Category: quinuclidine

An article , which mentions 123536-14-1, molecular formula is C7H16Cl2N2. The compound – (R)-3-Aminoquinuclidine dihydrochloride played an important role in people’s production and life., COA of Formula: C7H16Cl2N2

[…] aromatic system amide derivative and its preparation and use (by machine translation)

The invention discloses a […] aromatic system amide derivatives, its general formula (I) is shown, wherein the R, W1 , W2 , W3 , W4 See the specification. In addition, the invention also discloses a method for preparation of the above compounds, pharmaceutical composition. The invention relates to a compound has good alpha 7 receptor binding activity, higher selectivity and high levels of agonist effect. (by machine translation)

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 123536-14-1, help many people in the next few years.COA of Formula: C7H16Cl2N2

Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H135N | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 827-61-2, such as the rate of change in the concentration of reactants or products with time.In a article, authors is Aggarwal, Varinder K., mentioned the application of 827-61-2, Name is Quinuclidin-3-yl acetate, molecular formula is C9H15NO2

Correlation between pKa and reactivity of quinuclidine-based catalysts in the Baylis-Hillman reaction: Discovery of quinuclidine as optimum catalyst leading to substantial enhancement of scope

The reactivity of a variety of quinuclidine-based catalysts in the Baylis-Hillman reaction has been examined, and a straightforward correlation between the basicity of the base and reactivity has been established, without exception. The following order of reactivity was established with pKa’s of the conjugate acids (measured in water) given in parentheses: quinuclidine (11.3), 3-hydroxyquinuclidine (9.9), DABCO (8.7), 3-acetoxyquinuclidine (9.3), 3-chloroquinuclidine (8.9), and quinuclidinone (7.2). The higher than expected reactivity of DABCO, based on its pKa, was analyzed by comparing the relative basicity of DABCO and 3-acetoxyquinuclidine in DMSO. It was found that in aprotic solvent, DABCO was 0.6 pKa units more basic than 3-acetoxyquinuclidine, thus establishing a direct link between pKa of the amine and its reactivity. In contrast to previous literature work that reported the contrary, quinuclidine, which has the highest pKa, was found to be the most active catalyst. The reaction profile with quinuclidine showed significant autocatalysis, which suggested that the presence of proton donors might further enhance rates. Thus, a series of additives bearing polar X-H bonds were investigated and it was found that methanol, triethanolamine, formamide, and water all provided additional acceleration. Methanol was found to be optimum, and the powerful combination of quinuclidine with methanol was tested with a host of aldehydes and Michael acceptors. Not only were the reactions more efficient and faster than previously reported, but now new substrates that were previously unreactive could be employed. Notable examples include the use of acetylenic aldehydes and the employment of vinyl sulfones, acrylamides, delta-lactones, and even alpha,beta-unsaturated esters bearing a beta-substituent.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 827-61-2, help many people in the next few years.Product Details of 827-61-2

Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H45N | ChemSpider

Synthetic Route of 5291-32-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.5291-32-7, Name is APR-246, molecular formula is C10H17NO3. In a Patent£¬once mentioned of 5291-32-7

2-SULFONYLPYRIMIDINES

The invention relates to 2-sulfonylpyrimidine compounds and salts and solvates thereof for use in the treatment of a proliferative disease such as cancers. The 2- sulfonyl-primidine compounds may be administered, either simultaneously or sequentially, with one or more pharmacologically active compounds and salts and solvates thereof such as an inhibitor of glutamate cysteine ligase. The 2- sulfonylpyrimidine compound may be represented by formula (I): (I) wherein: R1 is selected from C1-6 alkyl, C6-12 aryl, C7-18 aralkyl, 6- to 15-membered heteroaralkyl and 6- to 12-membered heterocyclylalkyl wherein each of these groups are optionally substituted with from one to three optional substituents; R2 is selected from CF3, O-C(O)-R6, C(O)R7, C(O)NHR7 and NHC(O)R7; R3 is selected from H, F, CI, Br, I, OH, C1-6 alkyl, OC1-6 alkyl, CH2F, CHF2, CF3, CN, NO2, CO2R8, C(O)NHR10, NHC(O)R10, (CH2)z-NR8R9 and (CH2)z-NH-C(=NH)-NH2; R4 is selected from H, C1-6 alkyl and CH2R11; R5 is selected from C1-6 alkyl; R6 is selected from H and C1-6 alkyl; R7 is selected from 5 to 9-membered heteroaryl groups, and phenyl wherein these groups are optionally substituted with from one to three optional substituents; and wherein the heteroaryl group is attached to the rest of compound of formula (I) by a carbon ring atom; R8 and R9 are independently selected from H, C1-6 alkyl and benzyl; R10 is selected from 5- to 9-membered heteroaryl groups, 5- and 6-membered heterocyclyl, and phenyl wherein these groups are optionally substituted with from one to three optional substituents; R11 is phenyl optionally substituted; and z is selected from an integer selected from o to 6.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Synthetic Route of 5291-32-7, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about Synthetic Route of 5291-32-7

Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H165N | ChemSpider

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of Quinuclidin-3-yl acetate, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 827-61-2, Name is Quinuclidin-3-yl acetate, molecular formula is C9H15NO2

Design, Synthesis, and Neurochemical Evaluation of 5-(3-Alkyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 Muscarinic Receptor Agonists

A series of 5-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines (7a-h) was synthesized for biological evaluation as selective agonists for M1 receptors coupled to phosphoinositide (PI) metabolism in the central nervous system.Each ligand bound with high affinity to muscarinic receptors from rat brain as measured by inhibition of <3H>-(R)-quinuclidinyl benzilate (<3H>-(R)-QNB) binding. 5-(3-Methyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine trifluoroacetate (CDD-0098-J; 7a)displayed high affinity (IC50 = 2.7 +/- 0.69 muM) and efficacy at muscarinic receptors coupled to PI metabolism in the rat cortex and hippocampus .Increasing the length of the alkyl substituent increased affinity for muscarinic receptors yet decreased activity in PI turnover assays.The hippocampal PI response of 7a was blocked by lower concentrations of pirenzepine (8) or by higher concentrations of either AF-DX 116 (9) or p-fluorohexahydrosiladifenidol (10), suggesting that a low concentrations 7a selectively stimulates PI turnover through M1 receptors.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Safety of Quinuclidin-3-yl acetate, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 827-61-2

Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H53N | ChemSpider

Related Products of 827-61-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.827-61-2, Name is Quinuclidin-3-yl acetate, molecular formula is C9H15NO2. In a Patent£¬once mentioned of 827-61-2

Optically active 3 – the preparation method of the quinine is mellow (by machine translation)

The invention relates to a method for synthesizing intermediate, which belongs to the field of organic synthesis. In particular to a simple operation, low cost, and is suitable for industrial production of optically active 3 – the preparation method of the quinine is mellow. In order to 4 – piperidine carboxylic acid as the starting material, through esterification, pro-nuclear substituted, Dieckmann condensation, decarboxylation, salt, reduction, acetylation, chemically so as to obtain the intermediate optically active 3 – the quinine is mellow. The above reaction equation is as follows: (by machine translation)

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Related Products of 827-61-2, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about Related Products of 827-61-2

Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H35N | ChemSpider

Electric Literature of 5291-32-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.5291-32-7, Name is APR-246, molecular formula is C10H17NO3. In a Article£¬once mentioned of 5291-32-7

Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells

NRF2 (NFE2L2) is one of the main regulators of the antioxidant response of the cell. Here we show that in cancer cells NRF2 targets are selectively upregulated or repressed through a mutant p53-dependent mechanism. Mechanistically, mutant p53 interacts with NRF2, increases its nuclear presence and resides with NRF2 on selected ARE containing gene promoters activating the transcription of a specific set of genes while leading to the transcriptional repression of others. We show that thioredoxin (TXN) is a mutant p53-activated NRF2 target with pro-survival and pro-migratory functions in breast cancer cells under oxidative stress, while heme oxygenase 1 (HMOX1) is a mutant p53-repressed target displaying opposite effects. A gene signature of NRF2 targets activated by mutant p53 shows a significant association with bad overall prognosis and with mutant p53 status in breast cancer patients. Concomitant inhibition of thioredoxin system with Auranofin and of mutant p53 with APR-246 synergizes in killing cancer cells expressing p53 gain-of-function mutants.

Electric Literature of 5291-32-7, Interested yet? Read on for other articles about Electric Literature of 5291-32-7!

Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H172N | ChemSpider

Related Products of 827-61-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.827-61-2, Name is Quinuclidin-3-yl acetate, molecular formula is C9H15NO2. In a Article£¬once mentioned of 827-61-2

A practical chemoenzymatic process to access (R)-quinuclidin-3-ol on scale

(¡À)-3-Butyryloxyquinuclidinium butyrate 6 (2 M, 571 g/L), prepared from (¡À)-quinuclidin-3-ol 1 and butyric anhydride, undergoes enantioselective hydrolysis by an Aspergillus melleus protease {1.0% (w/v)} in water in the presence of Ca(OH)2 to keep the reaction at pH 7 and trap butyric acid that is introduced as part of (¡À)-6 and generated by the enzymatic hydrolysis. After a 24 h period, extraction with n-heptane provides (R)-quinuclidin-3-yl butyrate 5a, which, on methanolysis with Na2CO3, is converted into (R)-1, a common pharmacophore of neuromodulators acting on muscarinic receptors, in 96% ee and 42% overall yield from (¡À)-1. The unwanted antipode (S)-1, which is extracted into n-butanol and purified via its hydrochloride salt in 89% ee and 40% overall yield from (¡À)-1, can be racemized by the catalysis of Raney Co at 140C under an atmosphere of H2 (5 kg/cm2) to regenerate (¡À)-1 in 97% yield.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Related Products of 827-61-2, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 827-61-2

Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H75N | ChemSpider

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 827-61-2, Name is Quinuclidin-3-yl acetate,introducing its new discovery., name: Quinuclidin-3-yl acetate

Visible-Light-Mediated Metal-Free Difunctionalization of Alkenes with CO2 and Silanes or C(sp3)?H Alkanes

Catalytic alkene difunctionalization via Si?H and C?H activations represents an ideal atom- and step-economic pathway for quick assembly of molecular complexity. We herein developed a visible-light-promoted metal-free difunctionalization of alkenes using abundant CO2 and readily available Si?H and C(sp3)?H bonds as feedstocks. Through the merger of photoredox and hydrogen-atom-transfer catalysis, a variety of value-added compounds, such as beta-silacarboxylic acids and acids bearing a gamma-heteroatom (e.g., N, O, S) could be directly accessed from simple alkenes in a redox-neutral fashion.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: Quinuclidin-3-yl acetate, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 827-61-2, in my other articles.

Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H63N | ChemSpider

Electric Literature of 123536-14-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.123536-14-1, Name is (R)-3-Aminoquinuclidine dihydrochloride, molecular formula is C7H16Cl2N2. In a Patent£¬once mentioned of 123536-14-1

SUBSTITUTED SPIRO-AMIDE COMPOUNDS

Substituted spiro-amide compounds corresponding to formula 1 in which R5 through R8, D, X, Y and Z have defined meanings, processes for preparing such spiro-amide compounds, pharmaceutical compositions containing such compounds, and methods of using such spiro-amide compounds for treating and/or inhibiting disorders or disease states mediated at least in part by the bradykinin 1 receptor

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Electric Literature of 123536-14-1, you can also check out more blogs aboutElectric Literature of 123536-14-1

Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H129N | ChemSpider

Related Products of 827-61-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.827-61-2, Name is Quinuclidin-3-yl acetate, molecular formula is C9H15NO2. In a Article£¬once mentioned of 827-61-2

IDrugs and idevices discovery research: Preclinical assays, techniques, and animal model studies for ocular hypotensives and neuroprotectants

Discovery ophthalmic research is centered around delineating the molecular and cellular basis of ocular diseases and finding and exploiting molecular and genetic pathways associated with them. From such studies it is possible to determine suitable intervention points to address the disease process and hopefully to discover therapeutics to treat them. An investigational new drug (IND) filing for a new small-molecule drug, peptide, antibody, genetic treatment, or a device with global health authorities requires a number of preclinical studies to provide necessary safety and efficacy data. Specific regulatory elements needed for such IND-enabling studies are beyond the scope of this article. However, to enhance the overall data packages for such entities and permit high-quality foundation-building publications for medical affairs, additional research and development studies are always desirable. This review aims to provide examples of some target localization/verification, ocular drug discovery processes, and mechanistic and portfolio-enhancing exploratory investigations for candidate drugs and devices for the treatment of ocular hypertension and glaucomatous optic neuropathy (neurodegeneration of retinal ganglion cells and their axons). Examples of compound screening assays, use of various technologies and techniques, deployment of animal models, and data obtained from such studies are also presented.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about Related Products of 827-61-2

Reference£º
Quinuclidine – Wikipedia,
Quinuclidine | C7H82N | ChemSpider