Heterocyclic Building Blocks-Quinuclidine

Hatter, Christine B. published the artcileMicromechanical response of two-dimensional transition metal carbonitride (MXene) reinforced epoxy composites, Name: 4,4-Diaminodicyclohexyl methane, the publication is Composites, Part B: Engineering (2020), 107603, database is CAplus.

MXenes have attracted much attention as fillers in polymer composites due to their superior elec. and mech. properties making them ideal for creating multifunctional composites. In this work, Ti₃CN-epoxy composites were prepared via solvent processing and cured with amine-based hardener. The effects of Ti₃CN content in the epoxy system on the thermal degradation behavior and micromech. properties were investigated. The extent of intercalation of epoxy between MXene flakes was analyzed by transmission electron microscopy. Nanoindentation anal. of MXene-epoxy composites exhibited improved mech. properties with increasing MXene content with highest increase to 12.8 GPa Young’s modulus for 90 wt% Ti₃CN. An increase in creep resistance of composites was observed at maximum loading of Ti₃CN by 46% compared to neat epoxy.

Composites, Part B: Engineering published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Name: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Zhang, H. J. published the artcileEffect of free-volume holes on static mechanical properties of epoxy resins studied by positron annihilation and PVT experiments, Quality Control of 1761-71-3, the publication is Polymer (2020), 122225pp., database is CAplus.

The tensile, flexural, and fracture toughness properties of seven chem. different amine-cured epoxy resins were studied. Positron annihilation lifetime and pressure-volume-temperature (PVT) experiments were performed on each epoxy resin to characterize the average size and fraction, resp., of free-volume holes. A neg. correlation between hole fraction and hole size was revealed for these chem. different epoxy resins. Better tensile and flexural mech. properties (higher tensile modulus and lower tensile strain at break; higher flexural modulus, higher flexural strength, and lower flexural strain at break) were clearly observed for epoxy resins with smaller hole size and higher hole fraction. However, no clear relationship between fracture toughness and hole properties was found. The correlations between (tensile and flexural) static mech. properties and hole properties for chem. different epoxy resins should provide guidance for further improvements in the mech. properties of carbon fiber-reinforced polymers.

Polymer published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C18H20N2O12, Quality Control of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Zhang, H. J. published the artcileEffect of Free-Volume Hole Fraction on Dynamic Mechanical Properties of Epoxy Resins Investigated by Pressure-Volume-Temperature Technique, COA of Formula: C13H26N2, the publication is Journal of Physical Chemistry B (2020), 124(9), 1824-1832, database is CAplus and MEDLINE.

Dynamic mech. anal. experiments were carried out to investigate the mech. properties of four types of chem. different epoxy resins. Pressure-volume-temperature (PVT) experiments were performed to determine the free-volume hole fraction (h_PVT) of each epoxy resin using the Simha-Somcynsky lattice-hole theory. Using the Williams-Landel-Ferry equation, the correlations between the relative hole fraction (1 – h_PVT^T_r/h_PVT, where h_PVT^T_r is the hole fraction at a reference temperature T_r) and four typical parameters reflecting dynamic mech. properties [storage modulus (E’), loss modulus (E”), damping factor (tanδ), and complex viscosity (|η*|)] were studied at from T_g(PVT) (the glass transition temperature determined by PVT data) to T_g(PVT) + 100°C. At from T_g(Eonset‘₎ (temperature corresponding to the intersection of the two tangent fitting lines in the E'(T) curve indicating the glassy-state and glass-transition stages) to T_g(PVT) + 100°C, the variations in the four dynamic mech. parameters with a relative hole fraction could be separated into two distinct categories: (i) log[E'(T)] and log[|η*|(T)] decreased linearly to their min. values and then remained nearly unchanged with increasing relative hole fraction, and (ii) log[E”(T)] and log[tanδ(T)] first increased monotonically to their maximum values and then decreased linearly with the increasing relative hole fraction. This study demonstrates that the PVT technique is a feasible and reliable exptl. method to determine the hole fractions of thermoset polymers.

Journal of Physical Chemistry B published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is 0, COA of Formula: C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Kashida, Hiromu published the artcileInsulator base pairs for lighting-up perylenediimide in a DNA duplex, Related Products of quinuclidine, the publication is Chemistry – A European Journal (2010), 16(38), 11554-11557, S11554/1-S11554/18, database is CAplus and MEDLINE.

Perylenediimide (PDI) is highly quenched by nucleobases, which greatly restricts its application as a fluorescent probe. Here, the authors propose “insulator base pairs” tethering cyclohexane ring through D-threoninol. When “insulator base pairs” were inserted between PDI and nucleobases, the quantum yield of PDI drastically increased several thousand-fold. The “insulator base pairs” reported here also have the potential to increase the quantum yields of other fluorophores.

Chemistry – A European Journal published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Quattropani, Anna published the artcilePharmacophore-Based Design of Novel Oxadiazoles as Selective Sphingosine-1-phosphate (S1P) Receptor Agonists with in vivo Efficacy, Recommanded Product: 4-Cyclohexylbenzoic acid, the publication is ChemMedChem (2015), 10(4), 688-714, database is CAplus and MEDLINE.

Sphingosine-1-phosphate (S1P) receptor agonists have shown promise as therapeutic agents for multiple sclerosis (MS) due to their regulatory roles within the immune, central nervous system, and cardiovascular system. Here, the design and optimization of novel [1,2,4]oxadiazole derivatives as selective S1P receptor agonists are described. The structure-activity relation exploration was carried out on the three dominant segments of the series: modification of the polar head group (P), replacement of the oxadiazole linker (L) with different five-membered heterocycles, and the use of diverse 2,2′-disubstituted biphenyl moieties as the hydrophobic tail (H). All three segments have a significant impact on potency, S1P receptor subtype selectivity, physicochem. properties, and in vitro absorption, distribution, metabolism, excretion and toxicity (ADMET) profile of the compounds From these optimization studies, a selective S1P₁ agonist, N-methyl-N-(4-{5-[2-methyl-2′-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)glycine (45), and a dual S1P_1,5 agonist, N-methyl-N-(3-{5-[2′-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}benzyl)glycine (49), emerged as frontrunners. These compounds distribute predominantly in lymph nodes and brain over plasma and induce long lasting decreases in lymphocyte count after oral administration. When evaluated head-to-head in an exptl. autoimmune encephalomyelitis mouse model, together with the marketed drug fingolimod, a pan-S1P receptor agonist, S1P_1,5 agonist 49 demonstrated comparable efficacy while S1P₁-selective agonist 45 was less potent. Compound 49 is not a prodrug, and its improved property profile should translate into a safer treatment of relapsing forms of MS.

ChemMedChem published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Recommanded Product: 4-Cyclohexylbenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Chaudhari, Chandan published the artcileOne-pot synthesis of cyclohexylamine and N-aryl pyrroles via hydrogenation of nitroarenes over the Pd_0.5Ru_0.5-PVP catalyst, Category: quinuclidine, the publication is New Journal of Chemistry (2021), 45(22), 9743-9746, database is CAplus.

The direct synthesis of cyclohexylamine via the hydrogenation of nitrobenzene over monometallic (Pd, Ru or Rh) and bimetallic (Pd_xRu_1-x) catalysts was studied. The Pd_0.5Ru_0.5-PVP catalyst was the most effective catalyst for this reaction. The catalyst can be reused and applied for the synthesis of N-aryl pyrroles I (R = Ph, 4-chlorophenyl, pyridin-3-yl, etc.) and quinoxalines such as 2,3-diphenylquinoxaline and 2,3-diphenyl-1,2,3,4-tetrahydroquinoxaline from nitrobenzenes RNO₂.

New Journal of Chemistry published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Category: quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Shoji, Naoyuki published the artcileEffect of conversion on epoxy resin properties: Combined molecular dynamics simulation and experimental study, Related Products of quinuclidine, the publication is Polymer (2022), 125041, database is CAplus.

We investigated epoxy resin consisting of diglycidyl ether of bisphenol A (DGEBA) and bis-(p-aminocyclohexyl)methane (PACM) and found that the d. increased and decreased in the low- and high-conversion regions, resp., by using experiments and all-atom (AA) mol. dynamics (MD) simulations. To understand this feature qual., we conducted course-grained (CG) MD simulations. For the flexible and rigid CG models, the calculated d. increased and decreased monotonically, resp., in contrast to the exptl. d. To develop a more realistic CG model, which is denoted as CG-EP, we derived angular parameters based on AA-MD simulations. It was found that the CG-EP successfully reproduced the trend of the exptl. d., suggesting the importance of mol. flexibility. In addition, the progress of the conversion monotonically increased the free volume hole size, which is consistent with the result of positron annihilation lifetime spectroscopy. Furthermore, we exptl. observed that the Young’s modulus suddenly decreased at 50%, as the conversion progressed. The CG anal. indicated that this trend was also attributed to the mol. flexibility.

Polymer published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C39H35N5O8, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Yoshikawa, Chiaki published the artcileWell-defined monolith morphology regulates cell adhesion and its functions, HPLC of Formula: 1761-71-3, the publication is Materials Science & Engineering, C: Materials for Biological Applications (2019), 110108, database is CAplus and MEDLINE.

Hydrophilic epoxy resin-based monoliths were employed as cell culture substrates. The monoliths were made of a porous material with a bicontinuous structure that consisted of a porous channel and a resin skeleton. Monolith disks were prepared with a skinless surface through polymerization-induced spinodal decomposition-type phase separation The pore sizes, which were well controlled by the polymerization temperature, ranged from 70 to 380 nm. The quantity of protein adsorbed per unit area and the early-stage adhesion of HepG2 cells on the monolith substrates were independent of pore size, meaning they were not affected by surface topol. Long-term cell adhesion, as indicated by adherent cell number and shape, as well as liver-specific gene expression were significantly affected by pore size. In terms of cell shape, number, and gene expression, pores of approx. 200 nm were most suitable for HepG2 cell growth. These results highlight the importance of monolith morphol. for use as a cell culture substrate. The well-controlled morphol. demonstrated in this work indicates monoliths are capable of supporting growth for various types of cells in a range of applications.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C6H6N2O, HPLC of Formula: 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Miyahara, Koki published the artcileA Cu-free clickable surface with controllable surface density, Application In Synthesis of 1353016-70-2, the publication is Colloid and Polymer Science (2019), 297(6), 927-931, database is CAplus.

A Cu-free clickable polymer was synthesized and used to dip-coat plastic substrates to prepare Cu-free clickable surfaces. The surface d. of dibenzocyclooctyne moieties was quantified using an azide-conjugated fluorophore and a conventional fluorometer, indicating that the clickable moieties displayed on a dip-coated surface were accessible from solutes in water. The present approach also succeeded in the control of the surface d. of the clickable moieties. Azide-conjugated oligo DNA was immobilized on the surface using a Cu-free click reaction. [Figure not available: see fulltext.].

Colloid and Polymer Science published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Application In Synthesis of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Reddi, Rambabu N. published the artcileSite-specific labeling of endogenous proteins using CoLDR chemistry, SDS of cas: 1353016-70-2, the publication is Journal of the American Chemical Society (2021), 143(48), 20095-20108, database is CAplus and MEDLINE.

Chem. modifications of native proteins can affect their stability, activity, interactions, localization, and more. However, there are few nongenetic methods for the installation of chem. modifications at a specific protein site in cells. Here we report a covalent ligand directed release (CoLDR) site-specific labeling strategy, which enables the installation of a variety of functional tags on a target protein while releasing the directing ligand. Using this approach, we were able to label various proteins such as BTK (Bruton’s tyrosine kinase), K-Ras^G12C, and SARS-CoV-2 PL^pro with different tags. For BTK we have shown selective labeling in cells of both alkyne and fluorophores tags. Protein labeling by traditional affinity methods often inhibits protein activity since the directing ligand permanently occupies the target binding pocket. We have shown that using CoLDR chem., modification of BTK by these probes in cells preserves its activity. We demonstrated several applications for this approach including determining the half-life of BTK in its native environment with minimal perturbation, as well as quantification of BTK degradation by a noncovalent proteolysis targeting chimera (PROTAC) by in-gel fluorescence. Using an environment-sensitive “turn-on” fluorescent probe, we were able to monitor ligand binding to the active site of BTK. Finally, we have demonstrated efficient CoLDR-based BTK PROTACs (DC₅₀ < 100 nM), which installed a CRBN binder onto BTK. This approach joins very few available labeling strategies that maintain the target protein activity and thus makes an important addition to the toolbox of chem. biol.

Journal of the American Chemical Society published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, SDS of cas: 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider