Heterocyclic Building Blocks-Quinuclidine

Silverberg, Lee J. published the artcileSynthesis and spectroscopic properties of 2,3-diphenyl-1,3-thiaza-4-one heterocycles, Product Details of C6H10O2S, the publication is International Journal of Chemistry (Toronto, ON, Canada) (2015), 7(2), 150-162, database is CAplus.

Synthetic and spectroscopic data (¹H NMR, ¹³C NMR, IR, UV/Vis) for a series of six 2,3-diphenyl-1,3-thiaza-4-one heterocycles which differed in ring size and substitution was reported. The results showed that there are significant differences in spectroscopic signals common to all six compounds Distinctions was made among the compounds using the IR absorbance of the C4 carbonyl and the ¹H NMR signal at C2, and to a lesser extent the ¹³C NMR signal at C4 and the UV/Vis spectrum.

International Journal of Chemistry (Toronto, ON, Canada) published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C10H16Br3N, Product Details of C6H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

LeValley, Paige J. published the artcileDesign of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications, Formula: C19H15NO3, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(50), 6923-6926, database is CAplus and MEDLINE.

An approach for the design of functionalized cyclic peptides is established for use in 3D cell culture and in cell targeting. Sequential orthogonal click reactions, specifically a photoinitiated thiol-ene and strain promoted azide-alkyne cycloaddition, were utilized for peptide cyclization and conjugation relevant for biomaterial and biomedical applications, resp.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Formula: C19H15NO3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Nara, Mayuko published the artcileWhite-Light Emission and Tunable Luminescence Colors of Polyimide Copolymers Based on FRET and Room-Temperature Phosphorescence, Quality Control of 1761-71-3, the publication is ACS Omega (2020), 5(24), 14831-14841, database is CAplus and MEDLINE.

Thermally stable copolyimide (CoPI) films exhibiting high optical transparency and room-temperature phosphorescence (RTP) were prepared by copolymerizing fluorescent dianhydride and brominated phosphorescent dianhydride with an alicyclic diamine. The CoPI films underwent a 5 wt % degradation at a temperature higher than 349°C and exhibited dual fluorescent and phosphorescent emissions owing to their efficient Forster resonance energy transfer from the fluorescent to phosphorescent dianhydride moieties in the main chains, followed by an intersystem crossing from the singlet to triplet state of the latter moiety atoms. The CoPIs displayed bright RTP under a vacuum with various colors produced when adjusting the copolymerization ratio. CoPI with 5 mol % phosphorescent moiety (CoPI-05) emitted white light with high optical transparency owing to the suppression of the PI chain aggregation that causes a yellowish coloration. The copolymerization of fluorescent and phosphorescent PI moieties can control the photoluminescent properties of PI films and is applicable to color-tunable solid-state emitters, ratiometric oxygen sensors, and solar-spectrum converters.

ACS Omega published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Quality Control of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Fujiwara, Eisuke published the artcileUltrafast Spectroscopic Analysis of Pressure-Induced Variations of Excited-State Energy and Intramolecular Proton Transfer in Semi-Aliphatic Polyimide Films, Safety of 4,4-Diaminodicyclohexyl methane, the publication is Journal of Physical Chemistry B (2021), 125(9), 2425-2434, database is CAplus and MEDLINE.

The relationship between the photoexcitation dynamics and the structures of semi-aliphatic polyimides (3H-PIs) was investigated using ultrafast fluorescent emission spectroscopy at atm. and increased pressures of up to 4 GPa. The 3H-PI films exhibited prominent fluorescence with extremely large Stokes shifts (Δν > 10 000 cm^-1) through an excited-state intramol. proton transfer (ESIPT) induced by keto-enol tautomerism at the isolated dianhydride moiety. The incorporation of bulky -CH₃ and -CF₃ side groups at the diamine moiety of the PIs increased the quantum yields of the ESIPT fluorescence owing to an enhanced interchain free volume In addition, 3H-PI films emitted another fluorescence at shorter wavelengths originating from closely packed polyimide (PI) chains (in aggregated forms), which was mediated through a Foddorster resonance energy transfer (FRET) from an isolated enol form into aggregated forms. The FRET process became more dominant than the ESIPT process at higher pressures owing to an enhancement of the FRET efficiency caused by the increased dipole-dipole interactions associated with a densification of the PI chain packing. The efficiency of the FRET rapidly increased by applying pressure up to 1 GPa owing to an effective compression of the interchain free volume and addnl. gradually increased at higher pressures owing to structural and/or conformational changes in the main chains.

Journal of Physical Chemistry B published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Safety of 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Butler, Christopher R. published the artcileAminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality, Safety of 3-(Trifluoromethyl)oxetan-3-amine hydrochloride, the publication is Journal of Medicinal Chemistry (2017), 60(1), 386-402, database is CAplus and MEDLINE.

A growing subset of β-secretase (BACE1) inhibitors for the treatment of Alzheimer’s disease (AD) utilizes an anilide chemotype that engages a key residue (Gly230) in the BACE1 binding site. Although the anilide moiety affords excellent potency, it simultaneously introduces a third hydrogen bond donor that limits brain availability and reveals a potential metabolic site leading to the formation of an aniline, a structural motif of potential safety concern. The authors report herein an alternative aminomethyl linker that delivers similar potency and improved brain penetration relative to the amide moiety. Optimization of this series identified analogs with an excellent balance of ADME properties and potency, however potential drug-drug interactions (DDI) were predicted based on CYP2D6 affinities. Generation and anal. of key BACE1 and CYP2D6 crystal structures identified strategies to obviate the DDI liability, leading to compound I which exhibits robust in vivo efficacy as a BACE1 inhibitor.

Journal of Medicinal Chemistry published new progress about 1268883-21-1. 1268883-21-1 belongs to quinuclidine, auxiliary class Trifluoromethyl,Fluoride,Oxetane,Salt,Amine, name is 3-(Trifluoromethyl)oxetan-3-amine hydrochloride, and the molecular formula is C4H7ClF3NO, Safety of 3-(Trifluoromethyl)oxetan-3-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Koshel, S. G. published the artcileSynthesis of cyclohexylbenzoic acids by liquid-phase catalytic oxidation of cyclohexyltoluenes, Synthetic Route of 20029-52-1, the publication is Neftekhimiya (1989), 29(2), 257-61, database is CAplus.

Isomeric cyclohexyltoluenes were oxidized by mol. oxygen in glacial AcOH using Co(OAc)₂ as catalyst and AcH as initiator. The reactivity of the cyclohexyltoluene decreased in the order: p– > m– > o-isomer.

Neftekhimiya published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Synthetic Route of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Cheng, Ho Fung published the artcileElectron-Equivalent Valency through Molecularly Well-Defined Multivalent DNA, Related Products of quinuclidine, the publication is Journal of the American Chemical Society (2021), 143(4), 1752-1757, database is CAplus and MEDLINE.

Oligonucleotide-functionalized nanoparticles (NPs), also known as “programmable atom equivalent” (PAEs), have emerged as a class of versatile building blocks for generating colloidal crystals with tailorable structures and properties. Recent studies have shown that, at small size and low DNA grafting d., PAEs can also behave as “electron equivalent” (EEs), roaming through and stabilizing a complementary PAE sublattice. However, it has been challenging to obtain a detailed understanding of EE-PAE interactions and the underlying colloidal metallicity because there is inherent polydispersity in the number of DNA strands on the surfaces of these NPs; thus, the structural uniformity and tailorability of NP-based EEs are somewhat limited. Herein, we report a strategy for synthesizing colloidal crystals where the EEs are templated by small mols., instead of NPs, and functionalized with a precise number of DNA strands. When these molecularly precise EEs are assembled with complementary NP-based PAEs, X-ray scattering and electron microscopy reveal the formation of three distinct “metallic” phases. Importantly, we show that the thermal stability of these crystals is dependent on the number of sticky ends per EE, while lattice symmetry is controlled by the number and orientation of EE sticky ends on the PAEs. Taken together, this work introduces the notion that, unlike conventional electrons, EEs that are mol. in origin can have a defined valency that can be used to influence and guide specific phase formation.

Journal of the American Chemical Society published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Wang, Yaxin published the artcileVisible-Light-Promoted Site-Specific and Diverse Functionalization of a C(sp³)-C(sp³) Bond Adjacent to an Arene, Synthetic Route of 20029-52-1, the publication is ACS Catalysis (2020), 10(12), 6603-6612, database is CAplus.

A strategy for inert C-C bond functionalization is reported. Site-specific cleavage and functionalization of saturated C(sp3)-C(sp3) bond via a visible-light-induced radical process was achieved. The general features of this reaction are: 1-Both linear and cyclic C(sp3)-C(sp3) bonds with a vicinal arene can be specifically functionalized; 2-One carbon is converted into ketone, and the another can be tunably converted into nitrile, peroxide or halide; 3-The typical conditions includes: 1.0 mol% Ru(bpy)3Cl2, 1.0 or 5.0 equiv of Zhdankin reagent, white CFL (24 W), open flask and room temperature These reactions offer a powerful tool to modify carbon skeletons that are intractable by conventional methods. Good selectivity and functional group tolerance, together with mild and open air conditions make these transformations valuable and attractive.

ACS Catalysis published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C9H10O3S, Synthetic Route of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Hui, Xiang published the artcileHighly efficient synthesis of novel bio-based pentamethylene dicarbamate via carbonylation of pentanediamine with ethyl carbamate over well-defined titanium oxide catalysts, Category: quinuclidine, the publication is Catalysis Science & Technology (2022), 12(7), 2315-2327, database is CAplus.

Carbonylation of pentanediamine (PDA) is a green and effective route for the synthesis of pentamethylene dicarbamate (PDC), an important intermediate compound for the preparation of polyurethanes (PUs) and other chems. In this work, TiO₂-101 and TiO₂-110 catalysts, with preferential exposure of (101) and (110) facets, resp., were prepared and studied for the carbonylation of diamines with Et carbamate (EC) to give dicarbamates, e.g., EtO₂C(CH₂)₇NHCO₂Et and I. The catalysts were characterized by various techniques, including XRD, BET, SEM, TEM, XPS, NH₃-TPD and in situ FTIR. The characterization results indicated that TiO₂ catalysts with exposed (110) and (101) facets were synthesized successfully. The overall results suggested that the (101) facets on the TiO₂ surface provide high amounts of surface Lewis acid sites that played a pivotal role in PDC formation, which gave a conversion and yield both up to 99% under optimized conditions. In situ FTIR spectroscopy clearly revealed that polyurea as an intermediate was formed in the reaction and subsequently converted to PDC catalyzed by the TiO₂ catalyst. Furthermore, the DFT results showed that the conversion of polyurea to PDC over the (101) facets was more prone to occur than the (110) facets due to the lower reaction energy barrier. In addition, the TiO₂-101 catalyst displayed excellent stability without an obvious activity decline after five cycles.

Catalysis Science & Technology published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Category: quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Akinbobuyi, Babatope published the artcileSynthesis and immunostimulatory activity of substituted TLR7 agonists, Application In Synthesis of 1353016-70-2, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(17), 4246-4249, database is CAplus and MEDLINE.

Fifteen new substituted 9-benzyladenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds, were analyzed for TLR7 activity and for the selective stimulation of B cell proliferation. Several functionalized derivatives exhibit significant activity, suggesting their potential for use as vaccine adjuvants.

Bioorganic & Medicinal Chemistry Letters published new progress about 1353016-70-2. 1353016-70-2 belongs to quinuclidine, auxiliary class Other Aromatic Heterocyclic,Carboxylic acid,Amide,Inhibitor,Inhibitor, name is Dbco-acid, and the molecular formula is C19H15NO3, Application In Synthesis of 1353016-70-2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider