Heterocyclic Building Blocks-Quinuclidine

Guo, Xiangyu published the artcileRuthenium-Catalyzed Para-Selective Oxidative Cross-Coupling of Arenes and Cycloalkanes, Application In Synthesis of 20029-52-1, the publication is Organic Letters (2011), 13(19), 4977-4979, database is CAplus and MEDLINE.

A novel, direct para-selective oxidative cross-coupling of benzene derivatives with cycloalkanes catalyzed by ruthenium was developed. A wide range of arenes bearing electron-withdrawing substituents was functionalized directly with simple cycloalkanes with high para-selectivity; arenes with electron-donating groups were mainly para-functionalized. Benzoic acid can be used directly.

Organic Letters published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Application In Synthesis of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Frigione, Mariaenrica published the artcileExperimental cold-cured nanostructured epoxy-based hybrid formulations: properties and durability performance, Synthetic Route of 1761-71-3, the publication is Polymers (Basel, Switzerland) (2020), 12(2), 476, database is CAplus and MEDLINE.

Different hybrid epoxy formulations were produced and cold-cured, monitoring the properties development during low temperature curing and aging. All systems were based on silane functionalized bisphenol A (DGEBA) resins (part A), cured at ambient temperature with two amine hardeners (part B). The different components of the formulations were selected on their potential capability to bring about enhancements in the glass transition temperature The durability of the produced hybrids was probed in comparison to the corresponding neat epoxies by monitoring changes in glass transition temperature (T_g) and flexural mech. properties after exposure to different levels of humidity and immersion in water and at temperatures slightly higher than the local ambient temperature, in order to simulate the conditions encountered during summer seasons in very humid environments. The thermal degradation resistance of the hybrid systems was also evaluated by thermogravimetric anal.

Polymers (Basel, Switzerland) published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Synthetic Route of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Cho, Sung Min published the artcileA Guanidine-Based Synthetic Compound Suppresses Angiogenesis via Inhibition of Acid Ceramidase, Related Products of quinuclidine, the publication is ACS Chemical Biology (2019), 14(1), 11-19, database is CAplus and MEDLINE.

Angiogenesis generates new blood vessels from pre-existing vessels. Tumors induce the formation of new blood vessels to ensure sufficient oxygen and nutrients for their growth. Normally, angiogenesis is induced by various pro-angiogenesis factors, including vascular endothelial growth factor (VEGF). Inhibition of VEGF is a promising approach to cancer treatment. A guanidine-based synthetic compound, E2, was identified as a potent hit from 68 guanidine-based derivatives by screening for angiogenesis inhibitors showing antiproliferative activity in human umbilical vein endothelial cells (HUVECs). To explore the mode of action of E2(I), target proteins were investigated using phage display biopanning, and acid ceramidase 1 (ASAH1) was identified as an E2-binding protein. Drug affinity responsive target stability (DARTS) and ASAH1 activity assays revealed the direct binding of E2 to ASAH1. Moreover, siRNA knockdown of ASAH1 demonstrated its role as an angiogenesis factor. Consequently, E2 inhibited chemoinvasion and tube formation of HUVECs in a dose-dependent manner. E2 also potently suppressed neo-vascularization of chorioallantoic membranes in vivo. Collectively, these data suggest that E2 is a novel angiogenesis inhibitor and ASAH1 is proposed to be a new antiangiogenesis target.

ACS Chemical Biology published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Yun’kova, T. A. published the artcileLiquid-phase catalytic oxidation of cyclohexyl and phenyl toluene derivatives, HPLC of Formula: 20029-52-1, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (2008), 51(4), 36-37, database is CAplus.

Liquid-phase catalytic oxidation of cyclohexyltoluene (I) and methylbiphenyl isomer mixtures in acetic acid in the presence of the cobalt acetate with formation of the p-cyclohexylbenzoic acid has been studied. It has been found that oxidation I in acetic acid at 95 – 100° during 6 h in the presence 0.1 mol cobalt acetate and 0.1 mol isobutyraldehyde as an initiator gave p-cyclohexylbenzoic acid with yield 92%.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C15H14N2, HPLC of Formula: 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Armstrong, Megan K. published the artcileDifferential Dihydrofunctionalization of Terminal Alkynes: Synthesis of Benzylic Alkyl Boronates through Reductive Three-Component Coupling, Related Products of quinuclidine, the publication is Journal of the American Chemical Society (2019), 141(15), 6173-6179, database is CAplus and MEDLINE.

The differential dihydrofunctionalization of terminal alkynes is accomplished through the reductive three-component coupling of terminal alkynes, aryl halides, and pinacolborane. The transformation results in hydrofunctionalization of both π-bonds of an alkyne in a single reaction promoted by cooperative action of a Cu/Pd catalyst system. The differential dihydrofunctionalization reaction has excellent substrate scope and can be accomplished in the presence of esters, nitriles, alkyl halides, epoxides, acetals, alkenes, aryl halides, and silyl ethers. Mechanistic experiments indicate that the reaction proceeds through Cu-catalyzed hydroboration followed by a 2nd hydrocupration. The resulting heterobimetallic complex is the key intermediate that participates in the subsequent Pd-catalyzed cross-coupling, which furnishes benzylic alkyl boronate products.

Journal of the American Chemical Society published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Santos, Sadella C. published the artcileEffect of microcapsule content on Diels-Alder room temperature self-healing thermosets, Computed Properties of 1761-71-3, the publication is Polymers (Basel, Switzerland) (2020), 12(12), 3064, database is CAplus and MEDLINE.

A furan functionalized epoxy-amine thermoset with an embedded microcapsule healing system that utilizes reversible Diels-Alder healing chem. was used to investigate the influence of microcapsule loading on healing efficiency. A urea-formaldehyde encapsulation technique was used to create capsules with an average diameter of 150μm that were filled with a reactive solution of bismaleimide in Ph acetate. It was found that optimum healing of the thermoset occurred at 10 weight% microcapsule content for the compositions investigated. The diffusion of solvent through the crack interface and within fractured samples was investigated using anal. diffusion models. The decrease in healing efficiency at higher microcapsule loading was attributed partially to solvent-induced plasticization at the interface. The diffusion anal. also showed that the 10% optimum microcapsule concentration occurs for systems with the same interfacial solvent concentration This suggests that addnl. phys. and chem. phenomena are also responsible for the observed optimum. Such phenomena could include a reduction in surface area available for healing and the saturation of interfacial furan moieties by reaction with increasing amounts of maleimide. Both would result from increased microcapsule loading.

Polymers (Basel, Switzerland) published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Computed Properties of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Hu, Fengshuo published the artcileEpoxidized soybean oil modified using fatty acids as tougheners for thermosetting epoxy resins: Part 2-Effect of curing agent and epoxy molecular weight, Safety of 4,4-Diaminodicyclohexyl methane, the publication is Journal of Applied Polymer Science (2021), 138(24), 50579, database is CAplus.

A series of bio-rubber (BR) tougheners for thermosetting epoxy resins was prepared by grafting renewable fatty acids with different chain lengths onto epoxidized soybean oil at varying molar ratios. BR-toughened samples were prepared by blending BRs with diglycidyl ether of bisphenol A resins, Epon 828 and Epon 1001F, at different weight fractions and stoichiometrically cured using an amine curing agent, 4, 4′-methylene biscyclohexanamine (PACM). Fracture toughness properties of the unmodified and BR toughened polymer samples-including critical strain energy release rate (G_Ic), and critical stress intensity factor (K_Ic)-were measured to investigate the toughening effect of prepared BRs. It was found that the degree of phase separation and toughening were more controllable relative to similar polymers cured using the aromatic curing agent Epikure W, and the use of higher mol. epoxy resins produces a synergistic effect increasing the toughness much more than similar polymers made with lower mol. weight epoxy resins. Average BR domain sizes ranging from 200 to 900 nm were observed, and formulations with G_Ic, values K_Ic as high as 1.0 kJ/m² and 1.4 MPa m^1/2 were attained resp. for epoxy systems with T_g greater than 130°C.

Journal of Applied Polymer Science published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Safety of 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Rumyantseva, Yu. B. published the artcileIntensification of oxidation of cyclohexyltoluene to hydroperoxide, Computed Properties of 20029-52-1, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (2011), 54(10), 102-104, database is CAplus.

Liquid phase oxidation of cyclohexyltoluene to hydroperoxide was studied in the presence of initiator – isopropylbenzene hydroperoxide and nitrogen-containing catalysts. The oxidation rate of cyclohexyltoluene increases 2.5-3 times at the presence of N-hydroxyphthalimide at 110-140°. The hydrocarbon conversion is up to 28-30% and the selectivity of cyclohexyltoluene hydroperoxide I formation is 93-95%.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Computed Properties of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Sekhar, B. V. V. N. Chandra published the artcileSynthesis of Montelukast sodium via an ester intermediate; synthesis and characterization of impurities, HPLC of Formula: 162515-68-6, the publication is International Journal of Pharma and Bio Sciences (2011), 2(3), 399-407, database is CAplus.

Novel synthetic approaches for the synthesis of a leukotriene receptor antagonist, Montelukast sodium [i.e., 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt] were designed. Reduction of the starting material [methyl (E)-2-[3-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoate] provided an alc. compound and the formation of montelukast dicyclohexylamine was accomplished by subsequent introduction of (mercaptomethyl)cyclopropaneacetic acid. The current study also deals with the synthesis and characterization of reaction products which are classified as impurities of Montelukast sodium. Impurities and byproducts reported here included a sulfine (sulfoxide), (S)-montelukast (acid), etc.

International Journal of Pharma and Bio Sciences published new progress about 162515-68-6. 162515-68-6 belongs to quinuclidine, auxiliary class Thiol,Carboxylic acid,Aliphatic cyclic hydrocarbon, name is 2-(1-(Mercaptomethyl)cyclopropyl)acetic acid, and the molecular formula is C10H16Br3N, HPLC of Formula: 162515-68-6.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Fredenhagen, Andreas published the artcileEvaluation of the optimization space for atmospheric pressure photoionization (APPI) in comparison with APCI, COA of Formula: C13H16O2, the publication is Journal of Mass Spectrometry (2014), 49(8), 727-736, database is CAplus and MEDLINE.

The usefulness of atm. pressure photoionization (APPI) is difficult to evaluate for unknowns due to the fragmented literature. Specifically, the variation of dopants with a wide set of compounds or the use of APPI in the neg. mode have rarely been explored. Thirty compounds were selected that were not suitable for ESI with a wide variety of functional groups and investigated with atm. pressure chem. ionization (APCI) and APPI in the pos. and neg. ion modes. The influence of the mobile phase (eluents containing acetonitrile or methanol) and – for APPI – four different dopants (acetone, chlorobenzene, toluene, and toluene/anisole) were explored. Stepwise variation of the organic mobile phase allowed to elucidate the ionization mechanism. Atm. pressure photoionization was especially useful for compounds, where the M^•+ and not the [M + H]⁺ was formed. The dopants chlorobenzene and anisole promoted the formation of mol. ions M^•+ for about half of the compounds, and its formation was also pos. influenced by the use of mobile phases containing methanol. In the neg. ion mode, APPI offered no advantage toward APCI. Best results were generally achieved with the dopant chlorobenzene, establishing that this dopant is suitable for a wide set of compounds For one quarter of the compounds, significantly better results were achieved with mobile phases containing methanol for both APPI and APCI than those with acetonitrile, but only in the pos. mode. With either of the methods – APPI or APCI – about 10% of the compounds were not detected. Strategies to get results quickly with difficult unknowns will be discussed.

Journal of Mass Spectrometry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, COA of Formula: C13H16O2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider