Category: quinuclidine

Liu, Haitao published the artcileRobust and flexible transparent protective film fabricated with an ambient-curable hybrid resin, Recommanded Product: 4,4-Diaminodicyclohexyl methane, the publication is Journal of Coatings Technology and Research (2021), 18(4), 1065-1073, database is CAplus.

An ambient-curable hybrid resin (ACHR) terminated with trimethoxysilane functional groups, synthesized through a simple ring-opening reaction between 3-glycidyloxypropyltrimethoxysilane (KH560) and 4,4′-methylenebis (cyclohexylamine) (PACM), was applied to the surface of a transparent organic polymer to produce a robust, flexible, and transparent protective hybrid film, moisture cured at room temperature The structure, morphol., and optical, mech., and thermal properties of the obtained hybrid film were evaluated. The hybrid film allowed the transmittance of more than 87% of visible light (at 600 nm), maintaining almost the same high transparency as bare PET film. The unique flexible segments and rigid segments in the inorganic-organic hybrid structure of the film realized superior resistance to bending and scratching. The hybrid film-coated PET demonstrated excellent flexibility, with an extremely low bending radius, illustrated by wrapping around a 1-mm mandrel bar without cracking. In addition, the hybrid film exhibited superior pencil hardness (of 2H) and excellent wear durability, i.e., no scratching after being subjected to 200 abrasion cycles using #0000 steel wool under a 19.6 kPa load. The robust, flexible, and transparent protective film developed here, and its simple and efficient preparation method, should have extensive application prospects.

Journal of Coatings Technology and Research published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Recommanded Product: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Zuo, Hanqi published the artcileEffect of structure on the properties of ambient-cured coating films prepared via a Michael addition reaction based on an acetoacetate-modified castor oil prepared by thiol-ene coupling, Recommanded Product: 4,4-Diaminodicyclohexyl methane, the publication is Progress in Organic Coatings (2019), 27-33, database is CAplus.

The Michael addition reaction was used to create ambient curable film materials based on an acetoacetate-modified castor oil, and a multifunctional alamine was prepared The thiol-ene coupling reaction could change the proportion of hydroxyl groups in the castor oil, thereby improving the crosslinking d. and mech. properties of the coating films. The acetoacetate-modified castor oil was achieved in two steps. First, the C=C bonds of castor oil were coupled using a thiol-ene coupling reaction, which has a high conversion rate and few byproducts. Second, acetoacetate-modified castor oil was prepared by a transesterification reaction between tert-Bu acetoacetate and modified castor oil. The acetoacetate-modified castor oil was characterized by NMR (NMR), Fourier transform IR spectroscopy (FTIR), gel permeation chromatog. (GPC) and viscosity measurements. Finally, coating films were prepared from the acetoacetate-modified castor oil and 4,4-diaminecyclohexylmethane via a Michael addition reaction at room temperature (25 °C). The mech. properties were noticeably improved compared to those of the unmodified castor oil film. The tensile properties increased from 0.68 MPa to 1.76 MPa, and the glass transition temperature (T_g) increased by approx. 30 °C.

Progress in Organic Coatings published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C10H9NO4S, Recommanded Product: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Lukesh, John C. published the artcileVinblastine 20′ Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance, Application In Synthesis of 20029-52-1, the publication is Journal of Medicinal Chemistry (2017), 60(17), 7591-7604, database is CAplus and MEDLINE.

A series of 180 vinblastine 20′ amides were prepared in three steps from com. available starting materials, systematically exploring a typically inaccessible site in the mol. enlisting a powerful functionalization strategy. Clear structure-activity relationships and a structural model were developed in the studies which provided many such 20′ amides that exhibit substantial and some even remarkable enhancements in potency, many that exhibit further improvements in activity against a Pgp overexpressing resistant cancer cell line, and an important subset of the vinblastine analogs that display little or no differential in activity against a matched pair of vinblastine sensitive and resistant (Pgp overexpressing) cell lines. The improvements in potency directly correlated with target tubulin binding affinity, and the reduction in differential functional activity against the sensitive and Pgp overexpressing resistant cell lines was found to correlate directly with an impact on Pgp-derived efflux.

Journal of Medicinal Chemistry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Application In Synthesis of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Ou, Shuo-jun published the artcileDetermination of seven kinds of alkylamines in food contact plastic materials by amidation coupled with high performance liquid chromatography-quadrupole time-of-flight mass spectrometer, Name: 4,4-Diaminodicyclohexyl methane, the publication is Fenxi Huaxue (2020), 48(3), 413-422, database is CAplus.

A high performance liquid chromatog.-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) method for determination of seven kinds of alkylamines was established. Samples were amidated with 0.4% benzyl chloroformate (Cbz-Cl) in acetonitrile-sodium carbonate solution (50:50, V/V). The amidated conditions, including concentration of sodium carbonate solution (1.5%, m/V), benzyl chloroformate ratio and amount of sodium chloride (1.5 g), were optimized by response surface methodol. Under the optimized chromatog. and mass spectrometer conditions, the data were collected with electrospray ionization (ESI) sources under pos. ion mode. The calibration curves of seven kinds of alkylamines showed good linearity in concentration range of 1.0-500μg/L(R² > 0.9957). The average recoveries were 82.0-108.0%, the limits of detection and quantification were 0.5-1.0μg/kg and 2.0-4.0μg/kg, resp., and the relative standard deviations (RSDs) were 3.5-6.8%. This method is efficient and easy to be operated, and has good sensitivity, high precision and accuracy in the determination of seven alkylamines in food contact plastic materials.

Fenxi Huaxue published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Name: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

O’Donnell, Michael published the artcile2-Chloro-4-tetrafluorophenoxypyrimidine: a versatile reagent for C-2 prior to C-4 functionalizations, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, the publication is Tetrahedron Letters (2016), 57(17), 1882-1884, database is CAplus.

A novel synthetic route to 2,4-functionalized pyrimidines is reported. The approach uses 2-chloro-4-tetrafluorophenoxypyrimidine, that enables sequential palladium catalyzed functionalization at the pyrimidine C-2 position, followed by S_NAr displacement with diverse amines at C-4. The broad utility of this “C-2 then C-4” functionalization sequence has been demonstrated with a range of cross-coupling partners and amines.

Tetrahedron Letters published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Gholivand, Khodayar published the artcileSynthesis and crystal structure of phosphonic acid and bisphosphoramidate derivatives: QSAR studies of their anti-fungal potential on Macrophomina Phaseolina (Tassi) Goid, Application In Synthesis of 1761-71-3, the publication is Journal of the Iranian Chemical Society (2021), 18(7), 1591-1606, database is CAplus.

Abstract: A series of phosphonic acid and bisphosphoramidate derivatives were synthesized and characterized. The bioactivities against the fungal pathogen Macrophomina phaseolina and human acetylcholinesterase AChE enzyme were studied using QSAR based on multiple linear regression. L17, with (p-Cl-C6H4-NH) (p-Cl-C6H4)C(H)P(O)(OC2H5)2 skeleton, demonstrated a great mortality on the M. phaseolina mycelial growth by 83% inhibition at 150 mg/L; the other tested derivative showed moderate to weak antifungal activity against the fungus. QSAR model based on the GA-MLR method revealed the importance of 3D descriptors (De, Mor18e, H8m, and Mor30p) on the antifungal activity. It showed good capability in predicting the fungicidal activity of the studied mols. Another derivative, L5, with (m-CH3-NC5H4-NH)(m-CH3-C6H4)C(H)P(O)(OCH3)2 skeleton displays the most potent anti-AChE activity. The electronic parameters, ΔEL-H, and ELUMO, have the highest contribution of human AChE. The authors suggest that these models could be usefully employed in designing more effective crop protection compounds without side effects on non-target organisms.

Journal of the Iranian Chemical Society published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Application In Synthesis of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Sakurai, Yu published the artcileTargeted delivery of lipid nanoparticle to lymphatic endothelial cells via anti-podoplanin antibody, SDS of cas: 1353016-70-2, the publication is Journal of Controlled Release (2022), 379-387, database is CAplus and MEDLINE.

Lymphatic endothelial cells (LECs) that form lymphatic vessels play a pivotal role in immune regulation. It was recently reported that LECs suppress the antigen-dependent anti-tumor immunity in cancer tissues. Thus, regulating the function of LECs is a promising strategy for cancer therapy. The objective of this study was to develop a method for the selective delivery of small interfering RNA (siRNA) to LECs. For this purpose, the siRNA was formulated into nanoparticles (LNPs) to prevent them from being degraded in body fluids and to facilitate their penetration of the cell membrane. A breakthrough technol. for achieving this is ONPATTRO, a worlds first siRNA drug. Since LNPs are taken up by hepatocytes relatively well via low-d. lipoprotein receptors, most of the LNP systems that have been developed so far target hepatocytes. In this study, we report on the development of a new method for the rapid and convenient method for modifying LNPs with antibodies using the CLick reaction on the Interface of the nanoParticle (CLIP). The CLIP approach was faster and more versatile than the conventional method using amide coupling. As a demonstration, we report on the LEC-targeted siRNA delivery by using antibody-modified LNPs both in vitro and in vivo. The method used for the modification of LNPs is highly promising and has the potential for expanding the LNP-based delivery of nucleic acids in the future.

Journal of Controlled Release published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, SDS of cas: 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

McNelles, Stuart A. published the artcileRapid Synthesis of Functionalized High-Generation Polyester Dendrimers via Strain-Promoted Alkyne-Azide Cycloaddition, Formula: C19H15NO3, the publication is Macromolecules (Washington, DC, United States) (2017), 50(20), 7993-8001, database is CAplus.

Preparation of structurally perfect high-generation dendrimer libraries with different peripheral groups is challenging as divergent synthesis introduces peripheral defects and convergent synthesis leads to low yields. Here, we prepare a third-generation polyester dendron based on the bisMPA monomer structure, having eight peripheral azide functionalities, as an “inner” dendron. We also prepare a series of low-generation “outer” dendrons (G2 and G3) with various peripheral groups, including aromatic, aliphatic, and polar structures, each having a single dibenzoazacyclooctyne (DIBAC) at the core. Efficient strain-promoted azide-alkyne cycloaddition (SPAAC) enables quant. coupling between the outer and inner dendrons, producing high-generation (G5 and G6) dendrimers in a single coupling step. Characterization by NMR and mass spectrometry shows that the coupling products are structurally perfect. Using this strategy, we prepared a small dendrimer library that includes the first high-generation monodisperse peripherally PEGylated dendrimers as well as a structure bearing bulky protected amino acids at its periphery. This general strategy allows for rapid, efficient, and quant. preparation of high-generation dendrimers with a variety of peripheral and core functional groups, starting from small, easily prepared fragments.

Macromolecules (Washington, DC, United States) published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Formula: C19H15NO3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Alam, Todd M. published the artcileDynamic heterogeneity and nanophase separation in rubber-toughened amine-cured highly cross-linked polymer networks, Related Products of quinuclidine, the publication is Polymer Testing (2022), 107616, database is CAplus.

Solid state NMR spectroscopy and small-to wide-angle X-ray scattering (SWAXS) methods were used to characterize the heterogeneous dynamics and polymer domain structure in rubber modified thermoset materials containing the diglycidyl ether of bisphenol A (DGEBA) epoxy resin and a mixture of Jeffamine reactive rubber and 4,4-diaminodicyclohexylmethane (PACM) amine curing agent. The polymer chain dynamics and morphologies as a function of the PACM/Jeffamine ratio were determined Using dipolar-filtered NMR experiments, the resulting networks are shown to be composed of mobile and rigid regions that are separated on nanometer length scales, along with a dynamically immobilized interface region. Proton NMR spin diffusion experiments measured the dimensions of the mobile phase to range between 9 and 66 nm and varied with the relative PACM concentration Solid state ¹³C magic angle spinning NMR experiments show that the highly mobile phase is composed entirely of the dynamically flexible polyether chains of the Jeffamine rubber, the immobilized interface region is a mixture of DGEBA, PACM, and the Jeffamine rubber, with the PACM crosslinked to DGEBA predominantly residing in the rigid phase. The SWAXS results showed compositional nanophase separation spanning the 11-77 nm range. These measurements of the nanoscale compositional and dynamic heterogeneity provide mol. level insight into the very broad and controllable glass transition temperature distributions observed for these highly crosslinked polymer networks.

Polymer Testing published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Gruzdev, M. S. published the artcileSynthesis and study of vitrescent materials based on the alkoxybenzoic acids derivatives and triethanolamine, COA of Formula: C13H16O2, the publication is Russian Journal of General Chemistry (2013), 83(4), 652-658, database is CAplus.

Alkoxybenzoic, benzyloxybenzoic, cyclohexylbenzoic, and benzoic acid triesters of triethanolamine (RCOOCH₂CH₂)₃N [R = 4-H(CH₂)_nOC₆H₄, 4-PhCH₂OC₆H₄, 4-cyclohexylphenyl, Ph; n = 3, 4, 6, 9, 12] (I) were prepared as potential liquid crystalline compounds; the likelihood of I [R = 4-H(CH₂)_nOC₆H₄, 4-PhCH₂OC₆H₄, 4-cyclohexylphenyl, Ph; n = 1-12] being discotic mesogens was determined by mol. mechanics calculations and compared to the behavior of the prepared compounds I [R = 4-H(CH₂)_nOC₆H₄; n = 1-8] were predicted to be liquid crystals, while the behaviors of I [R = 4-Me(CH₂)_nOC₆H₄; n = 9-12] were not clear from the calculations; I (4-PhCH₂OC₆H₄, 4-cyclohexylphenyl, Ph) were predicted not to be liquid crystals. The m.ps., glass and phase transition temperatures, and heats of melting, crystallization, and phase transition for I [R = 4-H(CH₂)_nOC₆H₄, 4-PhCH₂OC₆H₄, 4-cyclohexylphenyl, Ph; n = 3, 4, 6, 9, 12] were determined

Russian Journal of General Chemistry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, COA of Formula: C13H16O2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider