Category: quinuclidine

Weis, Erik published the artcileIr^III-Catalyzed Selective ortho-Monoiodination of Benzoic Acids with Unbiased C-H Bonds, Safety of 4-Cyclohexylbenzoic acid, the publication is Chemistry – A European Journal (2020), 26(45), 10185-10190, database is CAplus and MEDLINE.

An iridium-catalyzed selective ortho-monoiodination of benzoic acids with two equivalent C-H bonds was presented. A wide range of electron-rich and electron-poor substrates underwent the reaction under mild conditions, with >20:1 mono/di selectivity. Importantly, the C-H iodination occurred selectively ortho to the carboxylic acid moiety in substrates bearing competing coordinating directing groups. The reaction was performed at room temperature and no inert atm. or exclusion of moisture was required. Mechanistic investigations revealed a substrate-dependent reversible C-H activation/protodemetalation step, a substrate-dependent turnover-limiting step and the crucial role of the AgI additive in the deactivation of the iodination product towards further reaction.

Chemistry – A European Journal published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C18H28B2O4, Safety of 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Sakakibara, Keita published the artcilePerformance improvement of epoxy polymer monolith films by reinforcing with cellulose fibers, Product Details of C13H26N2, the publication is Nettowaku Porima Ronbunshu (2020), 41(6), 245-251, database is CAplus.

In this article, we demonstrate the preparation of epoxy polymer monolith composite films with cellulose fibers for improving the mech. property, where the monolith is a porous material with a co-continuous skeletal structure. The preparation includes lamination process or simple hanging process for cellulose-fiber nonwoven sheet impregnated with monolith precursor mixtures, followed by polymerization induced phase separation based on spinodal decomposition The resulting monolith composite films were surface skin-less, exhibiting the pore sizes from 200 nm to 1.5μm. The tensile Young’s modulus and strength were higher than those of the neat monolith film and the previously-reported cellulose nanofiber-reinforced monolith films. The ionic conductivity of the composite films with lithium-ion electrolyte was comparable to that of com.-available polyolefin porous membranes. The epoxy polymer monolith composite film is expected to have a great potential as a promising separator for next-generation lithium ion batteries by taking advantage of its high heat resistance and winding channel structure.

Nettowaku Porima Ronbunshu published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Product Details of C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Black, Jacob W. published the artcileAn Optical Tweezers Platform for Single Molecule Force Spectroscopy in Organic Solvents, Application of Dbco-acid, the publication is Nano Letters (2017), 17(11), 6598-6605, database is CAplus and MEDLINE.

Observation at the single mol. level was a revolutionary tool for mol. biophysics and materials science, but single mol. studies of solution-phase chem. are less widespread. The authors develop an exptl. platform for solution-phase single mol. force spectroscopy in organic solvents. This optical-tweezer-based platform was designed for broad chem. applicability and uses optically trapped core-shell microspheres, synthetic polymer tethers, and click chem. linkages formed in situ. Stable optical trapping of the core-shell microspheres in 10 different solvents was observed, as was single mol. link formation in 4 different solvents. These experiments demonstrate how to use optical tweezers for single mol. force application in the study of solution-phase chem.

Nano Letters published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Application of Dbco-acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Krasnikov, S. V. published the artcileSynthesis of 1,2-dibromoalkyl-substituted carboxylic acids of aromatic series, Recommanded Product: 4-Cyclohexylbenzoic acid, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (2010), 53(9), 120-121, database is CAplus.

The 4-(1,2-dibromoisopropyl)- and 4-(1,2-dibromocyclohexyl)benzoic acids were synthesized by homolytic bromination of 4-isopropyl- and 4-cyclohexylbenzoic acids, resp. The trans-configuration of 4-(1,2-dibromocyclohexyl)benzoic acid was confirmed by both ¹H NMR spectroscopy and independent synthesis from 4-(1-cyclohexenyl)benzoic acid.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Recommanded Product: 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Krasnikov, S. V. published the artcileSynthesis of 1,2-dibromoalkyl-substituted aromatic carboxylic acids, Application of 4-Cyclohexylbenzoic acid, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (2011), 54(5), 131-132, database is CAplus.

4-(1,2-Dibromoisopropyl)benzoic acid and 4-(1,2-dibromocyclohexyl)benzoic acid (I) were synthesized using the reaction of free-radical bromination. The trans-conformation of acid I was confirmed by ¹H NMR spectroscopy and counter synthesis.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Application of 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Meichsner, Eric published the artcileStrain-promoted azide-alkyne cycloaddition polymerization as a route toward tailored functional polymers, Safety of Dbco-acid, the publication is Journal of Polymer Science (Hoboken, NJ, United States) (2021), 59(1), 29-33, database is CAplus.

The preparation of polymers under mild conditions, using highly efficient reactions, allows the incorporation of new, functional monomer units. Here, we explore the use of strain-promoted azide-alkyne cycloaddition (SPAAC) as a polymerization tool. We show that a polymer library with diverse thermal and stimulus-responsive properties can be rapidly prepared in minutes. This polymerization proceeds without heating or the addition of catalyst, which enables the preservation of sensitive moieties, such as stimulus-responsive spiropyran structures. Solid- and solution-state stimulus-responsiveness from these sensitive groups are demonstrated within the SPAAC-polymerized products.

Journal of Polymer Science (Hoboken, NJ, United States) published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Safety of Dbco-acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Blersch, Josephine published the artcileA light-triggerable formulation to control the stability of pro-angiogenic transcription factor hypoxia inducible factor-1α (HIF-1α), Application of 4,4-Diaminodicyclohexyl methane, the publication is Nanoscale (2020), 12(18), 9935-9942, database is CAplus and MEDLINE.

The control of vascular remodeling mediated by transcription factor HIF-1a is critical in the treatment of several diseases including cancer, retinopathies, chronic wounds, and ischemic heart disease, among others. Gene silencing using a small interfering RNA (siRNA) is a promising therapeutic strategy to regulate HIF-1a; however, the delivery systems developed so far have limited endothelial targeting and efficiency. Herein, we have synthesized a light-triggerable polymeric nanoparticle (NP) library composed of 110 formulations which showed variable morphol., charge and disassembly rates after UV exposure. More than 35% of the formulations of the library were more efficient in gene knockdown than the siRNA delivered by a com. transfection agent (lipofectamine RNAiMAX). The most efficient siRNA delivery formulations were tested against different cell types to identify one with preferential targeting to endothelial cells. Using a two-step methodol., we have identified a formulation that shows exquisite targeting to endothelial cells and is able to deliver more efficiently the siRNA that modulates HIF-1a than com. transfection agents. Overall, the strategy reported here increases the specificity for tissue regulation and the efficiency for the intracellular delivery of siRNAs.

Nanoscale published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Application of 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Fornwald, Ryan M. published the artcileInfluence of Catalyst Structure and Reaction Conditions on anti- versus syn-Aminopalladation Pathways in Pd-Catalyzed Alkene Carboamination Reactions of N-Allylsulfamides, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, the publication is Chemistry – A European Journal (2014), 20(28), 8782-8790, database is CAplus and MEDLINE.

The Pd-catalyzed coupling of N-allylsulfamides with aryl and alkenyl triflates to afford cyclic sulfamide products is described. In contrast to other known Pd-catalyzed alkene carboamination reactions, these transformations may be selectively induced to occur by way of either anti- or syn-aminopalladation mechanistic pathways by modifying the catalyst structure and reaction conditions.

Chemistry – A European Journal published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Liang, Naiqiang published the artcileColorless Copolyimide Films Exhibiting Large Stokes-Shifted Photoluminescence Applicable for Spectral Conversion, Application of 4,4-Diaminodicyclohexyl methane, the publication is ACS Applied Polymer Materials (2021), 3(8), 3911-3921, database is CAplus.

A series of semi-aliphatic polyimide (PI) copolymers (CoPIs) were prepared through the copolymerization of two dianhydrides, 1-hydroxy pyromellitic dianhydride (PHDA) and 4,4′-oxydiphthalic anhydride (ODPA), with 4,4′-diaminodicyclohexylmethane, in which the PHDA molar ratio was controlled at less than 5% to suppress aggregate formation in a solid state. Upon increasing the molar ratio of the PHDA unit, the fluorescence color of the CoPI films continuously changed from pink to yellow through an orange color owing to the enhanced emission from the anionic form of the PHDA unit, and the efficiency of the energy transfer from the locally excited S₁ state to the anionic state simultaneously increased. Moreover, the CoPI film with a PHDA content of 3 mol % that formed on a silica substrate was colorless and transparent and showed bright orange fluorescence. However, this CoPI film formed on a soda-lime-silica (soda) glass substrate showed a pale-yellow color as well as yellowish fluorescence originating from the anionic form owing to the high basicity of the soda glass. To suppress the absorption and emission from the anions, a small amount of sulfuric acid was doped into the CoPI film, and a colorless and transparent film exhibiting large Stokes-shifted orange fluorescence was successfully obtained on the soda glass substrate. The wavelength-converting spectrum of the CoPI demonstrated that UV irradiation in solar light was efficiently absorbed, and its energy was converted into visible light between 500 and 700 nm with a quantum efficiency of 20%. These CoPI films exhibiting large Stokes-shifted ESIPT fluorescence on both silica and the soda glass substrates are promising materials for solar spectral conversion applications.

ACS Applied Polymer Materials published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Application of 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Dufresne, Claude published the artcileSynthesis of Montelukast (MK-0476) Metabolic Oxidation Products, Related Products of quinuclidine, the publication is Journal of Organic Chemistry (1996), 61(24), 8518-8525, database is CAplus.

Chem. synthesis of six oxidized derivatives of MK-0476 (Montelukast, L-706631), which have been key tools in the identification of its metabolites is reported. Three diastereoisomeric pairs I (R₁ = H, OH; R₂ = H, OH; R₃ = Me, CH₂OH) of potential oxidative metabolites of MK-0476, starting from the (S)-hydroxy ester II in 10 and five steps, and starting from MK-0476 itself in one step have been prepared In one case the key benzylic hydroxyl was introduced by a bromination and saponification reaction sequence. In another case, the key step was the addition of a hydroxymethyl carbanion equivalent on ketone. The two sulfoxides were prepared by a direct oxidation of MK-0476 with m-chloroperbenzoic acid.

Journal of Organic Chemistry published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C6H10O2S, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider