Heterocyclic Building Blocks-Quinuclidine

Song, Sam Cha published the artcileSynthesis and properties of waterborne polyurethane dispersions for surface coatings on poly(vinyl chloride), Formula: C13H26N2, the publication is Molecular Crystals and Liquid Crystals (2020), 706(1), 101-107, database is CAplus.

Recently, conventional solvent-typed polyurethanes are subject to many regulations due to emission of organic volatile compounds (VOCs) and researches have been focused on eco-friendly waterborne polyurethane dispersions (WPUDs) as an alternative of conventional solvent-typed ones causing poor working environment. PVC is widely used because of low price and good heat and fire resistance. To develop eco-friendly coatings on poly(vinyl chloride) (PVC), various WPUDs were synthesized by combination of polyol such as polyester, polycaprolactone, polyether or polycarbonate, hydrophilic compounds (dimethylol butanoic acid, DMBA), and reactive silicone. The structure and properties of synthesized WPUDs were characterized by FT-IR, particle size, contact angle, surface energy, tensile strength, elongation, and adhesion strength. Also, their particle sizes decreased while tensile strengths increased with increasing DMBA content. Surface energy and contact angle of WPUDs were strongly affected by the content of hydrophobic reactive silicone. The optimum properties of WPUDs were obtained by controlling their compositions, polyol, hydrophilic compound, and reactive silicone.

Molecular Crystals and Liquid Crystals published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C6H13BO3, Formula: C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Chen, Fengbiao published the artcileThe effect of latent plasticity on the shape recovery of a shape memory vitrimer, Name: 4,4-Diaminodicyclohexyl methane, the publication is European Polymer Journal (2021), 110304, database is CAplus.

The utility of covalent crosslinkers as permanent netpoints has enabled robust shape memory behavior in shape memory thermosets (SMTs). Having this permanent crosslinked structure, alternatively, challenges the reprogramming of permanent shapes. The introduction of vitrimeric type dynamic chem. into SMTs allows for reconfiguration of crosslinked network and thus reprogramming of permanent shapes. However, adding this adaptability/plasticity to the network could potentially affect the shape memory behavior, especially when the shape programming is conducted at a temperature that activates the network plasticity as well. Herein, to address the potential influence of network plasticity, we studied the shape memory behavior of a shape memory vitrimer (SMV) that possesses a low network activation energy (Ea) of 33 kJ/mol, which indicates a relatively high plasticity index during shape programming. As we found, there is a dependence of shape recovery on the shape-programming time: a longer programming time leads to a poorer shape recovery. This neg. correlation results from the dissipation of stored elastic energy at local strained regions associated with shape programming. We further related the loss of elastic energy to the stress-relaxation that results from chain exchanges. Accordingly, the dependence can be analyzed with an analog of stress-relaxation model.

European Polymer Journal published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Name: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Liu, Zheng-Fei published the artcileUltralong lifetime room temperature phosphorescence and dual-band waveguide behavior of phosphoramidic acid oligomers, Computed Properties of 1761-71-3, the publication is Journal of Materials Chemistry C: Materials for Optical and Electronic Devices (2020), 8(22), 7330-7335, database is CAplus.

Phosphoramidic acid is introduced into an oligomer matrix to construct a nonconjugated luminescence system with ultralong phosphorescence lifetimes up to 376.5 and 776.9 ms and high phosphorescence quantum yield (4.6-10.5%). At the same time, the new system also displays good thermo-processing properties, vitreous solid and optical waveguide behavior.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Computed Properties of 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Li, Zhen published the artcileDiscovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (S1P₁) Receptor Agonists with Exceptional Selectivity against S1P₂ and S1P₃, Related Products of quinuclidine, the publication is Journal of Medicinal Chemistry (2005), 48(20), 6169-6173, database is CAplus and MEDLINE.

A class of 3,5-diphenyl-1,2,4-oxadiazole based compounds have been identified as potent sphingosine-1-phosphate-1 (S1P₁) receptor agonists with minimal affinity for the S1P₂ and S1P₃ receptor subtypes. Analog 26 (S1P₁ IC₅₀ = 0.6 nM) has an excellent pharmacokinetics profile in the rat and dog and is efficacious in a rat skin transplant model, indicating that S1P₃ receptor agonism is not a component of immunosuppressive efficacy.

Journal of Medicinal Chemistry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Related Products of quinuclidine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Yi, Pengcheng published the artcileSelf-Healable, Strong, and Tough Polyurethane Elastomer Enabled by Carbamate-Containing Chain Extenders Derived from Ethyl Carbonate, HPLC of Formula: 1761-71-3, the publication is Polymers (Basel, Switzerland) (2022), 14(9), 1673, database is CAplus and MEDLINE.

Com. diol chain extenders generally could only form two urethane bonds, while abundant hydrogen bonds were required to construct self-healing thermoplastic polyurethane elastomers (TPU). Herein, two diol chain extenders bis(2-hydroxyethyl) (1,3-pheny-lene-bis-(methylene)) dicarbamate (BDM) and bis(2-hydroxyethyl) (methylenebis(cyclohexane-4,1-diy-l)) dicarbamate (BDH), containing two carbamate groups were successfully synthesized through the ring-opening reaction of ethylene carbonate (EC) with 1,3-benzenedimetha-namine (MX-DA) and 4, 4′-diaminodicyclohexylmethane (HMDA). The two chain extenders were applied to successfully achieve both high strength and high self-healing ability. The BDM-1.7 and BDH-1.7 elastomers had high comprehensive self-healing efficiency (100%, 95%) after heated treatment at 60 °C, and exhibited exceptional comprehensive mech. performances in tensile strength (20.6 ± 1.3 MPa, 37.1 ± 1.7 MPa), toughness (83.5 ± 2.0 MJ/m³, 118.8 ± 5.1 MJ/m³), puncture resistance (196.0 mJ, 626.0 mJ), and adhesion (4.6 MPa, 4.8 MPa). The peculiar mech. and self-healing properties of TPUs originated from the coexisting short and long hard segments, strain-induced crystallization (SIC). The two elastomers with excellent properties could be applied to engineering-grade fields such as com. sealants, adhesives, and so on.

Polymers (Basel, Switzerland) published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C3H7NO2, HPLC of Formula: 1761-71-3.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Liu, Yingchun published the artcileUltrahigh thermal conductivity of epoxy composites based on curling bioinspired functionalized graphite films for thermal management application, Formula: C13H26N2, the publication is Composites, Part A: Applied Science and Manufacturing (2021), 106413, database is CAplus.

Unsatisfactory thermal conductive network (TCN) and poor heat conduction interface have limited thermal conductivity (TC) enhancement in the polymeric composites. In this study, inspired by mussels and a Chinese delicacy called the Hanamaki, a facile and environmental strategy is developed to prepare hierarchically ordered graphite film strips@polydopamine/epoxy (GFs@PDA/EP) composites. Organized TCNs and an optimized interface were constructed and thus an ultrahigh TC of GFs/EP (899.44 ± 18.51 W m^-1 K^-1) in perpendicular direction was obtained. Structural anal. and heat-transfer passages model suggests that superior TCNs were constructed and the designed structure is conducive for heat conduction in the perpendicular direction. Moreover, the interfacial bonding of GFs@PDA with EP matrix contributes to the remarkable enhancement of TC with increasing of PDA coverage. A decrease of ∼43°C in the thermal management experiment of LED chips indicated that it most likely becomes a good candidate in electronic device-cooling application.

Composites, Part A: Applied Science and Manufacturing published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Formula: C13H26N2.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

O’Donnell, Michael published the artcile2-Chloro-4-tetrafluorophenoxypyrimidine: a versatile reagent for C-2 prior to C-4 functionalizations, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, the publication is Tetrahedron Letters (2016), 57(17), 1882-1884, database is CAplus.

A novel synthetic route to 2,4-functionalized pyrimidines is reported. The approach uses 2-chloro-4-tetrafluorophenoxypyrimidine, that enables sequential palladium catalyzed functionalization at the pyrimidine C-2 position, followed by S_NAr displacement with diverse amines at C-4. The broad utility of this “C-2 then C-4” functionalization sequence has been demonstrated with a range of cross-coupling partners and amines.

Tetrahedron Letters published new progress about 1160556-64-8. 1160556-64-8 belongs to quinuclidine, auxiliary class Mono-phosphine Ligands, name is 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine, and the molecular formula is C28H41N2P, Recommanded Product: 2′-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethyl-[1,1′-biphenyl]-2,6-diamine.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Ou, Shuo-jun published the artcileDetermination of seven kinds of alkylamines in food contact plastic materials by amidation coupled with high performance liquid chromatography-quadrupole time-of-flight mass spectrometer, Name: 4,4-Diaminodicyclohexyl methane, the publication is Fenxi Huaxue (2020), 48(3), 413-422, database is CAplus.

A high performance liquid chromatog.-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) method for determination of seven kinds of alkylamines was established. Samples were amidated with 0.4% benzyl chloroformate (Cbz-Cl) in acetonitrile-sodium carbonate solution (50:50, V/V). The amidated conditions, including concentration of sodium carbonate solution (1.5%, m/V), benzyl chloroformate ratio and amount of sodium chloride (1.5 g), were optimized by response surface methodol. Under the optimized chromatog. and mass spectrometer conditions, the data were collected with electrospray ionization (ESI) sources under pos. ion mode. The calibration curves of seven kinds of alkylamines showed good linearity in concentration range of 1.0-500μg/L(R² > 0.9957). The average recoveries were 82.0-108.0%, the limits of detection and quantification were 0.5-1.0μg/kg and 2.0-4.0μg/kg, resp., and the relative standard deviations (RSDs) were 3.5-6.8%. This method is efficient and easy to be operated, and has good sensitivity, high precision and accuracy in the determination of seven alkylamines in food contact plastic materials.

Fenxi Huaxue published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C13H26N2, Name: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Lukesh, John C. published the artcileVinblastine 20′ Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance, Application In Synthesis of 20029-52-1, the publication is Journal of Medicinal Chemistry (2017), 60(17), 7591-7604, database is CAplus and MEDLINE.

A series of 180 vinblastine 20′ amides were prepared in three steps from com. available starting materials, systematically exploring a typically inaccessible site in the mol. enlisting a powerful functionalization strategy. Clear structure-activity relationships and a structural model were developed in the studies which provided many such 20′ amides that exhibit substantial and some even remarkable enhancements in potency, many that exhibit further improvements in activity against a Pgp overexpressing resistant cancer cell line, and an important subset of the vinblastine analogs that display little or no differential in activity against a matched pair of vinblastine sensitive and resistant (Pgp overexpressing) cell lines. The improvements in potency directly correlated with target tubulin binding affinity, and the reduction in differential functional activity against the sensitive and Pgp overexpressing resistant cell lines was found to correlate directly with an impact on Pgp-derived efflux.

Journal of Medicinal Chemistry published new progress about 20029-52-1. 20029-52-1 belongs to quinuclidine, auxiliary class Carboxylic acid,Benzene, name is 4-Cyclohexylbenzoic acid, and the molecular formula is C13H16O2, Application In Synthesis of 20029-52-1.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider

Zuo, Hanqi published the artcileEffect of structure on the properties of ambient-cured coating films prepared via a Michael addition reaction based on an acetoacetate-modified castor oil prepared by thiol-ene coupling, Recommanded Product: 4,4-Diaminodicyclohexyl methane, the publication is Progress in Organic Coatings (2019), 27-33, database is CAplus.

The Michael addition reaction was used to create ambient curable film materials based on an acetoacetate-modified castor oil, and a multifunctional alamine was prepared The thiol-ene coupling reaction could change the proportion of hydroxyl groups in the castor oil, thereby improving the crosslinking d. and mech. properties of the coating films. The acetoacetate-modified castor oil was achieved in two steps. First, the C=C bonds of castor oil were coupled using a thiol-ene coupling reaction, which has a high conversion rate and few byproducts. Second, acetoacetate-modified castor oil was prepared by a transesterification reaction between tert-Bu acetoacetate and modified castor oil. The acetoacetate-modified castor oil was characterized by NMR (NMR), Fourier transform IR spectroscopy (FTIR), gel permeation chromatog. (GPC) and viscosity measurements. Finally, coating films were prepared from the acetoacetate-modified castor oil and 4,4-diaminecyclohexylmethane via a Michael addition reaction at room temperature (25 °C). The mech. properties were noticeably improved compared to those of the unmodified castor oil film. The tensile properties increased from 0.68 MPa to 1.76 MPa, and the glass transition temperature (T_g) increased by approx. 30 °C.

Progress in Organic Coatings published new progress about 1761-71-3. 1761-71-3 belongs to quinuclidine, auxiliary class Ploymers, name is 4,4-Diaminodicyclohexyl methane, and the molecular formula is C10H9NO4S, Recommanded Product: 4,4-Diaminodicyclohexyl methane.

Referemce:
https://en.wikipedia.org/wiki/Quinuclidine,
Quinuclidine | C7H13N | ChemSpider