renewable fatty acids with different chain lengths onto epoxidized soybean oil at varying molar ratios. BR-toughened samples were prepared by blending BRs with diglycidyl ether of bisphenol A resins, Epon 828 and Epon 1001F, at different weight fractions and stoichiometrically cured using an amine curing agent, 4, 4′-methylene biscyclohexanamine (PACM). Fracture toughness properties of the unmodified and BR toughened polymer samples-including critical strain energy release rate (G_Ic), and critical stress intensity factor (K_Ic)-were measured to investigate the toughening effect of prepared BRs. It was found that the degree of phase separation and toughening were more controllable relative to similar polymers cured using the aromatic curing agent Epikure W, and the use of higher mol. epoxy resins produces a synergistic effect increasing the toughness much more than similar polymers made with lower mol. weight epoxy resins. Average BR domain sizes ranging from 200 to 900 nm were observed, and formulations with G_Ic, values K_Ic as high as 1.0 kJ/m² and 1.4 MPa m^1/2 were attained resp. for epoxy systems with T_g greater than 130°C.

Journal of Applied Polymer Science published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Safety of 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Liu, Yu published the artcileGO-CNTs hybrids reinforced epoxy composites with porous structure as microwave absorbers, Related Products of quinuclidine, the publication is Composites Science and Technology (2020), 108450, database is CAplus.

Foam structures with epoxy as the matrix and both carbon nanotubes (CNTs) and their hybrids with graphene oxide (GO-CNTs) as absorbers were fabricated, and their microwave absorbing and electromagnetic properties were investigated in the frequency range of 1-18 GHz. The fillers and bubbles were uniformly distributed in the composites. The complex permittivity and elec. conductivity of the composites increased as the fillers’ content increasing. The best performance of the reflection loss (RL) can be obtained for a foam structure with 0.5 wt% GO-CNTs, which had a RL peak value of -20dB with a -10 dB range of 5.3 GHz (10.8-16.1 GHz). Multi-layered structures were also discussed in this work, a RL peak value of -40dB with a -10dB range of 7.1 GHz (9.9-17 GHz) had been obtained by combining two foam structures, which are 2 mm thick 0.5 wt% GO-CNTs/epoxy and 1 mm thick 2.0 wt% GO-CNTs/epoxy. Furthermore, the -10dB range can reach 11.5 GHz (6.5-18 GHz) when combining 2.6 mm thick 0.5 wt% GO-CNTs/epoxy and 1.3 mm thick 2.0 wt% GO-CNTs/epoxy.

Composites Science and Technology published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Kang, Houng published the artcileEnantioselective Vanadium-Catalyzed Oxidative Coupling: Development and Mechanistic Insights, Formula: C28H41N2P, the publication is Journal of Organic Chemistry (2018), 83(23), 14362-14384, database is CAplus and MEDLINE.

The evolution of a more reactive chiral vanadium catalyst for enantioselective oxidative coupling of phenols is reported, ultimately resulting in a simple monomeric vanadium species combined with a Bronsted or Lewis acid additive. The resultant vanadium complex is found to effect the asym. oxidative ortho-ortho coupling of simple phenols and 2-hydroxycarbazoles with good to excellent levels of enantioselectivity. Exptl. and quantum mech. studies of the mechanism indicate that the additives aggregate the vanadium monomers. In addition, a singlet to triplet crossover is implicated prior to carbon-carbon bond formation. The two lowest energy diastereomeric transition states leading to the enantiomeric products differ substantially with the path to the minor enantiomer involving greater torsional strain between the two phenol moieties.

Journal of Organic Chemistry published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Formula: C28H41N2P.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Heilbron, I. M. published the artcileUnion of aryl nuclei. II. Chloro-, bromo- and nitrofluorenones, Category: quinuclidine, the publication is Journal of the Chemical Society (1938), 113-16, database is CAplus.

By means of the Gomberg reaction, diazotized Me anthranilate (or a derivative) and a neutral aromatic liquid being used, nuclear-substituted biphenyl-2-carboxylic acids become readily available, from which the corresponding substituted fluorenones may be obtained quant. on ring closure. Me 4-chloroanthranilate and C₆H₆ thus give 25% of the Me ester, b₂₀ 180-90°, of 5-chlorodiphenyl-2-carboxylic acid (I), m. 152°; ring closure with H₂SO₄ gives 3-chlorofluorenone (II), yellow, m. 157°; 4-Cl isomer of I, m. 157°; 2-Cl isomer of II, m. 123°; 5-Br analog of I, m. 172°; 3-Br analog of II, m. 161°; the 4-isomers, m. 164°, and 150°, were likewise prepared 4-NO₂ analog of I, m. 173°; ring closure gives the 4-NO₂ analog of II, m. 219°. PhCl and PhBr give mixtures of the 2′- and 4′-Cl and Br derivatives, the separation of which was only partly successful. p-ClC₆H₄N₂Cl and PhMe give 4′-chloro-2-methylbiphenyl, b. 288-90°; oxidation gives 4′-chloro-biphenyl-2-carboxylic acid, m. 161°; ring closure gives the 2-Cl isomer of II.

Journal of the Chemical Society published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Category: quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

David, Tomas published the artcileImproved Conjugation, 64-Cu Radiolabeling, in Vivo Stability, and Imaging Using Nonprotected Bifunctional Macrocyclic Ligands: Bis(Phosphinate) Cyclam (BPC) Chelators, Application In Synthesis of 1353016-70-2, the publication is Journal of Medicinal Chemistry (2018), 61(19), 8774-8796, database is CAplus and MEDLINE.

Bifunctional derivatives of Bis(Phosphinate)-bearing Cyclam (BPC) chelators bearing carboxylate, amine, isothiocyanate, azide or cyclooctyne in BP-side chain were synthesized. Conjugations required no protection of phosphinate or ring secondary amine groups. The ring amines were not reactive (proton protected) at pH < ∼8. For isothiocyanate coupling, oligopeptide N-terminal α-amines were more suitable than alkyl amines, e.g. Lys ω-amine (pKa ∼7.5-8.5 and ∼10-11, resp.) due to lower basicity. The Cu-64 labeling was efficient at room temperature (specific activity ∼100 GBq/μmol; 25°C, pH 6.2, ∼100 ligand equivalent, 10 min). A representative Cu-64-BPC was tested in-vivo showing fast clearance and no non-specific radioactivity deposition. The monoclonal anti-PSCA antibody 7F5 conjugates with thiocyanate BPC derivative or NODAGA were radiolabeled and studied in PC-3-PSCA tumor bearing mice by PET. The radiolabeled BPC conjugate was accumulated in the prostate tumor with low off-target uptake, unlike Cu-64-labeled NODAGA-antibody conjugate. The BPC chelators have a great potential for theranostic applications of Cu-64/Cu-67 matched pair.

Journal of Medicinal Chemistry published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Application In Synthesis of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Wezeman, Tim published the artcileSynthesis of Non-Symmetrical and Atropisomeric Dibenzo[1,3]diazepines: Pd/CPhos-Catalyzed Direct Arylation of Bis-Aryl Aminals, Related Products of quinuclidine, the publication is Australian Journal of Chemistry (2015), 68(12), 1859-1865, database is CAplus.

Pd/CPhos-catalysis provides direct arylation/cyclization of methylene-linked bis[anilines] to dibenzo[1,3]diazepines which are both non-(C2)-sym. and axially chiral. Synthesis of the direct arylation substrates commences with substitution of (N-acyl)anilines to methylene Me sulfide derivatives, followed by halogenation/de-thiomethylation to N-(chloromethyl)anilines. These are substituted with a second aniline derivative, allowing modular preparation of (ortho-halo)aryl-aminal-linked arenes. The C-H functionalizing direct arylation conditions were adapted from Fagnou and others: substrates and potassium carbonate were heated in dimethylacetamide in the presence of palladium acetate and an electron-rich and sterically hindered biarylphosphine ligand, here CPhos. These conditions delivered the C1-(a)sym. dibenzo[1,3]diazepine targets, which, due to torsion around the axis of the newly formed biaryl bond, are also intrinsically atropisomeric. The axially twisted scaffold is known to impart special properties to ligands/catalysts when the products are further converted into the corresponding seven-membered ring-containing N-heterocyclic carbenes. Under optimized conditions the synthesis of the target compounds was achieved using 2′-(dicyclohexylphosphino)-N²,N²,N⁶,N⁶-tetramethyl[1,1′-biphenyl]-2,6-diamine (i.e., CPhos) and palladium acetate as ligand and catalyst combination. Key intermediates included N,N’-(methylene)-N,N’-bis(phenyl)acetamide derivatives (i.e., the above-mentioned aminals).

Australian Journal of Chemistry published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C5H12O2, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider